Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Deepti, Gadi"'
Autor:
Deepti Gadi, Stephen P. Martindale, Pui Yan Chiu, Jasneet Khalsa, Pei-Hsuan Chen, Stacey M. Fernandes, Zixu Wang, Svitlana Tyekucheva, John-Hanson Machado, David C. Fisher, Philippe Armand, Matthew S. Davids, Scott Rodig, Barbara Sherry, Jennifer R. Brown
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract PI3Kδ inhibitors are approved for the therapy of B cell malignancies, but their clinical use has been limited by unpredictable autoimmune toxicity, despite promising efficacy and evidence that toxicity is associated with improved clinical o
Externí odkaz:
https://doaj.org/article/94914f0b3bca45c9ad51c3edd14b1ac9
Autor:
Matthew S. Davids, Svitlana Tyekucheva, Vanessa Rai, David C. Fisher, James A. Lederer, Emily M. Thrash, Stacey M. Fernandes, Stephen P. Martindale, Alec Griffith, Jennifer R. Brown, Oreofe O. Odejide, Brandon Lee, Timothy Z. Lehmberg, Zixu Wang, Jon E. Arnason, Deepti Gadi, John-Hanson Machado, Philippe Armand, Alexander R. Vartanov
Publikováno v:
Leukemia. 36:723-732
Several PI3Kδ inhibitors are approved for the therapy of B cell malignancies, but their clinical use has been limited by unpredictable autoimmune toxicity. We have recently reported promising efficacy results in treating chronic lymphocytic leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb1b7abf44624c518d572011b6d869f8
https://doi.org/10.1038/s41375-021-01441-9
https://doi.org/10.1038/s41375-021-01441-9
Autor:
Deepti Gadi, Alec Griffith, Zixu Wang, Svitlana Tyekucheva, Vanessa Rai, Stacey M. Fernandes, John‐Hanson Machado, Veerendra Munugalavadla, James Lederer, Jennifer R. Brown
Publikováno v:
Br J Haematol
Phosphatidylinositol 3 kinase (PI3K) inhibitors such as idelalisib have been associated with potentially severe autoimmune toxicity. In the present study, we demonstrate that relapsed refractory patients with chronic lymphocytic leukaemia treated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76526f20201d862559fad0e3eac0763
https://europepmc.org/articles/PMC9263710/
https://europepmc.org/articles/PMC9263710/
Autor:
Deepti, Gadi, Alec, Griffith, Svitlana, Tyekucheva, Zixu, Wang, Vanessa, Rai, Alexander, Vartanov, Emily, Thrash, Stacey M, Fernandes, Timothy Z, Lehmberg, Brandon, Lee, Stephen P, Martindale, John-Hanson, Machado, Oreofe, Odejide, Philippe, Armand, David C, Fisher, Jon, Arnason, Matthew S, Davids, James A, Lederer, Jennifer R, Brown
Publikováno v:
Leukemia. 36(3)
Several PI3Kδ inhibitors are approved for the therapy of B cell malignancies, but their clinical use has been limited by unpredictable autoimmune toxicity. We have recently reported promising efficacy results in treating chronic lymphocytic leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd81a1c45e4a525cd7d71314a730b05c
https://pubmed.ncbi.nlm.nih.gov/34743191
https://pubmed.ncbi.nlm.nih.gov/34743191
Autor:
Andi Kipper, Gang Liu, Andreas Ekebergh, Frederick R. Maxfield, Michael Grigalunas, Alexander Dimmling, Matthew O'Neill, Deepti Gadi, Bruce J. Melancon, Dana Cruz, Carlos A. Gartner, Olaf Wiest, Taylor R. Quinn, Edward B. Holson, Florence F. Wagner, Nina H. Pipalia, Shu Mao, Paul Helquist
Publikováno v:
ACS pharmacologytranslational science. 4(3)
Niemann-Pick disease type C1 (NPC1) is a rare genetic cholesterol storage disorder caused by mutations in the NPC1 gene. Mutations in this transmembrane late endosome protein lead to loss of normal cholesterol efflux from late endosomes and lysosomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fb081629e5d7da2ea2a1db7c1cc3bd
https://pubmed.ncbi.nlm.nih.gov/34151204
https://pubmed.ncbi.nlm.nih.gov/34151204
Autor:
Josephine L. Klitgaard, Siddha Kasar, Deepti Gadi, Donald R. Polaski, Qiyuan Li, Matthew L. Freedman, Alexander J. Federation, Christopher J. Ott, Stacey M. Fernandes, Amanda Souza, James E. Bradner, Romina E. Lenci, Jennifer R. Brown, Matthew A. Lawlor, Logan Schwartz
Enhancer profiling is a powerful approach for discovering cis-regulatory elements that define the core transcriptional regulatory circuits of normal and malignant cells. Gene control through enhancer activity is often dominated by a subset of lineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75dbad923dceb29064f184d31c23aa8
https://europepmc.org/articles/PMC6298230/
https://europepmc.org/articles/PMC6298230/
Autor:
Deepti Gadi, Barbara Sherry, Stacey M. Fernandes, Yang Pan, Jennifer R. Brown, Alexander R. Vartanov, Svitlana Tyekucheva, Vanessa Rai, James A. Lederer, Alec Griffith, Pui Yan Chiu, Siddha Kasar
Publikováno v:
Blood. 134:1745-1745
Idelalisib and duvelisib are FDA approved oral inhibitors of PI3K delta and PI3K delta/gamma, respectively. Previously, we reported a decrease in regulatory T cells (Tregs) associated with autoimmune hepatotoxicity in untreated CLL patients receiving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24598da44d195b90d38f47e6c6d1b789
https://doi.org/10.1182/blood-2019-122961
https://doi.org/10.1182/blood-2019-122961
Autor:
Barbara Baird, Ishrat M. Khan, Biswajit Sannigrahi, Michael D. Williams, Deepti Gadi, Omotunde Olubi
Publikováno v:
Surface and Interface Analysis. 46:237-242
Electroactive nanofibers decorated with α,ω-bi-(dinitrophenylcaproic acid), abbreviated as DNP, have been prepared by electrospinning a solution of α,ω-bi[2,4-dinitrophenylcaproic][poly(ethyleneoxide)-b-poly(2-methoxystyrene)-b-poly(ethylene oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::985c658ef2a00464ba738fa91feafc13
https://doi.org/10.1002/sia.5295
https://doi.org/10.1002/sia.5295
Autor:
Alexander R. Vartanov, Stacey M. Fernandes, Emily M. McWilliams, Deepak A. Rao, Jerome Ritz, Benjamin L. Lampson, Tiago R. Matos, Deepti Gadi, Jennifer R. Brown, Siddha Kasar
Publikováno v:
Blood. 132:4413-4413
Introduction Phosphatidylinositol-3-kinase (PI3K) inhibition has emerged as a novel targeted mechanism for achieving durable remission in CLL in both the untreated and relapsed/refractory setting. Despite this profound efficacy, PI3K inhibition with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5abb8189feac0ffaa6c49364e381e22e
https://doi.org/10.1182/blood-2018-99-118734
https://doi.org/10.1182/blood-2018-99-118734
Autor:
David Holowka, Stephanie Hammond, Alice Wagenknecht-Wiesner, Norah L. Smith, Barbara Baird, Deepti Gadi
Publikováno v:
Self/Nonself. 1:133-143
Mast cell stimulation via IgE receptors causes activation of multiple processes, including Ca(2+) mobilization, granule exocytosis, and outward trafficking of recycling endosomes to the plasma membrane. We used fluorescein-conjugated cholera toxin B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c253cb024c061f37e7e80a9014f2ad8
https://doi.org/10.4161/self.1.2.11672
https://doi.org/10.4161/self.1.2.11672