Zobrazeno 1 - 10
of 1 031
pro vyhledávání: '"Delaney K"'
Autor:
Anja Deutzmann, Delaney K. Sullivan, Renumathy Dhanasekaran, Wei Li, Xinyu Chen, Ling Tong, Wadie D. Mahauad-Fernandez, John Bell, Adriane Mosley, Angela N. Koehler, Yulin Li, Dean W. Felsher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively identify genes essential for survival of MYC high but not MYC low cells by a CR
Externí odkaz:
https://doaj.org/article/5d5960aaff2349adbf61a3465136928e
Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum
Autor:
Marco D. Carpenter, Delaney K. Fischer, Shuo Zhang, Allison M. Bond, Kyle S. Czarnecki, Morgan T. Woolf, Hongjun Song, Elizabeth A. Heller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Bulk or pooled epigenomic profiling in the heterogenous brain obscures cell-type-specificity and individual subject variability in gene regulation. Here the authors optimized a hybrid protocol, ICuRuS, to profile epigenetic features in neuronal subty
Externí odkaz:
https://doaj.org/article/4bcaf0d56695409fa418a111b3df48ee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Chemotherapy resistance poses a major obstacle in cancer therapy. Here, the authors identify the mTOR pathway as a determinant of chemosensitivity and demonstrate that inhibition of mTOR promotes the persistence of a chemotherapy-resistant cancer-cel
Externí odkaz:
https://doaj.org/article/48df2d8aba604f5392daade1ac614d9d
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Cocaine epigenetically regulates gene expression via changes in histone post-translational modifications (HPTMs). We previously found that the immediate early gene Nr4a1 is epigenetically activated by cocaine in mouse brain reward regions. H
Externí odkaz:
https://doaj.org/article/713ecbeb668144dab935340d56106536
Autor:
Delaney K. Geitgey, Anja J. Melendez, Raquel Caldeira‐Botelho, Melissa L. Kemp, Curtis J. Henry
Publikováno v:
ImmunoMedicine, Vol 3, Iss 1-2, Pp n/a-n/a (2023)
Abstract In addition to its universally known role in transferring genetic material, DNA nucleotides and nucleosides are regarded as the most ancient form of extracellular signaling molecules. This unique signaling pathway was first reported by Dr. A
Externí odkaz:
https://doaj.org/article/08625c5236e04bedb2d59a0194a5d50a
Autor:
Miyoung Lee, Delaney K. Geitgey, Jamie A. G. Hamilton, Jeremy M. Boss, Christopher D. Scharer, Jennifer M. Spangle, Karmella A. Haynes, Curtis J. Henry
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The world’s population with obesity is reaching pandemic levels. If current trends continue, it is predicted that there will be 1.5 billion people with obesity by 2030. This projection is alarming due to the association of obesity with numerous dis
Externí odkaz:
https://doaj.org/article/256b4796d3674787b290beebc2961457
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal cancers, is driven by oncogenic KRAS mutations. Farnesyl thiosalicylic acid (FTS), also known as salirasib, is a RAS inhibitor that selectively dislodges active RAS p
Externí odkaz:
https://doaj.org/article/6e4cb1857d5a4b5b94e7d6deb5c10700
Autor:
Marco D. Carpenter, Delaney K. Fischer, Shuo Zhang, Allison M. Bond, Kyle S. Czarnecki, Morgan T. Woolf, Hongjun Song, Elizabeth A. Heller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/94a49a491e4d4ee98eb917a96088132f
Publikováno v:
Neurobiology of Stress, Vol 7, Iss , Pp 27-37 (2017)
Chronic stress is known to precipitate and exacerbate neuropsychiatric symptoms, and exposure to stress is particularly pathological in individuals with certain genetic predispositions. Recent genome wide association studies have identified single nu
Externí odkaz:
https://doaj.org/article/d7276c54d8694ad99e68cac826ec6894
Autor:
Bacon, S.L., Lavoie, K.L., Gautier, A., Marion, P., Alberga, A., Denis, R., Garneau, P., Lavigne, G., Pescarus, R., Raymond-Carrier, S., Santosa, S., Studer, A.S., Ben-Porat, T., Delaney, K., Fortin, A., Julien, C., Mercier, L., Woods, R., Yousef, R., Yousefi, Reyhaneh, Ben-Porat, Tair, Marques Vieira, Ariany, Lavoie, Kim L., Bacon, Simon L.
Publikováno v:
In Surgery for Obesity and Related Diseases August 2024