Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Deguo Du"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 32, Iss , Pp 101333- (2022)
The accumulation and amyloid formation of amyloid-β (Aβ) peptides is closely associated with the pathology of Alzheimer's disease. The physiological environment wherein Aβ aggregation happens is crowded with a large variety of metal ions including
Externí odkaz:
https://doaj.org/article/3e9a5f7324044fa582fae6d21a30bb26
Autor:
YashoNandini Singh, Deepika Regmi, David Ormaza, Ramya Ayyalasomayajula, Nancy Vela, Gustavo Mundim, Deguo Du, Dmitriy Minond, Maré Cudic
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The amyloid-β precursor protein (APP) undergoes proteolysis by β- and γ-secretases to form amyloid-β peptides (Aβ), which is a hallmark of Alzheimer’s disease (AD). Recent findings suggest a possible role of O-glycosylation on APP’s proteoly
Externí odkaz:
https://doaj.org/article/75168e7857ee4144bf9fbeeb27b90c16
Publikováno v:
Molecules, Vol 24, Iss 1, p 186 (2019)
Amyloid diseases, including neurodegenerative diseases such as Alzheimer’s and Parkinson’s, are linked to a poorly understood progression of protein misfolding and aggregation events that culminate in tissue-selective deposition and human patholo
Externí odkaz:
https://doaj.org/article/6113550b4b584341818de3d353bd67e2
Autor:
Deepika Regmi, Deguo Du
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ad382f96b887de1ffc5186c5572199d
https://doi.org/10.1002/alz.069451
https://doi.org/10.1002/alz.069451
Publikováno v:
ACS chemical neuroscience. 13(21)
The microtubule-associated protein tau is involved in more than 20 different neurological disorders characterized by aberrant intracellular aggregation of tau in the brain. Here, we investigated the aggregation of a novel 20-residue model peptide, ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750e55c3e5dfd644b6454bf8443fbda1
https://pubmed.ncbi.nlm.nih.gov/36219395
https://pubmed.ncbi.nlm.nih.gov/36219395
Publikováno v:
Journal of Cellular Physiology.
Abnormal deposition of tau in neurons is a hallmark of Alzheimer's disease and several other neurodegenerative disorders. In the past decades, extensive efforts have been made to explore the mechanistic pathways underlying the development of tauopath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4832259946e76c5936c9426d74f52ea7
https://doi.org/10.1002/jcp.30853
https://doi.org/10.1002/jcp.30853
Autor:
Anamaris Melendez, Deguo Du, Nitza V Falcón-Cruz, Idalia Ramos, Kyabeth M Torres, Rolando Oyola, Erika R Serrano, Ambar S Delgado
Publikováno v:
Materials Advances
Alzheimer's disease (AD) has been consistently related to the formation of senile amyloid plaques mainly composed of amyloid β (Aβ) peptides. The toxicity of Aβ aggregates has been indicated to be responsible for AD pathology. One scenario to decr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c81e84e04fa1cc9838a797f30559ae
https://doi.org/10.1039/d1ma00461a
https://doi.org/10.1039/d1ma00461a
Autor:
YashoNandini, Singh, Deepika, Regmi, David, Ormaza, Ramya, Ayyalasomayajula, Nancy, Vela, Gustavo, Mundim, Deguo, Du, Dmitriy, Minond, Maré, Cudic
Publikováno v:
Frontiers in chemistry. 10
The amyloid-β precursor protein (APP) undergoes proteolysis by β- and γ-secretases to form amyloid-β peptides (Aβ), which is a hallmark of Alzheimer's disease (AD). Recent findings suggest a possible role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff1f1a7f40a830e84c5f01e2fffa8748
https://pubmed.ncbi.nlm.nih.gov/35464218
https://pubmed.ncbi.nlm.nih.gov/35464218