Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Deepti Lall"'
Autor:
Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M. Gittings, Deepti Lall, Benjamin E. Rabichow, Stephen Moore, Ryan Pevey, Lynette M. Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A. Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J. Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F. Gendron, Robert H. Baloh, Kendall Van Keuren-Jensen, Rita Sattler
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal cells induce or exacerbate neuronal damage. We differentiated C9orf72 ALS
Externí odkaz:
https://doaj.org/article/c5861f14d9984d6d91846ead3941a04a
Autor:
Savannah Sawaged, Thomas Mota, Honit Piplani, Reetu Thakur, Deepti Lall, Elizabeth McCabe, Soojung Seo, Fayyaz S Sutterwala, Ralph Feuer, Roberta A Gottlieb, Jon Sin
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010350 (2022)
Host-pathogen dynamics are constantly at play during enteroviral infection. Coxsackievirus B (CVB) is a common juvenile enterovirus that infects multiple organs and drives inflammatory diseases including acute pancreatitis and myocarditis. Much like
Externí odkaz:
https://doaj.org/article/e696c9c12bf5439ba9dabcd41437eaa3
Autor:
Jesús A. Pérez-Cabello, Lucía Silvera-Carrasco, Jaime M. Franco, Vivian Capilla-González, Alexandros Armaos, María Gómez-Lima, Raquel García-García, Xin Wen Yap, M. Magdalena Leal-Lasarte, Deepti Lall, Robert H. Baloh, Salvador Martínez, Yoshihiko Miyata, Gian G. Tartaglia, Ritwick Sawarkar, Mario García-Dominguez, David Pozo, Cintia Roodveldt
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease affecting motor neurons and characterized by microglia-mediated neurotoxic inflammation whose underlying mechanisms remain incompletely understood. In this work we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::009874c33f6e71a3dc6ed51509372f09
https://doi.org/10.1101/2023.01.23.524851
https://doi.org/10.1101/2023.01.23.524851
Autor:
Thomas E. Mahan, Deepti Lall, David M. Holtzman, Rita Sattler, A.K.M. Ghulam Muhammad, Michael Vazquez, Jesse Landeros, Daniel H. Geschwind, Hayk Davtyan, Ileana Lorenzini, Jacqueline G. O’Rourke, Jason D. Ulrich, Thomas A. Mota, Shaughn Bell, Junwon Kim, Jessica E. Rexach, Layla Ghaffari, Oksana Shelest, Mathew Blurton-Jones, Robert H. Baloh
Publikováno v:
Neuron, vol 109, iss 14
C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein expression and production of potentially toxic RNA and dipeptide repeat proteins. In addition to AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31b1ab4973804c5e9402cb574f064cf
https://escholarship.org/uc/item/9ws7v673
https://escholarship.org/uc/item/9ws7v673
Autor:
Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M Gittings, Deepti Lall, Benjamin E Rabichow, Stephen Moore, Ryan Pevey, Lynette Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F Gendron, Robert H Baloh, Kendall Van Keuren-Jensen, Rita Sattler
Background A mutation in the C9orf72 gene is the most common genetic mutation of familial and sporadic ALS, as well as familial FTD. While prior studies have focused on elucidating the mechanisms of neuronal dysfunction and neurodegeneration associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed9356d12a0c4f704bd87027f5bc041
https://doi.org/10.1101/2020.09.03.277459
https://doi.org/10.1101/2020.09.03.277459
Autor:
Deepti Lall, Robert H. Baloh
Publikováno v:
Journal of Clinical Investigation. 127:3250-3258
Amyotrophic lateral sclerosis (ALS) is a degenerative disorder that is characterized by loss of motor neurons and shows clinical, pathological, and genetic overlap with frontotemporal dementia (FTD). Activated microglia are a universal feature of ALS
Autor:
Alberto Yáñez, Robert H. Baloh, Xinchen Wang, Madelyn E. McCauley, Jesse Landeros, Shaughn Bell, Deepti Lall, Moshe Arditi, Janet L. Markman, Viviana Valencia, Ritchie Ho, Jacqueline G. O’Rourke, Matthew B. Harms, Mengyao Jin, Shuang Chen, A. K. M. G. Muhammad, Caroline A. Jefferies
Publikováno v:
Nature
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders that overlap in their clinical presentation, pathology and genetic origin. Autoimmune disorders are also overrepresented in both ALS and FTD, but th
Autor:
Janet Cady, Edward B. Lee, Tania F. Gendron, Jacqueline G. O’Rourke, Cathleen M. Lutz, Elaine Liu, Leonard Petrucelli, Jonah Zarrow, Dennis W. Dickson, Lillian M. Daughrity, Matthew B. Harms, Andrew Austin, Kevin J. Kim, Robert H. Baloh, Deepti Lall, Shaughn Bell, Kathryn Wu, Sharon Carmona, A. K. M. G. Muhammad, Megan Simpkinson, Sharday Grant, Laurent P. Bogdanik, Ritchie Ho
Publikováno v:
Neuron. 88(5):892-901
SummaryNoncoding expansions of a hexanucleotide repeat (GGGGCC) in the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. Here we report transgenic mice carrying a bacterial artificial chromo
Autor:
Deepti Lall
Publikováno v:
Homeostatic Control of Brain Function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1ac37c129b022d04ddd2b2fe586e5aa
https://doi.org/10.1093/med/9780199322299.003.0026
https://doi.org/10.1093/med/9780199322299.003.0026
Publikováno v:
Biochemical and biophysical research communications. 423(4)
Glycine serves as a neurotransmitter in spinal cord and brain stem, where it activates inhibitory glycine receptors. In addition, it serves as an essential co-agonist of excitatory N-methyl- d -aspartate receptors. In the central nervous system, extr