Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Deirdre Murphy Piedmonte"'
Autor:
Diandra Martinez-Cano, Rashmi Ravichandran, Huong Le, H. Edward Wong, Bharat Jagannathan, Erik J. Liu, William Bailey, Jane Yang, Kelli Matthies, Hedieh Barkhordarian, Bhavana Shah, Nithya Srinivasan, Jun Zhang, Angel Hsu, Jette Wypych, Jennitte Stevens, Deirdre Murphy Piedmonte, Les P. Miranda, Lauren Carter, Michael Murphy, Neil P. King, Neil Soice
Publikováno v:
Process Biochemistry. 129:241-256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cdb05762cb3b98d4e5226e4599710f5
https://doi.org/10.1016/j.procbio.2023.03.014
https://doi.org/10.1016/j.procbio.2023.03.014
Publikováno v:
Challenges in Protein Product Development ISBN: 9783319906010
Practical issues that arise for high concentration protein formulations can complicate manufacturing and affect injectability/device compatibility. High concentration protein formulations have an increased tendency for high solution viscosity, physic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57981a67de5d23b5675261c13469bf0d
https://doi.org/10.1007/978-3-319-90603-4_7
https://doi.org/10.1007/978-3-319-90603-4_7
Autor:
Margaret Speed Ricci, Alison Hair, Kiyoshi Fujimori, Rob Swift, Ananthakrishnan Sethuraman, Vasumathi Dharmavaram, Gary Li, Wendy Jing, Renuka Thirumangalathu, Lejla Brych, Zai-Qing Wen, Gayathri Ratnaswamy, Yasser Nashed-Samuel, Deirdre Murphy Piedmonte
Publikováno v:
Journal of Pharmaceutical Sciences. 103:1104-1114
Visible particles were unexpectedly observed in a neutral-pH placebo formulation stored in glass vials but were not observed in the same formulation composition that contained protein. The particles were identified as silica gel (SiO2) and polysorbat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf8840a3c62389ec1b5cb4cf3debf0b
https://doi.org/10.1002/jps.23871
https://doi.org/10.1002/jps.23871
Publikováno v:
Advanced Drug Delivery Reviews. 60:50-58
Neulasta (pegfilgrastim) is a PEGylated version of its parent molecule NEUPOGEN (Filgrastim). This work describes the formulation development for Neulasta (pegfilgrastim), and the analytical techniques used to monitor degradation during these studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbd3272fb5ad9292acc1e9a22e03c8f
https://doi.org/10.1016/j.addr.2007.04.017
https://doi.org/10.1016/j.addr.2007.04.017
Publikováno v:
PDA journal of pharmaceutical science and technology. 69(1)
The primary container for parenterals is usually composed of glass. Given the recent industry-wide spike in glass-related problems, assays capable of detecting glass degradation before glass-related particles are visible in solution have practical si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52596a73479d2b0df72979ef3371826b
https://pubmed.ncbi.nlm.nih.gov/25691718
https://pubmed.ncbi.nlm.nih.gov/25691718
Autor:
Shabnam, Molloy, R Matthew, Fesinmeyer, R Mathew, Fesinmeyer, Theresa, Martinez, Deirdre Murphy, Piedmonte, Piedmonte D, Murphy, Mary E Huff, Pelletier, Mary E, Pelletier, Michael J, Treuheit, Gerd R, Kleemann
Publikováno v:
Journal of pharmaceutical sciences. 104(2)
High-concentration antibody solutions (>100mg/mL) present significant challenges for formulation and process development, including formulation attributes such as increased solution viscosity, and the propensity for self-association. An additional ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71a171824291ce5bac5eb13c5979349
https://pubmed.ncbi.nlm.nih.gov/25392911
https://pubmed.ncbi.nlm.nih.gov/25392911
Autor:
Karthik Nagapudi, Gayathri Ratnaswamy, Hong Lin, Wenjin Cao, Deirdre Murphy Piedmonte, Priti Baker, Susan Hershenson, Alison Hair, Lejla Brych
Publikováno v:
Journal of pharmaceutical sciences. 104(2)
Sorbitol crystallization-induced aggregation of mAbs in the frozen state was evaluated. The effect of protein aggregation resulting from sorbitol crystallization was measured as a function of formulation variables such as protein concentration and pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8958665341836477e2aed65a2a93ed38
https://pubmed.ncbi.nlm.nih.gov/25219372
https://pubmed.ncbi.nlm.nih.gov/25219372
Publikováno v:
Therapeutic Fc-Fusion Proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::186a94281c44ddc942f64944c02e5e00
https://doi.org/10.1002/9783527675272.ch05
https://doi.org/10.1002/9783527675272.ch05
Autor:
Tian Wu, Priti Baker, Beekman Alice C, M. D. Hale, Michael Eschenberg, Merrill Seymour Goldenberg, Deirdre Murphy Piedmonte, Jian Hua Gu
Publikováno v:
Pharmaceutical research. 30(2)
A novel application of oscillatory shear rheology was used to directly monitor global phase behavior of protein formulations in the frozen state and study its correlation with physical instability of frozen protein formulations.Oscillatory rheology w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596c884c7c28a0de60e13c0694d4e334
https://pubmed.ncbi.nlm.nih.gov/23070601
https://pubmed.ncbi.nlm.nih.gov/23070601
Autor:
Heather Franey, Randal R. Ketchem, Osslund Timothy D, Min Shen, Gary Li, Feng He, Egor Trilisky, Deirdre Murphy Piedmonte, John Wendling, Francis Kinderman, Haruki Hasegawa, Riki Stevenson
Publikováno v:
The Journal of biological chemistry. 286(22)
Protein synthesis and secretion are essential to cellular life. Although secretory activities may vary in different cell types, what determines the maximum secretory capacity is inherently difficult to study. Increasing protein synthesis until reachi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f7966925849144dbbe80ebc0476931
https://pubmed.ncbi.nlm.nih.gov/21464137
https://pubmed.ncbi.nlm.nih.gov/21464137