Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds.

Autor: Langron E; Research Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK., Simone MI; Discipline of Chemistry, School of Environmental and Life Sciences, Priority Research Centre for Chemical Biology and Clinical Pharmacology, The University of Newcastle, Callaghan, NSW, Australia., Delalande CM; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland., Reymond JL; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland., Selwood DL; Wolfson Institute for Biomedical Research, University College London, London, UK., Vergani P; Research Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2017 Apr; Vol. 174 (7), pp. 525-539. Date of Electronic Publication: 2017 Feb 14.