Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Deepika Vasudevan"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113863- (2024)
Summary: Reproduction is an energy-intensive process requiring systemic coordination. However, the inter-organ signaling mechanisms that relay nutrient status to modulate reproductive output are poorly understood. Here, we use Drosophila melanogaster
Externí odkaz:
https://doaj.org/article/b3ca46c8a7cc49a685d583cca0c0febf
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/a33373b62d2e456e85d7d38a42406755
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010610 (2023)
Stem cells often possess immature mitochondria with few inner membrane invaginations, which increase as stem cells differentiate. Despite this being a conserved feature across many stem cell types in numerous organisms, how and why mitochondria under
Externí odkaz:
https://doaj.org/article/ac1d5caff40945cbafa206d77c890534
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/d16e5c7e86724de89c0912ca3ce722e4
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
Metazoans have evolved various quality control mechanisms to cope with cellular stress inflicted by external and physiological conditions. ATF4 is a major effector of the integrated stress response, an evolutionarily conserved pathway that mediates a
Externí odkaz:
https://doaj.org/article/1bf2f8d073814d7eb9b706e8fa5b2e07
Autor:
Deepika Vasudevan, Sarah D. Neuman, Amy Yang, Lea Lough, Brian Brown, Arash Bashirullah, Timothy Cardozo, Hyung Don Ryoo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Translation of ATF4 mRNA is stimulated during the integrated stress response. Here the authors show that two noncanonical translation initiation factors eIF2D and DENR are required for translational induction of ATF4 mRNA in Drosophila and human cell
Externí odkaz:
https://doaj.org/article/cb19d805a6b24e2eacdacbc663f41ff9
The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila
Publikováno v:
eLife, Vol 10 (2021)
PERK is an endoplasmic reticulum (ER) transmembrane sensor that phosphorylates eIF2α to initiate the Unfolded Protein Response (UPR). eIF2α phosphorylation promotes stress-responsive gene expression most notably through the transcription factor ATF
Externí odkaz:
https://doaj.org/article/3871a8bb819e4fc58256c93679f7d1b9
Autor:
Lea Lough, Dan Sherman, Manuel Becerra-Flores, Deepika Vasudevan, Olga Lavinda, Eric Ni, Hong Wang, Hyung Don Ryoo, Raoul Tibes, Timothy Cardozo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1092- (2020)
Externí odkaz:
https://doaj.org/article/cbe1d0a197a840e29dee21cd26fc075e
Autor:
Lea Lough, Dan Sherman, Manuel Becerra-Flores, Deepika Vasudevan, Olga Lavinda, Eric Ni, Hong Wang, Hyung Don Ryoo, Raoul Tibes, Timothy Cardozo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 350-360 (2018)
Cellular stress signals activate adaptive signaling pathways of the mammalian integrated stress response (ISR), of which the unfolded protein response (UPR) is a subset. These pathways converge at the phosporylation of eIF2α. Drug-like, potent and s
Externí odkaz:
https://doaj.org/article/b2607cfd86264689b36c66533b602104
Autor:
Deepika Vasudevan, Nicholas K. Clark, Jessica Sam, Victoria C. Cotham, Beatrix Ueberheide, Michael T. Marr, II, Hyung Don Ryoo
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2039-2047 (2017)
Bacterial infection often leads to suppression of mRNA translation, but hosts are nonetheless able to express immune response genes through as yet unknown mechanisms. Here, we use a Drosophila model to demonstrate that antimicrobial peptide (AMP) pro
Externí odkaz:
https://doaj.org/article/363f9690a191425680331fa8254dcb71