Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Deirdre Lowe"'
Autor:
Yi Yu, David Vensel, Cathy Bull, Deirdre Lowe, Hui Wu, Chang-Rung Chen, Daniel T. Dransfield, Xuibin Gu, Susan Cornell-Kennon, Nivedita Namdev, Steffi Koerner, Laurie P. Volak, Mark A. Ashwell, Jason Hill, Jianqiang Wang, Yanbin Liu, Magdi Moussa
Publikováno v:
Molecular Cancer Therapeutics. 12:B270-B270
Bruton's tyrosine kinase (BTK) is a non receptor tyrosine kinase and belongs to the SRC-related TEC subfamily. The role of BTK in the B cell receptor (BCR) signaling pathway is well defined and is critical for full activation of phospholipase-C γ an
Autor:
Chang-Rung Chen, Jean-Marc Lapierre, Jeffrey D. Szwaya, Yanbin Liu, Nivedita Namdev, Deirdre Lowe, Ron E. Savage, Cathy O. Bull, Thomas C K Chan, Mark A. Ashwell, Dennis S. France
Publikováno v:
Cancer Research. 70:4501-4501
An activating somatic mutation in BRAF kinase (V600E) is found in approximately 70% of melanomas, 50% of papillary thyroid cancers and 10% of colon cancers, fueling interest in BRAF (V600E) as a therapeutic target for cancer treatment. We have previo
Autor:
Erin Chiesa, Yi Yu, Carol Waghorne, Xiaolan Zhao, Yanbin Liu, Edward F. Chang, Deirdre Lowe, Cathy Bull, Xiubin Gu, Thomas C.K. Chan, Laura Cousens
Publikováno v:
Cancer Research. 70:2517-2517
The MAPK/ERK pathway is a cascade of serine/threonine protein kinases activated by various extracellular factors to control cell growth, differentiation, migration and death. A number of somatic mutations occur that lead to constitutive activation of