Altered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy.

Autor: Gömöri K; Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, 44801 Bochum, Germany.; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; HCEMM-Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, University of Budapest, HU-1089 Budapest, Hungary., Herwig M; Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, 44801 Bochum, Germany.; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Hassoun R; Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, 44801 Bochum, Germany.; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Budde H; Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, 44801 Bochum, Germany.; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Mostafi N; Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, 44801 Bochum, Germany.; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Delalat S; Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, 44801 Bochum, Germany.; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Modi S; Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, 44801 Bochum, Germany.; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Begovic M; Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, 44801 Bochum, Germany.; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Szabados T; Department of Pharmacology and Pharmacotherapy, University of Szeged, HU-6720 Szeged, Hungary.; Pharmahungary Group, HU-6720 Szeged, Hungary., Pipis J; Department of Pharmacology and Pharmacotherapy, University of Szeged, HU-6720 Szeged, Hungary.; Pharmahungary Group, HU-6720 Szeged, Hungary., Farkas-Morvay N; Department of Pharmacology and Pharmacotherapy, University of Szeged, HU-6720 Szeged, Hungary., Leprán I; Department of Pharmacology and Pharmacotherapy, University of Szeged, HU-6720 Szeged, Hungary., Kovács Á; Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, 44801 Bochum, Germany.; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Mügge A; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Ferdinandy P; Pharmahungary Group, HU-6720 Szeged, Hungary.; Cardiovascular and Metabolic Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, HU-1089 Budapest, Hungary., Görbe A; Department of Pharmacology and Pharmacotherapy, University of Szeged, HU-6720 Szeged, Hungary.; Pharmahungary Group, HU-6720 Szeged, Hungary.; Cardiovascular and Metabolic Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, HU-1089 Budapest, Hungary., Bencsik P; Department of Pharmacology and Pharmacotherapy, University of Szeged, HU-6720 Szeged, Hungary.; Pharmahungary Group, HU-6720 Szeged, Hungary., Hamdani N; Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, 44801 Bochum, Germany.; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; HCEMM-Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, University of Budapest, HU-1089 Budapest, Hungary.; Cardiovascular and Metabolic Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, HU-1089 Budapest, Hungary.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2022 Nov 08; Vol. 11 (11). Date of Electronic Publication: 2022 Nov 08.

Stress activated signalling impaired protein quality control pathways in human hypertrophic cardiomyopathy.

Autor: Hassoun R; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Roua.Hassoun@ruhr-uni-bochum.de., Budde H; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Heidi.Budde@ruhr-uni-bochum.de., Zhazykbayeva S; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Saltanat.Zhazykbayeva@ruhr-uni-bochum.de., Herwig M; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: melissa.herwig@rub.de., Sieme M; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Marcel.Sieme@ruhr-uni-bochum.de., Delalat S; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Simin.Delalat@ruhr-uni-bochum.de., Mostafi N; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Nusratul.Mostafi@rub.de., Gömöri K; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: kamilla.gomori@gmail.com., Tangos M; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: melli-sw@web.de., Jarkas M; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: muhammadjarkas@icloud.com., Pabel S; Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany. Electronic address: Steffen.Pabel@klinik.uni-regensburg.de., Bruckmüller S; Department of Dermatology, Skin Cancer Center, Ruhr University Bochum, Bochum, Germany. Electronic address: stefanie.bruckmueller@klinikum-bochum.de., Skrygan M; Department of Dermatology, Skin Cancer Center, Ruhr University Bochum, Bochum, Germany. Electronic address: m.skrygan@klinikum-bochum.de., Lódi M; Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Medical Faculty, Bochum, Germany. Electronic address: maria.lodi@rub.de., Jaquet K; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: kornelia.jaquet@rub.de., Sequeira V; Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Germany. Electronic address: Sequeira_V@ukw.de., Gambichler T; Department of Dermatology, Skin Cancer Center, Ruhr University Bochum, Bochum, Germany. Electronic address: thilo.gambichler@klinikum-bochum.de., Remedios CD; Molecular Biophysics, Victor Chang Cardiac Research Institute, Faculty of Medicine and Health, Darlinghurst, Australia. Electronic address: crisdos@anatomy.usyd.edu.au., Kovács Á; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: kovacs.arpad@med.unideb.hu., Mannherz HG; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Anatomy and Molecular Embryology, Ruhr University, Bochum, Germany. Electronic address: hans.g.mannherz@rub.de., Mügge A; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: Andreas.Muegge@ruhr-uni-bochum.de., Sossalla S; Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany; Clinic for Cardiology & Pneumology, Georg-August University Goettingen, and DZHK (German Centre for Cardiovascular Research), partner site Goettingen, Germany. Electronic address: samuel.sossalla@klinik.uni-regensburg.de., Hamdani N; Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany; Department of Cardiology, St. Josef-Hospital and Bergmannsheil, Ruhr University Bochum, Bochum, Germany. Electronic address: nazha.hamdani@ruhr-uni-bochum.de.

Publikováno v: International journal of cardiology [Int J Cardiol] 2021 Dec 01; Vol. 344, pp. 160-169. Date of Electronic Publication: 2021 Sep 10.

Interventricular Differences of Signaling Pathways-Mediated Regulation of Cardiomyocyte Function in Response to High Oxidative Stress in the Post-Ischemic Failing Rat Heart.

Autor: Kovács Á; Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Institut für Forschung und Lehre (IFL) Molecular and Experimental Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Herwig M; Institut für Forschung und Lehre (IFL) Molecular and Experimental Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Budde H; Institut für Forschung und Lehre (IFL) Molecular and Experimental Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Delalat S; Institut für Forschung und Lehre (IFL) Molecular and Experimental Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Kolijn D; Institut für Forschung und Lehre (IFL) Molecular and Experimental Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Bódi B; Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary., Hassoun R; Institut für Forschung und Lehre (IFL) Molecular and Experimental Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Tangos M; Institut für Forschung und Lehre (IFL) Molecular and Experimental Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Zhazykbayeva S; Institut für Forschung und Lehre (IFL) Molecular and Experimental Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Balogh Á; Department of Cardiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary., Czuriga D; Department of Cardiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary., Van Linthout S; Berlin Institute of Health at Charite (BIH)-Universitätmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), 13353 Berlin, Germany., Tschöpe C; Berlin Institute of Health at Charite (BIH)-Universitätmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), 13353 Berlin, Germany., Dhalla NS; Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, 351 Tache Avenue, Department of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, Canada., Mügge A; Institut für Forschung und Lehre (IFL) Molecular and Experimental Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany., Tóth A; Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, H-4032 Debrecen, Hungary., Papp Z; Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, H-4032 Debrecen, Hungary., Barta J; Department of Cardiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary., Hamdani N; Institut für Forschung und Lehre (IFL) Molecular and Experimental Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.; Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, 44801 Bochum, Germany.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2021 Jun 16; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 16.

The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung.

Autor: Castro, Claudia F. Garcia¹, Nardiello, Claudio¹, Hadzic, Stefan¹, Kojonazarov, Baktybek^1,2, Kraut, Simone¹, Gierhardt, Mareike^1,3,4, Schäffer, Julia¹, Bednorz, Mariola¹, Quanz, Karin¹, Heger, Jacqueline⁵, Korfei, Martina¹, Wilhelm, Jochen^1,2, Hecker, Matthias¹, Bartkuhn, Marek^1,2, Arnhold, Stefan⁶, Guenther, Andreas^1,7,8, Seeger, Werner^1,2,4, Schulz, Rainer⁵, Weissmann, Norbert¹, Sommer, Natascha¹ Natascha.Sommer@innere.med.uni-giessen.de

Publikováno v: Aging & Disease. Apr2024, Vol. 15 Issue 2, p911-926. 16p.

The Involvement of Reactive Oxygen Species in Causing Chronic Cardiovascular and Neurodegenerative Diseases and Some Cancers.

Autor: Tiwana, Jasneet K.¹, Shah, Anureet K.², Dhalla, Naranjan S.¹ nsdhalla@sbrc.ca

Publikováno v: Scripta Medica. Mar/Apr2024, Vol. 55 Issue 2, p199-217. 19p.