Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Deepthi Sanagasetti"'
Autor:
Jaya Pratap Pinnamaneni, Vivek P. Singh, Mary B. Kim, Christopher T. Ryan, Aarthi Pugazenthi, Deepthi Sanagasetti, Megumi Mathison, Jianchang Yang, Todd K. Rosengart
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Direct cell reprogramming represents a promising new myocardial regeneration strategy involving in situ transdifferentiation of cardiac fibroblasts into induced cardiomyocytes. Adult human cells are relatively resistant to reprogramming, how
Externí odkaz:
https://doaj.org/article/134bd79bdf1646b48043120e2ac5e255
Autor:
Megumi Mathison, Deepthi Sanagasetti, Vivek P. Singh, Aarthi Pugazenthi, Jaya Pratap Pinnamaneni, Christopher T. Ryan, Jianchang Yang, Todd K. Rosengart
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Fibroblast reprogramming offers the potential for myocardial regeneration via in situ cell transdifferentiation. We explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial
Externí odkaz:
https://doaj.org/article/dd218c69e5e94d91a0439e753722da4a
Autor:
Vivek P. Singh, Jaya P. Pinnamaneni, Aarthi Pugazenthi, Deepthi Sanagasetti, Megumi Mathison, James F. Martin, Jianchang Yang, Todd K. Rosengart
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 24 (2021)
Background The conversion of fibroblasts into induced cardiomyocytes may regenerate myocardial tissue from cardiac scar through in situ cell transdifferentiation. The efficiency transdifferentiation is low, especially for human cells. We explored the
Externí odkaz:
https://doaj.org/article/03a8a14f7f4f4a2bbb8a18395c5c2fe4
Autor:
Vivek P. Singh, Jaya Pratap Pinnamaneni, Aarthi Pugazenthi, Deepthi Sanagasetti, Megumi Mathison, Kai Wang, Jianchang Yang, Todd K. Rosengart
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 12 (2020)
Background Given known inefficiencies in reprogramming of fibroblasts into mature induced cardiomyocytes (iCMs), we sought to identify small molecules that would overcome these barriers to cardiac cell transdifferentiation. Methods and Results We scr
Externí odkaz:
https://doaj.org/article/1040bbb45c734eb0ad10c5511adb548e
Autor:
Lina Yang, Li Liu, Hong Gao, Jaya Pratap Pinnamaneni, Deepthi Sanagasetti, Vivek P. Singh, Kai Wang, Megumi Mathison, Qianzi Zhang, Fengju Chen, Qianxing Mo, Todd Rosengart, Jianchang Yang
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-15 (2017)
Abstract Background The stem cell factor spalt-like transcription factor 4 (SALL4) plays important roles in normal hematopoiesis and also in leukemogenesis. We previously reported that SALL4 exerts its effect by recruiting important epigenetic factor
Externí odkaz:
https://doaj.org/article/647180c870a0465a9cb5fb808bf6b3ca
Autor:
Michela Palmieri, Rituraj Pal, Hemanth R. Nelvagal, Parisa Lotfi, Gary R. Stinnett, Michelle L. Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V. Bondar, Laura Bremner, Usama Saleem, Dennis Y. Tse, Deepthi Sanagasetti, Samuel M. Wu, Joel R. Neilson, Fred A. Pereira, Robia G. Pautler, George G. Rodney, Jonathan D. Cooper, Marco Sardiello
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis. Here authors show that trehalose, an mTOR-independent autophagy inducer, alleviates the pathological phenotypes in a mouse model of neurodegenerative disease. Trehalose
Externí odkaz:
https://doaj.org/article/9d01b8cdb7714197a5184f986c9a6f8a
Autor:
Michela Palmieri, Rituraj Pal, Hemanth R. Nelvagal, Parisa Lotfi, Gary R. Stinnett, Michelle L. Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V. Bondar, Laura Bremner, Usama Saleem, Dennis Y. Tse, Deepthi Sanagasetti, Samuel M. Wu, Joel R. Neilson, Fred A. Pereira, Robia G. Pautler, George G. Rodney, Jonathan D. Cooper, Marco Sardiello
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-3 (2017)
Nature Communications 8: Article number: 14338 (2017); Published: 6 February 2017; Updated: 13 June 2017 This Article contains errors in Figs 2 and 3, for which we apologize. In Fig. 2c, the four images were inadvertently duplicated from the images i
Externí odkaz:
https://doaj.org/article/ad88932b47944958b842a6eaf7d2a132
Autor:
Vivek P. Singh, Megumi Mathison, Vivekkumar Patel, Deepthi Sanagasetti, Brian W. Gibson, Jianchang Yang, Todd K. Rosengart
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 11 (2016)
BackgroundReprogramming of cardiac fibroblasts into induced cardiomyocyte‐like cells represents a promising potential new therapy for treating heart disease, inducing significant improvements in postinfarct ventricular function in rodent models. Be
Externí odkaz:
https://doaj.org/article/c69028691e6a473ea28cc06c59212836
Autor:
Vivek P. Singh, Megumi Mathison, Jianchang Yang, Todd K. Rosengart, Christopher T. Ryan, Deepthi Sanagasetti, Jaya Pratap Pinnamaneni, Aarthi Pugazenthi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Fibroblast reprogramming offers the potential for myocardial regeneration via in situ cell transdifferentiation. We explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial cells an
Autor:
Megumi Mathison, Aarthi Pugazenthi, Vivek P. Singh, Todd K. Rosengart, Jaya Pratap Pinnamaneni, Jianchang Yang, Deepthi Sanagasetti, Kai Wang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Given known inefficiencies in reprogramming of fibroblasts into mature induced cardiomyocytes ( iCM s), we sought to identify small molecules that would overcome these barriers to cardiac cell transdifferentiation. Methods and Results We s