MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury

Autor: Jimenez Calvente, Carolina, Del Pilar, Hana, Tameda, Masahiko, Johnson, Casey D, Feldstein, Ariel E

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy, vol 28, iss 2

The granulocyte-specific microRNA-223 (miR-223) has recently emerged as a negative regulator of NOD-like receptor 3 (NLRP3) expression, a central key player in chronic hepatic injuries such as fibrotic nonalcoholic steatohepatitis (NASH), as well as

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MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury.

Autor: Jimenez Calvente C; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Del Pilar H; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Tameda M; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Johnson CD; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Feldstein AE; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Rady Children's Hospital San Diego, 3020 Children's Way, MC 5030, San Diego, CA 92103-8450, USA. Electronic address: afeldstein@ucsd.edu.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2020 Feb 05; Vol. 28 (2), pp. 653-663. Date of Electronic Publication: 2019 Sep 13.