Parasite-induced T H 1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

Autor: Defranco, Anthony, Raetz, M, Hwang, SH, Wilhelm, CL, Kirkland, D, Benson, A, Sturge, CR, Mirpuri, J, Vaishnava, S, Hou, B, Defranco, AL

Publikováno v: Defranco, Anthony; Raetz, M; Hwang, SH; Wilhelm, CL; Kirkland, D; Benson, A; et al.(2013). Parasite-induced T H 1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8n35j28q

Activation of Toll-like receptors (TLRs) by pathogens triggers cytokine production and T cell activation, immune defense mechanisms that are linked to immunopathology. Here we show that IFN-γ production by CD4 + T H 1 cells during mucosal responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::2ecce0f09119293c7da897e92056d3a5
http://www.escholarship.org/uc/item/8n35j28q

A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages

Autor: Crowley, MT, Costello, PS, Fitzer-Attas, CJ, Turner, M, Meng, F, Lowell, C, Tybulewicz, VL, DeFranco, AL

Publikováno v: The Journal of experimental medicine, vol 186, iss 7

Receptors on macrophages for the Fc region of IgG (FcgammaR) mediate a number of responses important for host immunity. Signaling events necessary for these responses are likely initiated by the activation of Src-family and Syk-family tyrosine kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7e522bc86e66a0d4d9e1d8782fab7a73
https://escholarship.org/uc/item/94c16607

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