Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Dehydrodolichyl diphosphate synthase"'
Autor:
Mia Furgurson, Ayrea Hurley, Jun Han, Alexandria M. Doerfler, Ang Li, Jason C. Burton, Christoph H. Borchers, Marco De Giorgi, William R. Lagor, Rachel H. Hsu, Kalyani R. Patel, Kelsey E Jarrett
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770616831edb479aac432495d2555db3
Autor:
Huazhong Li, Rey-Ting Guo, Xuejing Yu, Tzu-Ping Ko, Lixin Ma, Lilan Zhang, Weidong Liu, Chun-Chi Chen, Jiantao Ma, Chao Zhai
Publikováno v:
Biochemical and Biophysical Research Communications. 515:621-626
The polyprenoid glycan carriers are produced by cis-prenyltransferases (cis-PTs), which function as heterodimers in metazoa and fungi or homodimers in bacteria, but both are found in plants, protista and archaea. Heterodimeric cis-PTs comprise cataly
Autor:
Reut Ifrah, Rachel Zaguri, Vladimir L. Katanaev, Offer Gerlitz, Elisheva Rhodes-Mordov, Baruch Minke, Liliana Mizrahi-Meissonnier, Tal Brandwine, Dror Sharon, Tzofia Bialistoky
Publikováno v:
Frontiers in Molecular Neuroscience, Vol. 14 (2021) P. 693967
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Frontiers in Molecular Neuroscience
Dehydrodolichyl diphosphate synthase (DHDDS) is a ubiquitously expressed enzyme that catalyzes cis-prenyl chain elongation to produce the poly-prenyl backbone of dolichol. It appears in all tissues including the nervous system and it is a highly cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2a57f6ab4c89bcbeefaf9644f5d11b
https://archive-ouverte.unige.ch/unige:154075
https://archive-ouverte.unige.ch/unige:154075
Autor:
Federico Zara, Valentina Ghirotto, Maria Stella Vari, Michele Iacomino, Vincenzo Salpietro, Gianluca Piccolo, Pasquale Striano, Francesca Marchese, Antonella Riva, Elisabetta Amadori
Publikováno v:
J Pediatr Genet
Mutations in the DHDDS gene (MIM: 617836), encoding a subunit of dehydrodolichyl diphosphate synthase complex, have been recently implicated in very rare neurodevelopmental diseases. In total, five individuals carrying two de novo mutations in DHDDS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77723700d01a64f1384ed7ae47d32796
https://europepmc.org/articles/PMC8416192/
https://europepmc.org/articles/PMC8416192/
Autor:
Mark C. Butler, Sriganesh Ramachandra Rao, Delores A. Stacks, Agnieszka Onysk, Fuguo Wu, Liliana Surmacz, Lara A. Skelton, Xiuqian Mu, Steven J. Fliesler, Ewa Swiezewska, Witold Danikiewicz, Steven J. Pittler, Grzegorz Spólnik
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101198-(2020)
iScience
iScience
Summary Dehydrodolichyl diphosphate synthase (DHDDS) catalyzes the committed step in dolichol synthesis. Recessive mutations in DHDDS cause retinitis pigmentosa (RP59), resulting in blindness. We hypothesized that rod photoreceptor-specific ablation
Autor:
Timothy W. Kraft, Sriganesh Ramachandra Rao, Steven J. Fliesler, Steven J. Pittler, Stephanie J. Davis, Delores A. Stacks, Marci L DeRamus, Cyril Nii Amankwah Nyankerh
Publikováno v:
Cells
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 771 (2020)
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 771 (2020)
Patients with certain defects in the dehydrodolichyl diphosphate synthase (DHDDS) gene (RP59
OMIM #613861) exhibit classic symptoms of retinitis pigmentosa, as well as macular changes, suggestive of retinal pigment epithelium (RPE) involvement.
OMIM #613861) exhibit classic symptoms of retinitis pigmentosa, as well as macular changes, suggestive of retinal pigment epithelium (RPE) involvement.
Autor:
Kapelushnik, Schneidman-Duhovny, Newman, Giladi, Chung, Lisnyansky Barel, Haitin, Loewenstein, Lee
Dehydrodolichyl diphosphate synthase (DHDDS) and Nogo-B receptor (NgBR) form the heteromeric human cis-prenyltransferase complex, synthesizing the precursor for the glycosyl carrier involved in N-linked protein glycosylation. In line with the importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb9c31076fb2f705370e82db1614749
https://doi.org/10.1101/787119
https://doi.org/10.1101/787119
Akademický článek
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Autor:
Sriganesh Ramachandra Rao, Steven J. Pittler, Steven J. Fliesler, Mai N. Nguyen, Pravallika Kotla
Publikováno v:
Cells
Volume 9
Issue 4
Cells, Vol 9, Iss 896, p 896 (2020)
Volume 9
Issue 4
Cells, Vol 9, Iss 896, p 896 (2020)
Dehydrodolichyl diphosphate synthase (DHDDS) is required for protein N-glycosylation in eukaryotic cells. A K42E point mutation in the DHDDS gene causes an autosomal recessive form of retinitis pigmentosa (RP59), which has been classified as a congen
Akademický článek
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