Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Deirdre M. O'Connor"'
Autor:
Sharifah Iqball, Daniel K. Beck, Gayathri Devarajan, Cheen P. Khoo, Deirdre M. O’Connor, Scott Ellis, Efrain Guzman, Kyriacos A. Mitrophanous, Yatish Lad
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 350-366 (2023)
Neovascular age-related macular degeneration (nAMD) is a leading cause of blindness in the aging population, with vascular endothelial growth factor (VEGF) playing a key role. Treatment with recombinant anti-VEGFs is the current standard of care; how
Externí odkaz:
https://doaj.org/article/bf9e54c2315e4b6d9e5ed33512f892a1
Autor:
Eleanor M. Donnelly, Eric T. Quach, Terence M. Hillery, Brenten L. Heeke, Brooke R. Snyder, Chalonda R. Handy, Deirdre M. O'Connor, Nicholas M. Boulis, Thais Federici
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 992-998 (2012)
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, which is the leading genetic cause of mortality in children. To date no effective treatment exists for SMA. The genetic basis for SMA has been well documented as a mutatio
Externí odkaz:
https://doaj.org/article/8b865ceb2cc341f8b50a0739c7a8b385
Autor:
Deirdre M. O’Connor, Corinne A. Lutomski, Nicholas M. Boulis, Martin F. Jarrold, Anthony Donsante
Publikováno v:
Hum Gene Ther Methods
Viral vectors are complex drugs that pose a particular challenge for manufacturing. Previous studies have shown that, unlike small-molecule drugs, vector preparations do not yield a collection of identical particles. Instead, a mixture of particles t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda6acf08f14a7c9da5c1c8c47f51f54
https://europepmc.org/articles/PMC6919242/
https://europepmc.org/articles/PMC6919242/
Autor:
Nicholas M. Boulis, Chunlei Zhu, Younan Xia, Junyu Yang, Deirdre M. O’Connor, Jiajia Xue, Da Huo
Publikováno v:
ACS Applied Materials & Interfaces. 9:12299-12310
Seeding nerve guidance conduits with Schwann cells can improve the outcome of peripheral nerve injury repair. Bone marrow stem cells (BMSCs) represent a good choice of cell source as they can differentiate into Schwann cells under appropriate conditi
Autor:
Younan Xia, Kelly M. Poth, Jiajia Xue, Nathan Hardcastle, Nicholas M. Boulis, Bruna Diniz, Deirdre M. O’Connor, Anthony Donsante
Publikováno v:
Adv Healthc Mater
Nerve guidance conduits (NGCs) have the potential to replace autografts in repairing peripheral nerve injuries, but their efficacy still needs to be improved. The efficacy of NGCs may be augmented by neurotrophic factors that promote axon growth and
Publikováno v:
Trends in Molecular Medicine. 21:504-512
Gene therapy is, potentially, a powerful tool for treating neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy, Parkinson's disease (PD) and Alzheimer's disease (AD). To date, clinical trials have failed to
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Spinocerebellar ataxia 1 is an autosomal dominant disease characterized by neurodegeneration and motor dysfunction. In disease pathogenesis, polyglutamine expansion within Ataxin-1, a gene involved in transcriptional repression, causes protein nuclea
Autor:
Eric T. Quach, Thais Federici, Nicholas M. Boulis, Chalonda R. Handy, Eleanor M. Donnelly, Brooke R. Snyder, Brenten L. Heeke, Deirdre M. O’Connor, Terence M. Hillery
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 992-998 (2012)
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, which is the leading genetic cause of mortality in children. To date no effective treatment exists for SMA. The genetic basis for SMA has been well documented as a mutatio
Autor:
Deirdre M. O’Connor, Min Du, Christopher A. Lamb, Dominique Blache, Roselle L. Cripps, Abigail L. Fowden, Alison J. Forhead, Susan E. Ozanne, KL Franko, F. B. Peter Wooding, Qingwu W. Shen
Publikováno v:
The Journal of Physiology. 586:2393-2403
Leptin is an important regulator of appetite and energy expenditure in adulthood, although its role as a nutritional signal in the control of growth and metabolism before birth is poorly understood. This study investigated the effects of leptin on gr
Autor:
F. B. Peter Wooding, Alison J. Forhead, Nigel Hoggard, Abigail L. Fowden, Dominique Blache, Deirdre M. O’Connor, Emily Brookes
Publikováno v:
Endocrinology. 148:3750-3757
In developed countries, the increasing incidence of obesity is a serious health problem. Leptin exposure in the perinatal period affects long-term regulation of appetite and energy expenditure, but control of leptin production in utero is unclear. Th