Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Dejan Krajcar"'
1
Akademický článek
Advancing Virtual Bioequivalence for Orally Administered Drug Products: Methodology, Real-World Applications and Future Outlook
Autor: Sivacharan Kollipara, Frederico Severino Martins, Rebeka Jereb, Dejan Krajcar, Tausif Ahmed
Publikováno v: Pharmaceuticals, Vol 17, Iss 7, p 876 (2024)
Bioequivalence studies are pivotal in generic drug development wherein therapeutic equivalence is provided with an innovator product. However, bioequivalence studies represent significant complexities due to the interplay of multiple factors related
Externí odkaz: https://doaj.org/article/8b2b97b7b6c94d8384c6b9e8d5b46e52
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2
Akademický článek
Predictive Potential of Acido-Basic Properties, Solubility and Food on Bioequivalence Study Outcome: Analysis of 128 Studies
Autor: Dejan Krajcar, Rebeka Jereb, Igor Legen, Jerneja Opara, Iztok Grabnar
Publikováno v: Drugs in R&D, Vol 23, Iss 3, Pp 211-220 (2023)
Abstract Background and Objectives Risk assessment related to bioequivalence study outcome is critical for effective planning from the early stage of drug product development. The objective of this research was to evaluate the associations between so
Externí odkaz: https://doaj.org/article/b5bb7643332d44b7985aa5c0709f9467
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4
The biorelevant simulation of gastric emptying and its impact on model drug dissolution and absorption kinetics
Autor: Rebeka Jereb, Dejan Krajcar, Helena Vrbanac, Jerneja Opara, Bostjan Petek, Sandra Berglez, Igor Legen, Jurij Trontelj
Publikováno v: European journal of pharmaceutics and biopharmaceutics, str. 113-120 : Ilustr., Vol. 149, 2020
COBISS-ID: 13176839
The highly variable physiological conditions within the gastrointestinal tract can cause variable drug release and absorption from the orally administrated dosage forms. The emptying of the gastric content is one of the most critical physiological pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b910fd4d96543e526f154b703806d03
https://plus.cobiss.net/cobiss/si/en/bib/4884849
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5
Simulated migrating motor complex and its impact on the release properties of hydrophilic matrix systems
Autor: Sandra Berglez, Jurij Trontelj, Helena Vrbanac, Igor Legen, Klemen Kreft, Dejan Krajcar
Publikováno v: Journal of drug delivery science and technology, str. 1-11 : Ilustr., Vol. 55, 2020
COBISS-ID: 2045297
Following ingestion, the dosage forms are exposed to high mechanical stresses, mainly due to the movement of gastric musculature and passage through the sphincters. The generated mechanical forces can have a profound impact on the release properties
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3d66a0e4c5280feb095a1990c50f14
https://plus.cobiss.net/cobiss/si/en/bib/1554014
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6
Determining the Polymer Threshold Amount for Achieving Robust Drug Release from HPMC and HPC Matrix Tablets Containing a High-Dose BCS Class I Model Drug: In Vitro and In Vivo Studies
Autor: Polona Smrdel, Saša Baumgartner, Boštjan Markun, Uros Klancar, Dejan Krajcar, Klemen Kocevar, Igor Legen, Nataša Jeraj Kampuš
It is challenging to achieve mechanically robust drug-release profiles from hydrophilic matrices containing a high dose of a drug with good solubility. However, a mechanically robust drug release over prolonged period of time can be achieved, especia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b153b2c165d711b37c72ea52b9cdfd
https://europepmc.org/articles/PMC4370964/
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