Výsledky vyhledávání - "Deetje Iggena"

Akademický článek

Multisensory input modulates memory-guided spatial navigation in humans

Autor: Deetje Iggena, Sein Jeung, Patrizia M. Maier, Christoph J. Ploner, Klaus Gramann, Carsten Finke

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)

Abstract Efficient navigation is supported by a cognitive map of space. The hippocampus plays a key role for this map by linking multimodal sensory information with spatial memory representations. However, in human navigation studies, the full range

Externí odkaz: https://doaj.org/article/cdd105c2f16241e9ae8e8f6f43e189e9

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Akademický článek

The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations

Publikováno v: EMBO Molecular Medicine, Vol 8, Iss 5, Pp 442-457 (2016)

Abstract Cancer is a disease of the genome caused by oncogene activation and tumor suppressor gene inhibition. Deep sequencing studies including large consortia such as TCGA and ICGC identified numerous tumor‐specific mutations not only in protein�

Externí odkaz: https://doaj.org/article/f493a237e7b24fe5b81baf1eb7e2e60f

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Post-encoding modulation of spatial memory consolidation by propofol

Autor: Deetje Iggena, Patrizia M. Maier, Sophia M. Häußler, Mario Menk, Heidi Olze, Matthew E. Larkum, Carsten Finke, Christoph J. Ploner

Publikováno v: Cortex. 156:1-12

Memory consolidation is a continuous transformative process between encoding and retrieval of mental representations. Recent research has shown that neural activity immediately after encoding is particularly associated with later successful retrieval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9486846bacccb601295593825f3b5a
https://doi.org/10.1016/j.cortex.2022.08.004

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Memory-guided navigation in amyotrophic lateral sclerosis

Autor: Patrizia M. Maier, Deetje Iggena, Thomas Meyer, Carsten Finke, Christoph J. Ploner

Publikováno v: Journal of Neurology.

Background Previous studies have yielded inconsistent results about hippocampal involvement in non-demented patients with amyotrophic lateral sclerosis (ALS). We hypothesized that testing of memory-guided spatial navigation i.e., a highly hippocampus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a405035d42cba764e15ffefb717f9336
https://doi.org/10.1007/s00415-023-11753-8

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Post-encoding modulation of spatial memory by a GABAA-agonist

Autor: Matthew E. Larkum, Heidi Olze, Carsten Finke, Mario Menk, Christoph J. Ploner, Patrizia M Maier, Deetje Iggena, Sophia M Haeussler

We investigated the role of the post-encoding period for consolidation of self-centered (egocentric) and world-centered (allocentric) spatial memory in neurologically normal human subjects. We used the GABAA-ergic anesthetic propofol to transiently m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::949301acb801577e53737453037fd2dd
https://doi.org/10.1101/2021.09.12.458696

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Physical activity sustains memory retrieval in dopamine-depleted mice previously treated with L-Dopa

Autor: York Winter, M. Sparenberg, Deetje Iggena, J. Rasińska, Barbara Steiner, Charlotte Klein

Publikováno v: Behavioural brain research. 369

The neurodegenerative disorder Parkinson's disease affects motor abilities as well as cognition. The gold standard therapy is L-Dopa, which mainly restores motor skills. Therefore, we require additional interventions to sustain cognitive functions in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e6bc111d4eaf807b716495817ccf5d
https://pubmed.ncbi.nlm.nih.gov/30998993

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Physical exercise counteracts MPTP-induced changes in neural precursor cell proliferation in the hippocampus and restores spatial learning but not memory performance in the water maze

Autor: Elisabeth G. Hain, Barbara Steiner, J. Rasińska, Marion Rivalan, York Winter, M. Sparenberg, Charlotte Klein, Anahita Poshtiban, L. Empl, Deetje Iggena

Publikováno v: Behavioural Brain Research. 307:227-238

Parkinson's disease (PD) is characterized by a continuous loss of dopaminergic neurons in the substantia nigra, which not only leads to characteristic motor symptoms but also to cognitive impairments. Physical exercise has been shown to improve hippo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4168529d021cb21f93826d668a19da4e
https://doi.org/10.1016/j.bbr.2016.02.040

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The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations

Publikováno v: Diederichs, S, Bartsch, L, Berkmann, J C, Fröse, K, Heitmann, J, Hoppe, C, Iggena, D, Jazmati, D, Karschnia, P, Linsenmeier, M, Maulhardt, T, Möhrmann, L, Morstein, J, Paffenholz, S V, Röpenack, P, Rückert, T, Sandig, L, Schell, M, Steinmann, A, Voss, G, Wasmuth, J, Weinberger, M E & Wullenkord, R 2016, ' The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations ', EMBO Molecular Medicine, vol. 8, no. 5, pp. 442-57 . https://doi.org/10.15252/emmm.201506055
EMBO Molecular Medicine

Cancer is a disease of the genome caused by oncogene activation and tumor suppressor gene inhibition. Deep sequencing studies including large consortia such as TCGA and ICGC identified numerous tumor‐specific mutations not only in protein‐coding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e689fba1ebc81913434045610d3eb18a
https://doi.org/10.15252/emmm.201506055

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Exercise prevents high-fat diet-induced impairment of flexible memory expression in the water maze and modulates adult hippocampal neurogenesis in mice

Autor: Charlotte Klein, W. Jonas, P. Wiedmer, Deetje Iggena, R Hellweg, Marion Rivalan, L. Empl, Barbara Steiner, Joachim Spranger, York Winter

Publikováno v: Neurobiology of learning and memory. 131

Obesity is currently one of the most serious threats to human health in the western civilization. A growing body of evidence suggests that obesity is associated with cognitive dysfunction. Physical exercise not only improves fitness but it has also b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715fb275b762508ec054a2dad82f367a
https://pubmed.ncbi.nlm.nih.gov/26968656

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Only watching others making their experiences is insufficient to enhance adult neurogenesis and water maze performance in mice

Autor: Gerd Kempermann, Barbara Steiner, York Winter, Charlotte Klein, Alexander Garthe, Deetje Iggena

Publikováno v: Scientific Reports
Scientific reports 5(1), 14141 (2015). doi:10.1038/srep14141

In the context of television consumption and its opportunity costs the question arises how far experiencing mere representations of the outer world would have the same neural and cognitive consequences than actively interacting with that environment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04a56b6847742e75b7c1bc45b388b49

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