Výsledky vyhledávání - "Deepti Chugh"

Akademický článek

Neuromuscular junction dysfunction in Lafora disease

Autor: Monica Shukla, Deepti Chugh, Subramaniam Ganesh

Publikováno v: Disease Models & Mechanisms, Vol 17, Iss 10 (2024)

Externí odkaz: https://doaj.org/article/3dac52ad3302416297e53d7dda9ec81c

Akademický článek

Using reference equations to standardise incremental shuttle walk test performance in children and young people with chronic conditions and facilitate the evaluation of exercise capacity and disease severity

Autor: Eleanor Main, Melanie Bladen, Emma Raywood, Deepti Chugh, Nicole Filipow, Helen Douglas, Nicky Murray, Rachel O'Connor, Elisabeth Robinson, Nikki Thorpe

Publikováno v: BMJ Open, Vol 14, Iss 3 (2024)

Aims The aim was to evaluate whether standardised exercise performance during the incremental shuttle walk test (ISWT) can be used to assess disease severity in children and young people (CYP) with chronic conditions, through (1) identifying the most

Externí odkaz: https://doaj.org/article/d9f8871bc48e49c68ff086d252f46e55

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Akademický článek

Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice

Autor: Kaitlyn M. Kray, Vicki L. McGovern, Deepti Chugh, W. David Arnold, Arthur H.M. Burghes

Publikováno v: Neurobiology of Disease, Vol 159, Iss , Pp 105488- (2021)

Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by survival motor neuron (SMN) protein deficiency which results in motor neuron loss and muscle atrophy. SMA is caused by a mutation or deletion of the survival motor neuro

Externí odkaz: https://doaj.org/article/94f018ebc9774928b368b6ccc95ccc71

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Akademický článek

Role of fractalkine–CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain

Autor: Idrish Ali, Deepti Chugh, Christine T. Ekdahl

Publikováno v: Neurobiology of Disease, Vol 74, Iss , Pp 194-203 (2015)

Temporal lobe seizures lead to an acute inflammatory response in the brain primarily characterized by activation of parenchymal microglial cells. Simultaneously, degeneration of pyramidal cells and interneurons is evident together with a seizure-indu

Externí odkaz: https://doaj.org/article/e2ecc703b59447f0a298a69ac71f4412

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Akademický článek

Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2.

Autor: Deepti Chugh, Idrish Ali, Anahita Bakochi, Elma Bahonjic, Lars Etholm, Christine T Ekdahl

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132366 (2015)

Synapsins are pre-synaptic vesicle-associated proteins linked to the pathogenesis of epilepsy through genetic association studies in humans. Deletion of synapsins causes an excitatory/inhibitory imbalance, exemplified by the epileptic phenotype of sy

Externí odkaz: https://doaj.org/article/0c90c37cdd044dc3b848bcbc35e26ac5

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Akademický článek

Altered synaptic properties during integration of adult-born hippocampal neurons following a seizure insult.

Autor: Johanna Jackson, Deepti Chugh, Per Nilsson, James Wood, Karl Carlström, Olle Lindvall, Christine T Ekdahl

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35557 (2012)

Pathological conditions affect several stages of neurogenesis in the adult brain, including proliferation, survival, cell fate, migration, and functional integration. Here we explored how a pathological environment modulates the heterogeneous afferen

Externí odkaz: https://doaj.org/article/f3746eaf96594b60a90f20452bcd72fb

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‘Wanting no regrets’: Parental decision making around selective dorsal rhizotomy

Autor: Gillian Waite, Deepti Chugh, Stephanie Cawker, Kate Oulton, Jo Wray, Phill Harniess

Publikováno v: Child: Care, Health and Development. 49:382-391

Selective dorsal rhizotomy (SDR) is an irreversible neurosurgical procedure used to reduce spasticity while aiming to improve gross motor function for children with cerebral palsy (CP). Little research has explored the complexity of parental decision

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce43cb74dc860dbf6cdcba256133454
https://doi.org/10.1111/cch.13056

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Frontline Allied Health Professionals in a Tertiary Children’s Hospital: Moving Forward Research Capacity, Culture and Engagement

Autor: Debbie Sell, Faith Gibson, Deepti Chugh, Hortensia Gimeno, Jo Wray, Graeme O'Connor, Gillian Waite, Lucy Alderson, Lucy Pepper

Publikováno v: International Journal of Practice-based Learning in Health and Social Care. 9:29-49

Higher levels of research activity within healthcare contexts are known to result in improvements to staff and patient satisfaction as well as treatment outcomes. In the United Kingdom (UK), clinical academic careers for Allied Health Professionals (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b418d679de3c552b52b061b1cf5d03f
https://doi.org/10.18552/ijpblhsc.v9i1.692

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Intraoperative electrophysiology during single-level selective dorsal rhizotomy: technique, stimulation threshold, and response data in a series of 145 patients

Autor: Belinda H A Crowe, Philippe De Vloo, Dalila Forte, Amy S. Lee, Deepti Chugh, Ivana Jankovic, Matthew Pitt, Mark Hair, Terhi Huttunen, Kristian Aquilina, Stephanie Cawker, Lucinda Carr

Publikováno v: Journal of Neurosurgery: Pediatrics. 25:597-606

OBJECTIVESelective dorsal rhizotomy (SDR) is effective at permanently reducing spasticity in children with spastic cerebral palsy. The value of intraoperative neurophysiological monitoring in this procedure remains controversial, and its robustness h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e69a861a4c0f1f3a53ed2214d7d5f0
https://doi.org/10.3171/2019.12.peds19372

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