Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies

Autor: Tara Sigdel, Mark Nguyen, Juliane Liberto, Dejan Dobi, Henrik Junger, Flavio Vincenti, Zoltan Laszik, Minnie M. Sarwal

Publikováno v: Frontiers in Medicine, Vol 6 (2019)

Background: There is an urgent need to develop and implement low cost, high-throughput standardized methods for routine molecular assessment of transplant biopsies. Given the vast archive of formalin-fixed and paraffin-embedded (FFPE) tissue blocks i

Externí odkaz: https://doaj.org/article/73bb227ed52044ec8fa5a437d149261d

Rationale and design of the Kidney Precision Medicine Project

Autor: Ian H. de Boer, Charles E. Alpers, Evren U. Azeloglu, Ulysses G.J. Balis, Jonathan M. Barasch, Laura Barisoni, Kristina N. Blank, Andrew S. Bomback, Keith Brown, Pierre C. Dagher, Ashveena L. Dighe, Michael T. Eadon, Tarek M. El-Achkar, Joseph P. Gaut, Nir Hacohen, Yongqun He, Jeffrey B. Hodgin, Sanjay Jain, John A. Kellum, Krzysztof Kiryluk, Richard Knight, Zoltan G. Laszik, Chrysta Lienczewski, Laura H. Mariani, Robyn L. McClelland, Steven Menez, Dennis G. Moledina, Sean D. Mooney, John F. O’Toole, Paul M. Palevsky, Chirag R. Parikh, Emilio D. Poggio, Sylvia E. Rosas, Matthew R. Rosengart, Minnie M. Sarwal, Jennifer A. Schaub, John R. Sedor, Kumar Sharma, Becky Steck, Robert D. Toto, Olga G. Troyanskaya, Katherine R. Tuttle, Miguel A. Vazquez, Sushrut S. Waikar, Kayleen Williams, Francis Perry Wilson, Kun Zhang, Ravi Iyengar, Matthias Kretzler, Jonathan Himmelfarb, Stewart Lecker, Isaac Stillman, Sushrut Waikar, Gearoid Mcmahon, Astrid Weins, Samuel Short, Paul Hoover, Mark Aulisio, Leslie Cooperman, Leal Herlitz, John O’Toole, Emilio Poggio, John Sedor, Stacey Jolly, Paul Appelbaum, Olivia Balderes, Jonathan Barasch, Andrew Bomback, Pietro A. Canetta, Vivette D. d’Agati, Satoru Kudose, Karla Mehl, Jai Radhakrishnan, Chenhua Weng, Theodore Alexandrov, Tarek Ashkar, Daria Barwinska, Pierre Dagher, Kenneth Dunn, Michael Eadon, Michael Ferkowicz, Katherine Kelly, Timothy Sutton, Seth Winfree, Chirag Parikh, Avi Rosenberg, Pam Villalobos, Rubab Malik, Derek Fine, Mohammed Atta, Jose Manuel Monroy Trujillo, Alison Slack, Sylvia Rosas, Mark Williams, Evren Azeloglu, Cijang (John) He, Jens Hansen, Samir Parikh, Brad Rovin, Chris Anderton, Ljiljana Pasa-Tolic, Dusan Velickovic, Jessica Lukowski, George (Holt) Oliver, Joseph Ardayfio, Jack Bebiak, Taneisha Campbell, Catherine Campbell, Lynda Hayashi, Nichole Jefferson, Robert Koewler, Glenda Roberts, John Saul, Anna Shpigel, Edith Christine Stutzke, Lorenda Wright, Leslie Miegs, Roy Pinkeney, Rachel Sealfon, Olga Troyanskaya, Katherine Tuttle, Dejan Dobi, Yury Goltsev, Blue Lake, Maria Joanes, Zoltan Laszik, Andrew Schroeder, Minnie Sarwal, Tara Sigdel, Ulysses Balis, Victoria Blanc, Oliver He, Jeffrey Hodgin, Laura Mariani, Rajasree Menon, Edgar Otto, Jennifer Schaub, Sean Eddy, Michele Elder, Daniel Hall, John Kellum, Mary Kruth, Raghav Murugan, Paul Palevsky, Parmjeet Randhawa, Matthew Rosengart, Sunny Sims-Lucas, Mary Stefanick, Stacy Stull, Mitchell Tublin, Charles Alpers, Ian de Boer, Ashveena Dighe, Robyn Mcclelland, Sean Mooney, Stuart Shankland, Kristina Blank, Jonas Carson, Frederick Dowd, Zach Drager, Christopher Park, Guanshi Zhang, Shweta Bansal, Manjeri Venkatachalam, Asra Kermani, Simon Lee, Christopher Lu, Tyler Miller, Orson Moe, Harold Park, Kamalanathan Sambandam, Francisco Sanchez, Jose Torrealba, Toto Robert, Miguel Vazquez, Nancy Wang, Joe Gaut, Anitha Vijayan, Randy Luciano, Dennis Moledina, Ugwuowo Ugochukwu, Sandy Alfano

Publikováno v: Kidney Int

Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision medicine approach to prevention, diagnosis, and treatment. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507d83c11ffd710db4faf3abd2daf8da
https://europepmc.org/articles/PMC8330551/

The impact of belatacept on the phenotypic heterogeneity of renal T cell–mediated alloimmune response: The critical role of maintenance treatment and inflammatory load

Autor: John R. Greenland, Zoltan Laszik, Adeline Chen, Henrik Junger, Christopher Bowman, Sindhu Chandran, Flavio Vincenti, Dejan Dobi

Publikováno v: Clin Transplant

Belatacept offers superior long-term outcome relative to calcineurin inhibitor (CNI)-based immunosuppression. However, the higher frequency of early T cell-mediated rejection (TCMR) in belatacept-treated patients hampered the widespread adoption of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a98180f84a06c26fb862052d48985d2
https://doi.org/10.1111/ctr.14084

A reference tissue atlas for the human kidney

Autor: Tarek M. El-Achkar, Rajasree Menon, Annapurna Pamreddy, Jeffrey B. Hodgin, Brad H. Rovin, Becky Steck, Seth Winfree, Abhijit S. Naik, Yongqun He, Kumar Sharma, Michael Rose, John P. Shapiro, Evren U. Azeloglu, Kun Zhang, Samir M. Parikh, Zoltan Laszik, Blue B. Lake, Tara K. Sigdel, Theodore Alexandrov, Sanjay Jain, Guanshi Zhang, Ian H. de Boer, Edgar A. Otto, Jonathan Himmelfarb, Jens Hansen, Priyanka Rashmi, M. Todd Valerius, Rachel Sealfon, Daria Barwinska, John Cijiang He, Ravi Iyengar, Olga G. Troyanskaya, Laura Barisoni, Pierre C. Dagher, Minnie M. Sarwal, Matthias Kretzler, Lisa M. Satlin, Dejan Dobi, Christopher R. Anderton, Michael T. Eadon, Dušan Veličković

Kidney Precision Medicine Project (KPMP) is building a spatially-specified human tissue atlas at the single-cell resolution with molecular details of the kidney in health and disease. Here, we describe the construction of an integrated reference tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::064ff4960c986768bec7aa3fbc1b57f9
https://doi.org/10.1101/2020.07.23.216507

Targeted Transcriptional Profiling of Kidney Transplant Biopsies

Autor: Juliane Liberto, Tara K. Sigdel, Minnie M. Sarwal, Zoltan Laszik, Szu-Chuan Hsieh, Flavio Vincenti, Mark Nguyen, Dejan Dobi

Publikováno v: Kidney International Reports, Vol 3, Iss 3, Pp 722-731 (2018)
Sigdel, TK; Nguyen, M; Dobi, D; Hsieh, S-C; Liberto, JM; Vincenti, F; et al.(2018). Targeted Transcriptional Profiling of Kidney Transplant Biopsies.. Kidney international reports, 3(3), 722-731. doi: 10.1016/j.ekir.2018.01.014. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1118f3rj
Kidney international reports, vol 3, iss 3
Kidney International Reports

Introduction: Studies are needed to assess the quality of transcriptome analysis in paired human tissue samples preserved by different methods and different gene amplification platforms to enable data comparisons across experimenters. Methods: RNA wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75912ef740386c65e0d64ba13a7db02d
http://www.sciencedirect.com/science/article/pii/S2468024918300214