Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous haemodiafiltration (CVVHDF)

Autor: Marcus Kirwan, Reema Munshi, Hannah O’Keeffe, Conor Judge, Mary Coyle, Evelyn Deasy, Yvelynne P. Kelly, Peter J. Lavin, Maria Donnelly, Deirdre M. D’Arcy

Publikováno v: Critical Care, Vol 25, Iss 1, Pp 1-9 (2021)

Abstract Background Therapeutic antibiotic dose monitoring can be particularly challenging in septic patients requiring renal replacement therapy. Our aim was to conduct an exploratory population pharmacokinetic (PK) analysis on PK of vancomycin foll

Externí odkaz: https://doaj.org/article/5ce493dafe2148308f599d7cdaa210ef

Design and Implementation of an Integrated Competency-Focused Pharmacy Programme: A Case Report

Autor: Theo J. Ryan, Tamasine Grimes, Martin C. Henman, Eimear Ní Sheachnasaigh, Máire O’Dwyer, Cicely Roche, Sheila A. Ryder, Astrid Sasse, John J. Walsh, Deirdre M. D’Arcy

Publikováno v: Pharmacy, Vol 7, Iss 3, p 121 (2019)

This paper describes the design and implementation of elements of an integrated competency-focused pharmacy programme in the School of Pharmacy and Pharmaceutical Sciences (SoPPS), Trinity College Dublin (TCD), Ireland. Following a national review of

Externí odkaz: https://doaj.org/article/b5d2d9d485044453949fa6d8497f0c83

In-Vitro Product Performance of Parenteral Drug Products: View of the USP Expert Panel

Autor: Deirdre M. D’Arcy, Matthias G. Wacker, Sandra Klein, Vivek Shah, Matthew D. Burke, Gregory Hunter, Hao Xu

Publikováno v: Dissolution Technologies. 29:204-218

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ccbc7a7efd2c9fdc32e1f0bbdc7560
https://doi.org/10.14227/dt290422p20

In vitro - in vivo relations for the parenteral liposomal formulation of Amphotericin B:A clinically relevant approach with PBPK modeling

Autor: Nikoletta Fotaki, R. Díaz de León–Ortega, Deirdre M. D’Arcy, Dimitrios A. Lamprou

Publikováno v: Díaz de León–Ortega, R, D'Arcy, D M, Lamprou, D A & Fotaki, N 2021, ' In vitro-in vivo relations for the parenteral liposomal formulation of Amphotericin B : A clinically relevant approach with PBPK modeling ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 159, pp. 177-187 . https://doi.org/10.1016/j.ejpb.2020.03.001
Díaz de León–Ortega, R, D'Arcy, D, Lamprou, D & Fotaki, N 2020, ' In vitro-in vivo relations for the parenteral liposomal formulation of Amphotericin B: A clinically relevant approach with PBPK modeling ', European Journal of Pharmaceutics and Biopharmaceutics . https://doi.org/10.1016/j.ejpb.2020.03.001

In vitro release testing is a useful tool for the quality control of controlled release parenteral formulations, but in vitro release test conditions that reflect or are able to predict the in vivo performance are advantageous. Therefore, it is impor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6fed352e75cac44a8f6920dd86b916
https://purehost.bath.ac.uk/ws/files/205357562/AmB_release_and_IVIVC_Part_2_Dr_N_Fotaki.pdf

In vitro in vivo relations for the parenteral liposomal formulation of Amphotericin B: A biorelevant and clinically relevant approach

Autor: R. Díaz de León–Ortega, Deirdre M. D’Arcy, Nikoletta Fotaki, Dimitrios A. Lamprou, Wei-Feng Xue

Publikováno v: Díaz de León–Ortega, R, D'Arcy, D M, Lamprou, D A, Xue, W F & Fotaki, N 2020, ' In vitro in vivo relations for the parenteral liposomal formulation of Amphotericin B: A biorelevant and clinically relevant approach ', European Journal of Pharmaceutics and Biopharmaceutics . https://doi.org/10.1016/j.ejpb.2020.07.025
Díaz de León–Ortega, R, D'Arcy, D M, Lamprou, D A, Xue, W F & Fotaki, N 2021, ' In vitro in vivo r elations for the parenteral liposomal formulation of Amphotericin B : A biorelevant and clinically relevant approach ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 159, pp. 188-197 . https://doi.org/10.1016/j.ejpb.2020.07.025

There is limited information on how to perform in vitro release tests for intravenously 27 administered parenteral formulations and how to relate the in vitro release with an in vivo 28 pharmacokinetic parameter after the administration of the formul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5b1cfa8f0533686aabe506755efd57
https://kar.kent.ac.uk/82714/2/1-s2.0-S0939641120302319-main.pdf