Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Deepshika, Ramanan"'
FoxP3+CD4+ regulatory T cells (Tregs), essential for immunologic and organismal homeostasis, have diverse functions and corresponding gene expression programs. How the many controlling transcription factors (TFs) organize to determine Treg identity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf0c93f52cdfe3ba809598be942029c2
https://doi.org/10.1101/2023.05.18.541358
https://doi.org/10.1101/2023.05.18.541358
Autor:
Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C. Macbeth, Elyza A. Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S. Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M. Chiu, Jeffrey R. Moffitt, Ansel Hsiao, John J. Mekalanos, Christophe Benoist, Dennis L. Kasper
Publikováno v:
bioRxiv
Canonically, complement is a serum-based host defense system that protects against systemic microbial invasion. Little is known about the production and function of complement components on mucosal surfaces. Here we show gut complement component 3 (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e123493ed381fc22f2f57e2ae0c488
https://europepmc.org/articles/PMC9915568/
https://europepmc.org/articles/PMC9915568/
Autor:
Martina, Sassone-Corsi, Shalhevet, Azriel, Ariel, Simon, Deepshika, Ramanan, Adriana, Ortiz-Lopez, Felicia, Chen, Nissan, Yissachar, Diane, Mathis, Christophe, Benoist
Publikováno v:
Proceedings of the National Academy of Sciences. 119
T cells that express the transcription factor RORγ, regulatory (Treg), or conventional (Th17) are strongly influenced by intestinal symbionts. In a genetic approach to identify mechanisms underlying this influence, we performed a screen for microbia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc15e7ef5b2c304117fbaa1b8128ef15
https://doi.org/10.1073/pnas.2209624119
https://doi.org/10.1073/pnas.2209624119
Autor:
Christophe Benoist, Meenakshi Rao, Milena Rozenberg, Yiqing Yan, Shalev Itzkovitz, Diane Mathis, Munir Mosaheb, Kelly McGovern, Daniella Rastelli, Omar M. Yaghi, Brinda Vijaykumar, Tiphaine Voisin, Deepshika Ramanan, Isaac M. Chiu
Publikováno v:
Immunity. 54(3)
Summary The immune and enteric nervous (ENS) systems monitor the frontier with commensal and pathogenic microbes in the colon. We investigated whether FoxP3+ regulatory T (Treg) cells functionally interact with the ENS. Indeed, microbe-responsive ROR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cea1e6ee27fca82ea50f369776f4d6
https://pubmed.ncbi.nlm.nih.gov/33691130
https://pubmed.ncbi.nlm.nih.gov/33691130
Autor:
Serre-Yu Wong, Lauren A. Peters, Eric E. Schadt, Ken Cadwell, Maryaline Coffre, Marcus J. Hines, Luis E. Gomez, Deepshika Ramanan, Sergei B. Koralov
Publikováno v:
The Journal of Immunology. 201:1442-1451
Phenotypic differences among substrains of laboratory mice due to spontaneous mutations or pre-existing genetic variation confound the interpretation of targeted mutagenesis experiments and contribute to challenges with reproducibility across institu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa640ac5fe7206f1d12c63d3a0fe9383
https://doi.org/10.4049/jimmunol.1800014
https://doi.org/10.4049/jimmunol.1800014
Autor:
Zhen Yang, Deepshika Ramanan, Christophe Benoist, Liang Yang, Aleksandar Kostic, Diane Mathis, Esen Sefik, Silvia Galván-Peña, Dennis L. Kasper, Tatyana V. Golovkina, Meng Wu
Publikováno v:
Cell. 181(6)
At the species level, immunity depends on the selection and transmission of protective components of the immune system. A microbe-induced population of RORγ-expressing regulatory T cells (Tregs) is essential in controlling gut inflammation. We uncov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79ff24c7db5286ba91ac0d3635af7c1
https://pubmed.ncbi.nlm.nih.gov/32497500
https://pubmed.ncbi.nlm.nih.gov/32497500
Autor:
Joanna R. DiSpirito, David Zemmour, Jun Cho, Allon M. Klein, Christophe Benoist, Deepshika Ramanan, Diane Mathis, Rapolas Zilionis
Foxp3+CD4+ regulatory T cells (Tregs) accumulate in certain nonlymphoid tissues, where they control diverse aspects of organ homeostasis. Populations of tissue Tregs, as they have been termed, have transcriptomes distinct from those of their counterp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5345640e7da0d5dfa412c733c01dd67b
https://europepmc.org/articles/PMC6219455/
https://europepmc.org/articles/PMC6219455/
Autor:
Serre-Yu, Wong, Maryaline, Coffre, Deepshika, Ramanan, Marcus J, Hines, Luis E, Gomez, Lauren A, Peters, Eric E, Schadt, Sergei B, Koralov, Ken, Cadwell
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(5)
Phenotypic differences among substrains of laboratory mice due to spontaneous mutations or pre-existing genetic variation confound the interpretation of targeted mutagenesis experiments, and contribute to challenges with reproducibility across instit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96a2265fdc6feb792bb495789598f32b
https://pubmed.ncbi.nlm.nih.gov/30012848
https://pubmed.ncbi.nlm.nih.gov/30012848
Autor:
Serre-Yu Wong, Lauren A. Peters, Deepshika Ramanan, Sergei B. Koralov, Eric E. Schadt, Luis E. Gomez, Maryaline Coffre, Ken Cadwell
Phenotypic differences among substrains of laboratory mice due to spontaneous mutations or pre-existing genetic variation confound the interpretation of targeted mutagenesis experiments, and contribute to challenges with reproducibility across instit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a3f99b11f877a9c9cde97115f8fae6
https://doi.org/10.1101/242586
https://doi.org/10.1101/242586
Autor:
Ken Cadwell, Deepshika Ramanan
The intestinal epithelium is a single cell layer that facilitates the absorption of nutrients but also provides a tight barrier to prevent pathogen invasion and dissemination of commensal microbes. Specialized epithelial cells of the gastrointestinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2de0fd28ed9330be4515db3ec9358d4
https://europepmc.org/articles/PMC4861060/
https://europepmc.org/articles/PMC4861060/