Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Deirdre Cooper-Blacketer"'
Autor:
George A. Carlson, Steven G. Younkin, Linda H. Younkin, Marcus A. Westerman, Ami Mariash, Linda Kotilinek, Takeshi Kawarabayashi, Karen H. Ashe, Deirdre Cooper-Blacketer
Publikováno v:
The Journal of Neuroscience. 22:1858-1867
Transgenic mice expressing mutant amyloid precursor proteins (APPs) have provided important new information about the pathogenesis of Alzheimer's disease (AD) histopathology. However, the molecular basis of memory loss in these mice is poorly underst
Autor:
Vanessa J. Marshall, Deirdre Cooper-Blacketer, Bradley T. Hyman, Steven G. Younkin, Mark Andrew Good, Karen K. Hsiao, Paul F. Chapman, Linda H. Younkin, Michael C. Irizarry, Matt Jones, Timothy V. P. Bliss, Gail L. White
Publikováno v:
Nature neuroscience. 2(3)
We investigated synaptic communication and plasticity in hippocampal slices from mice overexpressing mutated 695-amino-acid human amyloid precursor protein (APP695SWE), which show behavioral and histopathological abnormalities simulating Alzheimer's