Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dejah T. Petsch"'
Publikováno v:
Tetrahedron Letters. 43:379-382
This letter describes syntheses of (−)-(7S)-and (+)-(7R)-K252a dimers wherein a convergent bis-indole-N-glycosidic coupling step was used for the resolution of the C(7) substituted (±)-aglycon. Dimerization of the derived monomers was achieved via
Autor:
Jeffrey A. Ubersax, Eiji Shimizu, Dejah T. Petsch, Anthony C. Bishop, Dina Matheos, Mark D. Rose, David O. Morgan, Justin D. Blethrow, Peter G. Schultz, Joe Z. Tsien, John L. Wood, Nathanael S. Gray, Kevan M. Shokat
Publikováno v:
Nature. 407:395-401
Protein kinases have proved to be largely resistant to the design of highly specific inhibitors, even with the aid of combinatorial chemistry. The lack of these reagents has complicated efforts to assign specific signalling roles to individual kinase
Autor:
Elizabeth M. Hawkins, Brian M. Stoltz, David R. Stover, John L. Wood, Dejah T. Petsch, Daniel Elbaum
Publikováno v:
Synthesis. 1999:1529-1533
Recent efforts in these laboratories have resulted in the development of a synthetic approach to C(7) alkyl analogs in the K252a class of indolocarbazole natural products. Synthesis of 7(R)-methyl K252a (3a) and 7-(S)-methyl K252a (3b) will be descri
Publikováno v:
Journal of the American Chemical Society. 119:9641-9651
The first total synthesis of the natural product (+)-K252a (2) has been achieved in 12 steps from commercially available materials, with a longest linear sequence of seven steps and an overall yield of 21%. The synthetic strategy employs novel rhodiu
Publikováno v:
ChemInform. 29
The first total synthesis of the natural product (+)-K252a (2) has been achieved in 12 steps from commercially available materials, with a longest linear sequence of seven steps and an overall yield of 21%. The synthetic strategy employs novel rhodiu
Autor:
Hiroshi Maruta, Kazuhiko Tamaki, Thao Nheu, John L. Wood, Ioana Drutu, Dejah T. Petsch, J. Brad Shotwell, Yumiko Hirokawa, Ryan D. White, Hong S. He
Publikováno v:
ChemInform. 32
Autor:
Yumiko Hirokawa, John L. Wood, Thao Nheu, Hiroshi Maruta,‡,§ and, Hong S. He, Ryan D. White, J. Brad Shotwell, Kazuhiko Tamaki, Ioana Drutu, Dejah T. Petsch
Publikováno v:
Organic letters. 3(11)
Recent efforts in our laboratories have resulted in a synthetic approach toward C2‘-alkylated K252a analogues via extension of a K252a cyclofuranosylation strategy. The bis-indole-N-glycosidic coupling of 6-N-(3,4-dimethoxybenzyl)-staurosporinone (