Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Deepu Oommen"'
Publikováno v:
Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-22 (2023)
Abstract Background and aims The accumulation of misfolded proteins, encoded by genetic variants of functional genes leads to Endoplasmic Reticulum (ER) stress, which is a critical consequence in human disorders such as familial hypercholesterolemia,
Externí odkaz:
https://doaj.org/article/d9a5bfeb8a49475483a01fe270e1b6a0
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Familial hypercholesterolemia (FH) is an autosomal genetic disease characterized by high serum low-density lipoprotein (LDL) content leading to premature coronary artery disease. The main genetic and molecular causes of FH are mutations in low-densit
Externí odkaz:
https://doaj.org/article/ef9cebdfbde041f3a3fed71a0e615b44
Background and Aims- Endoplasmic Reticulum (ER) stress, caused by aberrantly trafficked proteins that are encoded by genetic variants of functional genes, is a critical consequence in human disorders such as familial hypercholesterolemia, cardiovascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95d6f866f83668bf24e66ac1f70342d6
https://doi.org/10.21203/rs.3.rs-2615406/v1
https://doi.org/10.21203/rs.3.rs-2615406/v1
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 809:43-49
Auranofin, an organogold compound classified as an anti-rheumatic agent is under phase 2 clinical trials for re-purposing to treat recurrent epithelial ovarian cancer. We have reported earlier that Breast cancer 1, early onset (BRCA1) mutant ovarian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55f3abfa08f8de32b706f3127ae68e1
https://doi.org/10.1016/j.mrgentox.2016.09.003
https://doi.org/10.1016/j.mrgentox.2016.09.003
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. :8-15
Auranofin, a thioredoxin reductase inhibitor and an anti-rheumatic drug is currently undergoing phase 2 clinical studies for repurposing to treat recurrent epithelial ovarian cancer. Previous studies have established that auranofin exerts its cytotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b545e08a56633feb98d261085e3589
https://doi.org/10.1016/j.mrfmmm.2015.11.002
https://doi.org/10.1016/j.mrfmmm.2015.11.002
Autor:
Sanjeev Gupta, Deepu Oommen, Katarzyna Mnich, Reka Chakravarthy, Adrienne M. Gorman, Karen M. Doyle, Michiel Krols, Sophie Janssens, Donna Kennedy, Afshin Samali, Leonardo Almeida-Souza, Svetlana Saveljeva, Vincent Timmerman
Publikováno v:
Cell Death and Disease
Cell Death & Disease
CELL DEATH & DISEASE
Cell Death & Disease
CELL DEATH & DISEASE
BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells overexpressing heat shock protein B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05893e9a49ecf4295112db387dbe020
https://hdl.handle.net/10067/1457320151162165141
https://hdl.handle.net/10067/1457320151162165141
Autor:
Deepu Oommen, Kevin M. Prise
Publikováno v:
Oommen, D & Prise, K M 2013, ' Down-regulation of PERK enhances resistance to ionizing radiation ', Biochemical and Biophysical Research Communications, vol. 441, no. 1, pp. 31-35 . https://doi.org/10.1016/j.bbrc.2013.09.129
Although, ionizing radiation (IR) has been implicated to cause stress in endoplasmic reticulum (ER), how ER stress signaling and major ER stress sensors modulate cellular response to IR is unclear. Protein kinase RNA-like endoplasmic reticulum kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960b18066f5442d7093351d0421ba38f
https://doi.org/10.1016/j.bbrc.2013.09.129
https://doi.org/10.1016/j.bbrc.2013.09.129
Autor:
Kevin M. Prise, Deepu Oommen
Publikováno v:
Biochemical and Biophysical Research Communications. 421:538-543
KNK437 is a benzylidene lactam compound known to inhibit stress-induced synthesis of heat shock proteins (HSPs). HSPs promote radioresistance and play a major role in stabilizing hypoxia inducible factor-1α (HIF-1α). HIF-1α is widely responsible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2934772f77558abf141f4f401af93722
https://doi.org/10.1016/j.bbrc.2012.04.040
https://doi.org/10.1016/j.bbrc.2012.04.040
The endoplasmic reticulum (ER) is the site of folding for membrane and secreted proteins. Accumulation of unfolded or misfolded proteins in the ER triggers the unfolded protein response (UPR). The UPR can promote survival by reducing the load of unfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2e761827b288e21e7f7ffc3b192d6a
A new cost effective, eye controlled method was introduced to guide and control a wheel chair for disable people, based on Electrooculography (EOG). The guidance and control is effected by eye ball movements within the socket. The system consists of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07254736b03f69ed092656378196f68