Small molecule and biologic inhibitors of hepatitis C virus: a symbiotic approach

Autor: Del Vecchio Am, Sarisky Rt

Publikováno v: Mini reviews in medicinal chemistry. 6(11)

Chronic infection with hepatitis C virus (HCV) remains a global health concern. Using both in vitro and cell-based assays, a series of small molecule agents specific for the viral RNA-dependent RNA polymerase have been shown to interfere with viral R

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https://pubmed.ncbi.nlm.nih.gov/17100638

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Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations: A randomized controlled study.

Autor: Silkoff PE; Janssen Research & Development LLC, Spring House, Pa. Electronic address: philsilkoff@gmail.com., Flavin S; Janssen Research & Development LLC, Spring House, Pa., Gordon R; Janssen Research & Development LLC, Spring House, Pa., Loza MJ; Janssen Research & Development LLC, Spring House, Pa., Sterk PJ; Department of Respiratory Medicine F5-259, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands., Lutter R; Departments of Respiratory Medicine and Experimental Immunology, K0-150, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands., Diamant Z; Department of Respiratory Medicine & Allergology, Institute for Clinical Science, Skane University Hospital, Lund, and QPS Netherlands, Groningen, The Netherlands., Turner RB; Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Va., Lipworth BJ; Scottish Centre for Respiratory Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom., Proud D; Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Canada., Singh D; Centre for Respiratory Medicine and Allergy, Medicines Evaluation Unit, University Hospital of South Manchester Foundation Trust, University of Manchester, Manchester, United Kingdom., Eich A; IKF Pneumologie Frankfurt, Clinical Research Center Respiratory Diseases, Frankfurt, Germany., Backer V; Department of Respiratory Medicine, Copenhagen, Denmark., Gern JE; School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wis., Herzmann C; Research Center Borstel, Center for Clinical Studies, Borstel, Germany., Halperin SA; Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre, Halifax, Canada., Mensinga TT; QPS Netherlands, Groningen, The Netherlands., Del Vecchio AM; Janssen Research & Development LLC, Spring House, Pa., Branigan P; Janssen Research & Development LLC, Spring House, Pa., San Mateo L; Janssen Research & Development LLC, Spring House, Pa., Baribaud F; Janssen Research & Development LLC, Spring House, Pa., Barnathan ES; Janssen Research & Development LLC, Spring House, Pa., Johnston SL; Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2018 Apr; Vol. 141 (4), pp. 1220-1230. Date of Electronic Publication: 2017 Jul 20.