EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model

Autor: Delabar, Jean M., Gomes, Marco Antônio G.B., Fructuoso, Marta, Sarrazin, Nadège, George, Nicolas, Fleary-Roberts, Nadia, Sun, Hua, Bui, Linh Chi, Rodrigues-Lima, Fernando, Janel, Nathalie, Dairou, Julien, Maria, Edmilson J., Dodd, Robert H., Cariou, Kevin, Potier, Marie-Claude

Publikováno v: In European Journal of Medicinal Chemistry 5 February 2024 265

DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives

Autor: Neumann, Fernanda, Gourdain, Stéphanie, Albac, Christelle, Dekker, Alain D., Bui, Linh Chi, Dairou, Julien, Schmitz-Afonso, Isabelle, Hue, Nathalie, Rodrigues-Lima, Fernando, Delabar, Jean M., Potier, Marie-Claude, Le Caër, Jean-Pierre, Touboul, David, Delatour, Benoît, Cariou, Kevin, Dodd, Robert H.

Publikováno v: Scientific Reports
Scientific Reports, 2018, 8, pp.2859. ⟨10.1038/s41598-018-20984-z⟩
Scientific Reports, 8:2859. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Nature Publishing Group, 2018, 8, pp.2859. ⟨10.1038/s41598-018-20984-z⟩

International audience; Inhibition of DYRK1A kinase, produced by chromosome 21 and consequently overproduced in trisomy 21 subjects, has been suggested as a therapeutic approach to treating the cognitive deficiencies observed in Down syndrome (DS). W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1567651c2ba665159ee0e253160c218d
https://hal.sorbonne-universite.fr/hal-02292094/document

The Binding of NADH and NADPH to Bovine-Liver Glutamate Dehydrogenase.

Autor: Delabar, Jean M.¹, Martin, Stephen R.¹, Bayley, Peter M.¹

Publikováno v: European Journal of Biochemistry. 10/1/82, Vol. 127 Issue 2, p367-374. 8p.

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