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New insights into the pro-oxidant mechanism of dehydroleucodine on Trypanosoma cruzi

Autor: Jessica Gomez, Mauro Coll, Carla Guarise, Diego Cifuente, Diego Masone, Paula Faral- Tello, María Dolores Piñeyro, Carlos Robello, Guillermo Reta, Miguel Ángel Sosa, Patricia Barrera

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is one of the most important neglected diseases in Latin America. The limited use of the current nitro-derivative-based chemotherapy highlights the need for alternative drugs and the id

Externí odkaz: https://doaj.org/article/e54e0f4cd41b4872ac4817c0320452b8

Effect of dehydroleucodine (DhL) on the acrosome reaction in sperm of Chinchilla lanigera : signalling pathways involved.

Autor: Medina MF; Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Tucumán, Argentina., Pucci A; Facultad de Ciencias Naturales, Universidad Nacional de Tucumán, San Miguel de Tucumán, Tucumán, Argentina., Pucci FJ; Miguel Lillo Foundation, Animal Morphology Institute (AMI), San Miguel de Tucumán, Tucumán, Argentina., Bühler MI; Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Tucumán, Argentina., Gramajo-Bühler MC; Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Tucumán, Argentina.; Department of Developmental Biology, Higher Institute for Biological Research, CONICET, San Miguel de Tucumán, Tucumán, Argentina.

Publikováno v: Zygote (Cambridge, England) [Zygote] 2024 Dec; Vol. 32 (6), pp. 446-451. Date of Electronic Publication: 2024 Nov 19.

The Sesquiterpene Lactone Dehydroleucodine (DhL) Affects the Growth of Cultured Epimastigotes of Trypanosoma cruzi

Autor: Brengio, Silvia D., Belmonte, Silvia A., Guerreiro, Eduardo, Giordano, Oscar S., Pietrobon, Elisa O., Sosa, Miguel A.

Publikováno v: The Journal of Parasitology, 2000 Apr 01. 86(2), 407-412.

Externí odkaz: https://www.jstor.org/stable/3284787

Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine

Autor: Paola E. Ordóñez, David E. Mery, Krishan K. Sharma, Saumyadip Nemu, William F. Reynolds, Raul G. Enriquez, Darcy C. Burns, Omar Malagón, Darin E. Jones, Monica L. Guzman, Cesar M. Compadre

Publikováno v: Molecules, Vol 25, Iss 20, p 4825 (2020)

Dehydroleucodine is a bioactive sesquiterpene lactone. Herein, four dehydroleucodine amino derivatives were synthesized using the amines proline, piperidine, morpholine, and tyramine, and spectroscopic methods and single-crystal X-ray diffraction una

Externí odkaz: https://doaj.org/article/27dc93c9ea5d4b6f8fc9e934ac2382e5