Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types

Autor: Ecker, Simone, Chen, Lu, Pancaldi, Vera, Bagger, Frederik O., Fernández, José María, Carrillo de Santa Pau, Enrique, Juan, David, Mann, Alice L., Watt, Stephen, Casale, Francesco Paolo, Sidiropoulos, Nikos, Rapin, Nicolas Philippe Jean-Pierre, Merkel, Angelika, Stunnenberg, Hendrik G, Stegle, Oliver, Frontini, Mattia, Downes, Kate, Pastinen, Tomi, Kuijpers, Taco W, Rico, Daniel, Valencia, Alfonso, Beck, Stephan, Soranzo, Nicole, Paul, Dirk S., Albers, Cornelis A., Amstislavskiy, Vyacheslav, Ashford, Sofie, Bomba, Lorenzo, Bujold, David, Burden, Frances, Busche, Stephan, Caron, Maxime, Chen, Shu-Huang, Cheung, Warren A., Clarke, Laura, Colgiu, Irina, Datta, Avik, Delaneau, Oliver, Elding, Heather, Farrow, Samantha, Garrido-Martín, Diego, Ge, Bing, Guigo, Roderic, Iotchkova, Valentina, Kundu, Kousik, Kwan, Tony, Lambourne, John J., Lowy, Ernesto, Mead, Daniel, Pourfarzad, Farzin, Redensek, Adriana, Rehnstrom, Karola, Rendon, Augusto, Richardson, David M., Risch, Thomas, Rowlston, Sophia, Shao, Xiaojian, Simon, Marie Michelle, Sultan, Marc, Walter, Klaudia, Wilder, Steven P., Yan, Ying, Antonarakis, Stylianos E., Bourque, Guillaume, Dermitzakis, Emmanouil T., Flicek, Paul, Lehrach, Hans, Martens, Joost H A, Yaspo, Marie-Laure, Ouwehand, Willem H.

Publikováno v: Ecker, S, Chen, L, Pancaldi, V, Bagger, F O, Fernández, J M, Carrillo de Santa Pau, E, Juan, D, Mann, A L, Watt, S, Casale, F P, Sidiropoulos, N, Rapin, N P J-P, Merkel, A, Stunnenberg, H G, Stegle, O, Frontini, M, Downes, K, Pastinen, T, Kuijpers, T W, Rico, D, Valencia, A, Beck, S, Soranzo, N, Paul, D S, Albers, C A, Amstislavskiy, V, Ashford, S, Bomba, L, Bujold, D, Burden, F, Busche, S, Caron, M, Chen, S-H, Cheung, W A, Clarke, L, Colgiu, I, Datta, A, Delaneau, O, Elding, H, Farrow, S, Garrido-Martín, D, Ge, B, Guigo, R, Iotchkova, V, Kundu, K, Kwan, T, Lambourne, J J, Lowy, E, Mead, D, Pourfarzad, F, Redensek, A, Rehnstrom, K, Rendon, A, Richardson, D M, Risch, T, Rowlston, S, Shao, X, Simon, M M, Sultan, M, Walter, K, Wilder, S P, Yan, Y, Antonarakis, S E, Bourque, G, Dermitzakis, E T, Flicek, P, Lehrach, H, Martens, J H A, Yaspo, M-L & Ouwehand, W H 2017, ' Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types ', Genome Biology, vol. 18, no. 1, 18 . https://doi.org/10.1186/s13059-017-1156-8

Background: A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. Results: We apply a novel analytical approach to measu

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https://curis.ku.dk/ws/files/181453200/Ecker_2017_Genome_wide_analysis.pdf