Výsledky vyhledávání - "Deheragoda, M"

Dissertation/ Thesis

An investigation into mechanisms of tumourigenesis in the intestine of novel Apc mutant mice and in the small bowel of humans with Familial Adenomatous Polyposis

Autor: Deheragoda, M. G.

This thesis examined the mechanisms underlying small intestinal tumourigenesis in experimental models and humans with a mutation in the Adenomatous Polyposis Coli gene. Mutant APC alleles found in human intestinal carcinomas retain two 20 amino acid

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564958

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Genomic investigations of unexplained acute hepatitis in children

Autor: Morfopoulou, S, Buddle, S, Torres Montaguth, OE, Atkinson, L, Guerra-Assunção, JA, Moradi Marjaneh, M, Zennezini Chiozzi, R, Storey, N, Campos, L, Hutchinson, JC, Counsell, JR, Pollara, G, Roy, S, Venturini, C, Antinao Diaz, JF, Siam, A, Tappouni, LJ, Asgarian, Z, Ng, J, Hanlon, KS, Lennon, A, McArdle, A, Czap, A, Rosenheim, J, Andrade, C, Anderson, G, Lee, JCD, Williams, R, Williams, CA, Tutill, H, Bayzid, N, Martin Bernal, LM, Macpherson, H, Montgomery, K-A, Moore, C, Templeton, K, Neill, C, Holden, M, Gunson, R, Shepherd, SJ, Shah, P, Cooray, S, Voice, M, Steele, M, Fink, C, Whittaker, TE, Santilli, G, Gissen, P, Kaufer, BB, Reich, J, Andreani, J, Simmonds, P, Alrabiah, DK, Castellano, S, Chikowore, P, Odam, M, Rampling, T, Houlihan, C, Hoschler, K, Talts, T, Celma, C, Gonzalez, S, Gallagher, E, Simmons, R, Watson, C, Mandal, S, Zambon, M, Chand, M, Hatcher, J, De, S, Baillie, K, Semple, MG, DIAMONDS Consortium, PERFORM Consortium, ISARIC 4C Investigators, Martin, J, Ushiro-Lumb, I, Noursadeghi, M, Deheragoda, M, Hadzic, N, Grammatikopoulos, T, Brown, R, Kelgeri, C, Thalassinos, K, Waddington, SN, Jacques, TS, Thomson, E, Levin, M, Brown, JR, Breuer, J

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::6795ba5b71c0ade985a1f9cf7bd26084
http://hdl.handle.net/10044/1/105327

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Akademický článek

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Modelling of the expansion of normal human colonic crypts

Autor: McDonald, SAC, Leedham, SJ, Greaves, LC, Oulcrif, D, Novelli, MR, Deheragoda, M, Turnbull, DM, Jankowski, JAZ, Wright, NA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c0996a403a23ee912864e4cfb7e45ad5
https://ora.ox.ac.uk/objects/uuid:e45b6409-f1a8-4351-b51b-3079b3e6a087

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Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations

Autor: Gutierrez-Gonzalez, L, Deheragoda, M, Elia, G, Leedham, SJ, Shankar, A, Imber, C, Jankowski, JA, Turnbull, DM, Novelli, M, Wright, NA, McDonald, SA

Little is known about the clonal structure or stem cell architecture of the human small intestinal crypt/villus unit, or how mutations spread and become fixed. Using mitochondrial DNA (mtDNA) mutations as a marker of clonal expansion of stem cell pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8b996ee944d1d89c1eb52bed9c38127f
https://doi.org/10.1002/path.2502

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The role of cell proliferation and crypt fission in adenoma aggressiveness: a comparison of ileoanal pouch and rectal adenomas in familial adenomatous polyposis

Autor: Will, OC, Deheragoda, M, Phillips, RK, Clark, SK, Tomlinson, IP

AIM: In patients with familial adenomatous polyposis (FAP), ileoanal pouch cancer is rare whereas rectal cancer is common, despite polyp initiation at the two sites being similar at the molecular level. This study investigated whether the disparity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cb14bb07894479e433958ca7685c4fc6
https://ora.ox.ac.uk/objects/uuid:67e9cc9f-ff92-4e49-88b8-53680402c472

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The C-terminus of Apc does not influence intestinal adenoma development or progression

Autor: Lewis, A, Davis, H, Deheragoda, M, Pollard, P, Nye, E, Jeffery, R, Segditsas, S, East, P, Poulsom, R, Stamp, G, Wright, N, Tomlinson, I

Adenomatous polyposis coli (APC) mutations are found in most colorectal tumours. These mutations are almost always protein-truncating, deleting both central domains that regulate Wnt signalling and C-terminal domains that interact with the cytoskelet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f118362a044a4157a800c9675647039f
https://doi.org/10.1002/path.2972

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