Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

Autor: Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-

Externí odkaz: https://doaj.org/article/e42834ed181548b18cc8c7636ddae20d

Author Correction: Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

Autor: Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/07caa5d96c2949738e0c1d2aeb44e50d

A phase IV clinical trial of gastrointestinal motility in adult patients with migraine before and after initiation of a calcitonin gene‐related peptide ligand (galcanezumab) or receptor (erenumab) antagonist

Autor: David Kudrow, Linda Nguyen, Jack Semler, Chad Stroud, Karen Samaan, Deirdre B. Hoban, Linda Wietecha, Hai‐An Hsu, Eric Pearlman

Publikováno v: Headache: The Journal of Head and Face Pain. 62:1164-1176

To compare effects of an initial dose of calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) antagonists on gastrointestinal (GI) motility in patients with migraine and to explore if the mechanistic difference contributes to GI adverse e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdc3cecb40e89e3ee6e4122272177a5
https://doi.org/10.1111/head.14390

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

Autor: Hilda Lundén-Miguel, Sara Nolbrant, Andrew F. Adler, Thomas Perlmann, Agnete Kirkeby, Yogita Sharma, Nikolaos Volakakis, Tiago Cardoso, Alessandro Fiorenzano, Linda Gillberg, Deirdre B. Hoban, Malin Parmar, Andreas Heuer, Katarina Tiklova, Åsa K. Björklund, Marcella Birtele

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications; 11(1), no 2434 (2020)
Tiklová, K, Nolbrant, S, Fiorenzano, A, Björklund, Å K, Sharma, Y, Heuer, A, Gillberg, L, Hoban, D B, Cardoso, T, Adler, A F, Birtele, M, Lundén-Miguel, H, Volakakis, N, Kirkeby, A, Perlmann, T & Parmar, M 2020, ' Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease ', Nature Communications, vol. 11, no. 1, 2434 . https://doi.org/10.1038/s41467-020-16225-5

Cell replacement is a long-standing and realistic goal for the treatment of Parkinsonʼs disease (PD). Cells for transplantation can be obtained from fetal brain tissue or from stem cells. However, after transplantation, dopamine (DA) neurons are see

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba84380e7a208ef7b381cd34bd41edd
https://doaj.org/article/e42834ed181548b18cc8c7636ddae20d

Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease

Autor: Shelby, Shrigley, Fredrik, Nilsson, Bengt, Mattsson, Alessandro, Fiorenzano, Janitha, Mudannayake, Andreas, Bruzelius, Daniella Rylander, Ottosson, Anders, Björklund, Deirdre B, Hoban, Malin, Parmar

Publikováno v: Journal of Parkinson's Disease

Background: Human induced pluripotent stem cells (hiPSCs) have been proposed as an alternative source for cell replacement therapy for Parkinson’s disease (PD) and they provide the option of using the patient’s own cells. A few studies have inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::60d7466137737ea23fd64d179d15454e
https://pubmed.ncbi.nlm.nih.gov/33361611