Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial

Autor: Taylor, WRJ, Thriemer, K, von Seidlein, L, Yuentrakul, P, Assawariyathipat, T, Assefa, A, Auburn, S, Chand, K, Chau, NH, Cheah, PY, Dong, LT, Dhorda, M, Degaga, TS, Devine, A, Ekawati, LL, Fahmi, F, Hailu, A, Hasanzai, MA, Hien, TT, Khu, H, Ley, B, Lubell, Y, Marfurt, J, Mohammad, H, Moore, KA, Naddim, MN, Pasaribu, AP, Pasaribu, S, Promnarate, C, Rahim, AG, Sirithiranont, P, Solomon, H, Sudoyo, H, Sutanto, I, Thanh, NV, Tuyet-Trinh, NT, Waithira, N, Woyessa, A, Yamin, FY, Dondorp, A, Simpson, JA, Baird, JK, White, NJ, Day, NP, Price, RN

Publikováno v: Lancet (London, England)

Summary Background Primaquine is the only widely used drug that prevents Plasmodium vivax malaria relapses, but adherence to the standard 14-day regimen is poor. We aimed to assess the efficacy of a shorter course (7 days) of primaquine for radical c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e14424ab4fef6fcf7ef713b0c6655d75
http://europepmc.org/articles/PMC6753019

Weekly primaquine for radical cure of patients with Plasmodium vivax malaria and glucose-6-phosphate dehydrogenase deficiency.

Autor: Taylor WRJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Meagher N; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.; Department of Infectious Diseases University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Ley B; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia., Thriemer K; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia., Bancone G; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand., Satyagraha A; Eijkman Institute of Molecular Biology, Jakarta, Indonesia.8. Ethiopian Public Health Institute, Addis Ababa, Ethiopia., Assefa A; Ethiopian Public Health Institute, Addis Ababa, Ethiopia., Chand K; Oxford University Clinical Research Unit, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Chau NH; Oxford University Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Dhorda M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Degaga TS; College of Medicine & Health Sciences, Arbaminch University, Arbaminch, Ethiopia., Ekawati LL; Oxford University Clinical Research Unit, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Hailu A; College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Hasanzai MA; Health Protection and Research Organisation, Kabul, Afghanistan., Naddim MN; Health Protection and Research Organisation, Kabul, Afghanistan., Pasaribu AP; Universitas Sumatera Utara, Medan, Indonesia., Rahim AG; Nangarhar Medical Faculty, Nangarhar University, Ministry of Higher Education, Jalalabad, Afghanistan.; Health and Social Development Organization, Kabul, Afghanistan., Sutanto I; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Thanh NV; Oxford University Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Tuyet-Trinh NT; Oxford University Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Waithira N; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Woyessa A; Ethiopian Public Health Institute, Addis Ababa, Ethiopia., Dondorp A; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., von Seidlein L; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Simpson JA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia., White NJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Baird JK; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Oxford University Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Day NP; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Price RN; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Sep 06; Vol. 17 (9), pp. e0011522. Date of Electronic Publication: 2023 Sep 06 (Print Publication: 2023).

Reducing the risk of Plasmodium vivax after falciparum infections in co-endemic areas-a randomized controlled trial (PRIMA).

Autor: Thriemer K; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia. kamala.ley-thriemer@menzies.edu.au., Degaga TS; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Christian M; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia., Alam MS; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh., Ley B; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia., Hossain MS; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh., Kibria MG; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh., Tego TT; Arba Minch General Hospital, Arba Minch, Ethiopia., Abate DT; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Weston S; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia., Karahalios A; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Rajasekhar M; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Simpson JA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Rumaseb A; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia., Mnjala H; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia., Lee G; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia., Anose RT; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Kidane FG; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Woyessa A; Ethiopian Public Health Institute, Addis Ababa, Ethiopia., Baird K; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Sutanto I; Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia., Hailu A; College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Price RN; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Publikováno v: Trials [Trials] 2022 May 18; Vol. 23 (1), pp. 416. Date of Electronic Publication: 2022 May 18.