Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Dejan, Lazarevic"'
Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors
Autor:
Lucía López, Luciano Gastón Morosi, Federica La Terza, Pierre Bourdely, Giuseppe Rospo, Roberto Amadio, Giulia Maria Piperno, Valentina Russo, Camilla Volponi, Simone Vodret, Sonal Joshi, Francesca Giannese, Dejan Lazarevic, Giovanni Germano, Patrizia Stoitzner, Alberto Bardelli, Marc Dalod, Luigia Pace, Nicoletta Caronni, Pierre Guermonprez, Federica Benvenuti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor settings. However, the impact of cross-presenting cDC1 and the potential of DC-based therapies in
Externí odkaz:
https://doaj.org/article/f7c6a9ff87e544acbdd02715c577e12b
Autor:
Lucia De Monte, Francesca Clemente, Eliana Ruggiero, Raffaella Pini, Maria Grazia Ceraolo, Marco Schiavo Lena, Chiara Balestrieri, Dejan Lazarevic, Giulio Belfiori, Stefano Crippa, Gianpaolo Balzano, Massimo Falconi, Claudio Doglioni, Chiara Bonini, Michele Reni, Maria Pia Protti
Publikováno v:
EBioMedicine, Vol 97, Iss , Pp 104819- (2023)
Summary: Background: Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis and it is characterized by predominant pro-tumor Th2-type inflammation. T follicular helper (Tfh) cells are relevant immunoregulators in cancer, and often correlate w
Externí odkaz:
https://doaj.org/article/557e74fb17e34c9f9097e11925462e49
Autor:
Laura Raccosta, Maura Marinozzi, Susan Costantini, Daniela Maggioni, Lorena Maria Ferreira, Gianfranca Corna, Paola Zordan, Angela Sorice, Diego Farinello, Silvia Bianchessi, Michela Riba, Dejan Lazarevic, Paolo Provero, Matthias Mack, Attilio Bondanza, Ivan Nalvarte, J-A Gustafsson, Valeria Ranzani, Francesco De Sanctis, Stefano Ugel, Silvère Baron, Jean-Marc A. Lobaccaro, Lorenzo Pontini, Manuela Pacciarini, Catia Traversari, Massimiliano Pagani, Vincenzo Bronte, Giovanni Sitia, Per Antonson, Andrea Brendolan, Alfredo Budillon, Vincenzo Russo
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-21 (2023)
Abstract Lipid and cholesterol metabolism play a crucial role in tumor cell behavior and in shaping the tumor microenvironment. In particular, enzymatic and non-enzymatic cholesterol metabolism, and derived metabolites control dendritic cell (DC) fun
Externí odkaz:
https://doaj.org/article/19a1cad6fabb42a1b5100c635b5364ef
Autor:
Pasquale Tomaiuolo, Ignazio Stefano Piras, Simona Baghai Sain, Chiara Picinelli, Marco Baccarin, Paola Castronovo, Marco J. Morelli, Dejan Lazarevic, Maria Luisa Scattoni, Giovanni Tonon, Antonio M. Persico
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition with onset in early childhood, still diagnosed only through clinical observation due to the lack of laboratory biomarkers. Early detection strategies would be especially useful
Externí odkaz:
https://doaj.org/article/145eb5975dc34ca795f6127c1f2c4542
Autor:
Gianna Di Sario, Valeria Rossella, Elvira Smeralda Famulari, Aurora Maurizio, Dejan Lazarevic, Francesca Giannese, Claudia Felici
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
In the last years, liquid biopsy gained increasing clinical relevance for detecting and monitoring several cancer types, being minimally invasive, highly informative and replicable over time. This revolutionary approach can be complementary and may,
Externí odkaz:
https://doaj.org/article/4341f2e21a8c429ab4ce49492478cdff
Autor:
Beatrice Cardinali, Claudia Provenzano, Mariapaola Izzo, Christine Voellenkle, Jonathan Battistini, Georgios Strimpakos, Elisabetta Golini, Silvia Mandillo, Ferdinando Scavizzi, Marcello Raspa, Alessandra Perfetti, Denisa Baci, Dejan Lazarevic, Jose Manuel Garcia-Manteiga, Geneviève Gourdon, Fabio Martelli, Germana Falcone
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 184-199 (2022)
CRISPR/Cas9-mediated therapeutic gene editing is a promising technology for durable treatment of incurable monogenic diseases such as myotonic dystrophies. Gene-editing approaches have been recently applied to in vitro and in vivo models of myotonic
Externí odkaz:
https://doaj.org/article/5d433c05d99644d685e8e224594c7bdb
Autor:
Maria Lombardi, Davide Lazzeroni, Giulia Benedetti, Gloria Bertoli, Dejan Lazarevic, Michela Riba, Francesco De Cobelli, Ornella Rimoldi, Giulia d'Amati, Iacopo Olivotto, Chiara Foglieni, Paolo Camici
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 7, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/d7ff68503ff640d5a88f15f661cdb021
Autor:
Céline Schaeffer, Claudia Izzi, Andrea Vettori, Elena Pasqualetto, Davide Cittaro, Dejan Lazarevic, Gianluca Caridi, Barbara Gnutti, Cinzia Mazza, Luca Jovine, Francesco Scolari, Luca Rampoldi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a genetically heterogeneous renal disorder leading to progressive loss of renal function. ADTKD-REN is due to rare mutations in renin, all localized in the protein leader peptid
Externí odkaz:
https://doaj.org/article/8dc16d1b7739477cbf9a5b1523e9ce60
Autor:
Rossella Zanin, Silvia Pegoraro, Gloria Ros, Yari Ciani, Silvano Piazza, Fleur Bossi, Roberta Bulla, Cristina Zennaro, Federica Tonon, Dejan Lazarevic, Elia Stupka, Riccardo Sgarra, Guidalberto Manfioletti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-23 (2019)
Abstract Background Breast cancer is the most common malignancy in women worldwide. Among the breast cancer subtypes, triple-negative breast cancer (TNBC) is the most aggressive and the most difficult to treat. One of the master regulators in TNBC pr
Externí odkaz:
https://doaj.org/article/0582c6ab490846d9a9fcc0b9faaa8700
Autor:
Laura Manuto, Marco Grazioli, Andrea Spitaleri, Paolo Fontana, Luca Bianco, Luigi Bertolotti, Martina Bado, Giorgia Mazzotti, Federico Bianca, Francesco Onelia, Giovanni Lorenzin, Fabio Simeoni, Dejan Lazarevic, Elisa Franchin, Claudia Del Vecchio, Ilaria Dorigatti, Giovanni Tonon, Daniela Maria Cirillo, Enrico Lavezzo, Andrea Crisanti, Stefano Toppo
Publikováno v:
Viruses, Vol 14, Iss 2, p 399 (2022)
In February 2020, the municipality of Vo’, a small town near Padua (Italy) was quarantined due to the first coronavirus disease 19 (COVID-19)-related death detected in Italy. To investigate the viral prevalence and clinical features, the entire pop
Externí odkaz:
https://doaj.org/article/1072e6cb6af84146b6868d3c744a4c4f