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RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia.

Autor: Matthijssens F; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Sharma ND; Department of Pediatrics, Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.; Comprehensive Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA., Nysus M; Department of Pediatrics, Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.; Comprehensive Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA., Nickl CK; Department of Pediatrics, Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.; Comprehensive Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA., Kang H; Comprehensive Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA.; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Perez DR; Comprehensive Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA.; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, USA., Lintermans B; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Van Loocke W; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Roels J; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Peirs S; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Demoen L; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Pieters T; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Reunes L; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Lammens T; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium., De Moerloose B; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium., Van Nieuwerburgh F; Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium., Deforce DL; Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium., Cheung LC; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.; School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia., Kotecha RS; Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.; School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia., Risseeuw MD; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium., Van Calenbergh S; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Laboratory for Medicinal Chemistry, Ghent University, Ghent, Belgium., Takarada T; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Yoneda Y; Department of Pharmacology, Osaka University Graduate School of Dentistry, Suita, Japan., van Delft FW; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, United Kingdom., Lock RB; Children's Cancer Institute, School of Women's and Children's Health, Lowy Cancer Centre, University of New South Wales, Sydney, New South Wales, Australia., Merkley SD; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Chigaev A; Comprehensive Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA.; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, USA., Sklar LA; Comprehensive Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA.; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, USA., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Loh ML; Department of Pediatrics, Benioff Children's Hospital, UCSF, San Francisco, California, USA., Winter SS; Cancer and Blood Disorders Program, Children's Minnesota, Minneapolis, Minnesota, USA., Hunger SP; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Goossens S; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium., Castillo EF; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Ornatowski W; Department of Medicine, University of Arizona, Tucson, Arizona, USA., Van Vlierberghe P; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Matlawska-Wasowska K; Department of Pediatrics, Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.; Comprehensive Cancer Center, University of New Mexico, Albuquerque, New Mexico, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Mar 15; Vol. 131 (6).

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