Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity

Autor: Shantu Amin, Arun Sharma, Junxuan Lu, Manoj K. Pandey, Deepkamal N. Karelia, Daniel Plano, Sangyub Kim

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4966, p 4966 (2021)

Current available therapies for pancreatic ductal adenocarcinoma (PDAC) provide minimal overall survival benefits and cause severe adverse effects. We have identified a novel molecule AS-10, a selenazolidine-bis-aspirinyl derivative, that was two to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da96c92000162bfd575b7a60d099671
https://pubmed.ncbi.nlm.nih.gov/34067020

Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells

Autor: Satya Narayan, Srinivasa R. Ramisetti, Shantu Amin, Manoj K. Pandey, Deepkamal N. Karelia, Sang Y. Lee, Arun Sharma

Publikováno v: European Journal of Medicinal Chemistry. 143:1919-1930

A series of novel thio- and seleno-barbituric acid derivatives were synthesized by varying the substituents at N1 and N3 (ethyl, methyl, allyl, and phenyl), and C5 tethered with dienyl and trienyl moieties attached to substituents such as phenyl, 2-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca6b0051ef7537ec6cc27f1c1c25d19
https://doi.org/10.1016/j.ejmech.2017.11.006

Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells

Autor: Deepkamal N. Karelia, Kartick C. Pramanik, Wei Wu, Junxuan Lu, Cheng Jiang, Arun Sharma, Shantu Amin

Publikováno v: Molecular carcinogenesis. 57(8)

Previous studies have established the in vivo bioavailability and efficacious dosages of phenylbutyl isoselenocyanate (ISC-4), a selenium-substituted isothiocyanate, against mouse xenograft models of human melanoma and colorectal cancer. To explore i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4250b8b9f75a9fc819e269a2116f10
https://pubmed.ncbi.nlm.nih.gov/29668110

Abstract 5080: Decursinol intercepts LNCaP human prostate cancer xenograft growth bypassing androgen receptor-prostate specific antigen axis

Autor: Arati Sharma, Deepkamal N. Karelia, Junxuan Lu, Chongtao Qin, Cheng Jiang, Sangyub Kim

Publikováno v: Cancer Research. 79:5080-5080

The slow-growing nature of most prostate cancers (PCa) provides multiple windows of opportunity to block or delay disease progression to reduce patient suffering and mortality. This is especially true following the failure of radical prostatectomy (R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d99e036173534a28befe66992798e6a
https://doi.org/10.1158/1538-7445.am2019-5080

Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity

Autor: Parvesh Singh, Srinivasa R. Ramisetti, Shantu Amin, Arun Sharma, A. S. Prakasha Gowda, Manoj K. Pandey, Ugir Hossain Sk, Deepkamal N. Karelia

Publikováno v: European journal of medicinal chemistry. 135

Synthesis and anti-melanoma activity of novel naphthalimide isoselenocyanate (NISC) and naphthalimide selenourea (NSU) analogs are described. The novel agents were screened for growth inhibition of different human melanoma cell lines including those

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73059bb3288a6a43c18c2c7774d3e983
https://pubmed.ncbi.nlm.nih.gov/28458134