Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Deidre Madsen"'
Autor:
M. Jamie T.V. Cope, Lawrence Lee, Faleh Salaymeh, Stephen D. Harrison, Lance Berman, Jerry M. Buysse, Craig Park, Wade W. Benton, Lingyun Li, Deidre Madsen
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics
Hyperkalemia is a potentially life-threatening condition, and patients who have chronic kidney disease, who are diabetic, or who are taking renin–angiotensin–aldosterone system inhibitors are at increased risk. Therapeutic options for hyperkalemi
Autor:
Derek Maclean, David Matthews, Steve Harrison, James F. Blake, Anita Mistry, Mu Yongqi, Wilhelm Stahl, Deidre Madsen, Christine Taylor Brew, Diana Carreno, Fengling Liu, Martha Mayo
Publikováno v:
Pharmaceutical Research
Purpose Polymeric drugs, including patiromer (Veltassa®), bind target molecules or ions in the gut, allowing fecal elimination. Non-absorbed insoluble polymers, like patiromer, avoid common systemic drug-drug interactions (DDIs). However, the potent
Autor:
Aesop Cho, David C. Griffith, Lee Chong, Nadeem Iqbal, Padmapriya Kumaraswamy, Uma Oza, Michael N. Dudley, Karen Lolans, Maria Ludwikow, David J. Loury, Shuang Bai, Rajeshwar Singh, Andrea Blecken, Ramona Hilgenkamp, William J. Watkins, Olga Lomovskaya, Deidre Madsen, John Barnard, Negar Garizi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2802-2806
Further structure–activity relationships of a novel series of fungal efflux pump inhibitors with respect to potentiation of the activity of fluconazole against strains of C. albicans and C. glabrata over-expressing ABC-type efflux pumps are systema
Autor:
Aesop Cho, Nadeem Iqbal, Bonnie Kuo, Karen Lolans, Deidre Madsen, William J. Watkins, Negar Garizi, Rémy C. Lemoine, Renata Jankowska, Vickie Wong, Maria Ludwikow, Rajeshwar Singh, John Barnard, Lee Chong, Uma Oza, Michael N. Dudley, Thomas E. Renau, Olga Lomovskaya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5133-5137
Structure-activity relationships of a novel series of fungal efflux pump inhibitors with respect to potentiation of the activity of fluconazole against strains of Candida albicans and Candida glabrata over-expressing ABC-type efflux pumps are systema
Autor:
Yakira Landaverry, Nicole Williams, Suzanne Chamberland, Thomas E. Renau, Vrushali Tembe, Deidre Madsen, Roger Leger, Rose Yen, Keith Huie, Michael N. Dudley, Jason Z. Zhang, David A. Griffith, Renee Litman, William J. Watkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4241-4244
Following the optimization of diamine-containing efflux pump inhibitors with respect to in vitro potentiation activity, in vivo stability and acute toxicity, we addressed the question of how to control the pharmacokinetic properties of the series. Up
Autor:
Rémy C. Lemoine, William J. Watkins, Uma Oza, Olga Lomovskaya, Tomasz W. Glinka, Michael N. Dudley, Karen Lolans, Rajeshwar Singh, Jessie Yang, Deidre Madsen, Aesop Cho, Nadeem Iqbal
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(20)
The discovery of a series of quinazolinone-based fungal efflux pump inhibitors by high-throughput screening for potentiation of fluconazole in C. albicans is described. Attempts to improve the aqueous solubility of screening hits led to the discovery
Autor:
William J. Watkins, Eric M. Flamme, Deidre Madsen, Rose Yen, Yohei Ishida, Olga Lomovskaya, Kiyoshi Nakayama, Suzanne Chamberland, David A. Griffith, Michael N. Dudley, Thomas E. Renau, Toshiharu Ohta, Lubov Filonova, Roger Leger, Michael Wang, Ving J. Lee
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(16)
Conformational restriction of the ornithine residue of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595, 2) furnished bioisosteric proline derivatives that were less toxic in vivo and as active as the lead in pote