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Autor:
Deirdre Lohan-Mannion, Stephen T. Robinson, Robert E. Shangraw, Rongwei Fu, Rose M. Moriarty, Agnes Hayes
Publikováno v:
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 14(7)
Lactic acidosis occurs during orthotopic liver transplantation (OLT), especially during the anhepatic and early postreperfusion phases. Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase-1, indirectly activating mitochondrial pyruvate dehyd