Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Delaney K. Sullivan"'
Autor:
Anja Deutzmann, Delaney K. Sullivan, Renumathy Dhanasekaran, Wei Li, Xinyu Chen, Ling Tong, Wadie D. Mahauad-Fernandez, John Bell, Adriane Mosley, Angela N. Koehler, Yulin Li, Dean W. Felsher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively identify genes essential for survival of MYC high but not MYC low cells by a CR
Externí odkaz:
https://doaj.org/article/5d5960aaff2349adbf61a3465136928e
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Chemotherapy resistance poses a major obstacle in cancer therapy. Here, the authors identify the mTOR pathway as a determinant of chemosensitivity and demonstrate that inhibition of mTOR promotes the persistence of a chemotherapy-resistant cancer-cel
Externí odkaz:
https://doaj.org/article/48df2d8aba604f5392daade1ac614d9d
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal cancers, is driven by oncogenic KRAS mutations. Farnesyl thiosalicylic acid (FTS), also known as salirasib, is a RAS inhibitor that selectively dislodges active RAS p
Externí odkaz:
https://doaj.org/article/6e4cb1857d5a4b5b94e7d6deb5c10700
Autor:
Delaney K. Sullivan, Anja Deutzmann, Josiah Yarbrough, Maya S. Krishnan, Arvin M. Gouw, David I. Bellovin, Stacey J. Adam, Daniel F. Liefwalker, Renumathy Dhanasekaran, Dean W. Felsher
Publikováno v:
Oncogene. 41:4960-4970
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3eb64b45b6309a74b1576bf01221b33
https://doi.org/10.1038/s41388-022-02458-9
https://doi.org/10.1038/s41388-022-02458-9
Autor:
Delaney K. Sullivan, Lior Pachter
Publikováno v:
bioRxiv
Next-generation sequencing libraries are constructed with numerous synthetic constructs such as sequencing adapters, barcodes, and unique molecular identifiers. Such sequences can be essential for interpreting results of sequencing assays, and when t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbeb6b72ce5255b9fd85bcd3318882f
https://doi.org/10.1101/2023.03.20.533521
https://doi.org/10.1101/2023.03.20.533521
Autor:
Benjamin A. H. Smith, Anja Deutzmann, Kristina M. Correa, Corleone S. Delaveris, Renumathy Dhanasekaran, Christopher G. Dove, Delaney K. Sullivan, Simon Wisnovsky, Jessica C. Stark, John V. Pluvinage, Srividya Swaminathan, Nicholas M. Riley, Anand Rajan, Ravindra Majeti, Dean W. Felsher, Carolyn R. Bertozzi
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The Siglecs (sialic acid-binding immunoglobulin-like lectins) are glycoimmune checkpoint receptors that suppress immune cell activation upon engagement of cognate sialoglycan ligands. The cellular drivers underlying Siglec ligand production on cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2694bbb5db98e831f8954611f3dc713
https://doi.org/10.1073/pnas.2215376120
https://doi.org/10.1073/pnas.2215376120
Autor:
Kristján Eldjárn Hjörleifsson, Delaney K. Sullivan, Guillaume Holley, Páll Melsted, Lior Pachter
The presence of both nascent and mature mRNA molecules in single-cell RNA-seq data leads to ambiguity in the notion of a “count matrix”. Underlying this ambiguity, is the challenging problem of separately quantifying nascent and mature mRNAs. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a667ee436eee3a6a06a63bff972918ff
https://doi.org/10.1101/2022.12.02.518832
https://doi.org/10.1101/2022.12.02.518832
Chemotherapy can eradicate a majority of cancer cells. However, a small population of tumor cells often survives drug treatments through genetic and/or non-genetic mechanisms, leading to tumor recurrence. Here we report a reversible chemoresistance p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13fd7511bbd564aaf03738e2ae5bd5b5
https://doi.org/10.1101/2022.01.19.476916
https://doi.org/10.1101/2022.01.19.476916
Autor:
Delaney K, Sullivan, Anja, Deutzmann, Josiah, Yarbrough, Maya S, Krishnan, Arvin M, Gouw, David I, Bellovin, Stacey J, Adam, Daniel F, Liefwalker, Renumathy, Dhanasekaran, Dean W, Felsher
Publikováno v:
Oncogene. 41(45)
MYC is a transcription factor frequently overexpressed in cancer. To determine how MYC drives the neoplastic phenotype, we performed transcriptomic analysis using a panel of MYC-driven autochthonous transgenic mouse models. We found that MYC elicited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03c37dfedb08a373b20abd5bb39a508b
https://pubmed.ncbi.nlm.nih.gov/36207533
https://pubmed.ncbi.nlm.nih.gov/36207533
Autor:
Susan T. Weintraub, Junjie Chen, Dana Molleur, Delaney K. Sullivan, Sammy Pardo, Nancy G. Azizian, Litong Nie, Yulin Li
Publikováno v:
J Proteome Res
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers. Dissecting the tumor cell proteome from that of the non-tumor cells in the PDAC tumor bulk is critical for tumorigenesis studies, biomarker discovery, and development of therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2910b0fb202ed157ad542decedc487
https://pubmed.ncbi.nlm.nih.gov/33289385
https://pubmed.ncbi.nlm.nih.gov/33289385