Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Deepika Vaidyanathan"'
Autor:
Asher Williams, Kamil S. Gedeon, Deepika Vaidyanathan, Yanlei Yu, Cynthia H. Collins, Jonathan S. Dordick, Robert J. Linhardt, Mattheos A. G. Koffas
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-13 (2019)
Abstract Background Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to its utility as the starting material for this important
Externí odkaz:
https://doaj.org/article/153766fdafe74e05b7ab3447aaa4e4a6
Autor:
Robert J. Linhardt, Scott A. McCallum, Troy Vargason, Deepika Vaidyanathan, Jonathan S. Dordick, Xia Ke, Elena E. Paskaleva
Publikováno v:
Glycobiology
The chemoenzymatic synthesis of heparin, through a multienzyme process, represents a critical challenge in providing a safe and effective substitute for this animal-sourced anticoagulant drug. D-glucuronyl C5-epimerase (C5-epi) is an enzyme acting on
Autor:
Cynthia H. Collins, Deepika Vaidyanathan, Yanlei Yu, Jonathan S. Dordick, Asher Williams, Robert J. Linhardt, Mattheos A. G. Koffas, Kamil S. Gedeon
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-13 (2019)
Microbial Cell Factories
Microbial Cell Factories
Background Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to its utility as the starting material for this important anticoagu
Autor:
Jonathan S. Dordick, Li Fu, Robert J. Linhardt, Xinyue Liu, Shaker A. Mousa, Chao Cai, Ujjwal Bhaskar, Brady F. Cress, Fuming Zhang, Mattheos A. G. Koffas, Asher Williams, Deepika Vaidyanathan, Vandhana M‐Chari
Publikováno v:
Angewandte Chemie (International ed. in English), vol 58, iss 18
Heparin is a highly sulfated, complex polysaccharide and widely used anticoagulant pharmaceutical. In this work, we chemoenzymatically synthesized perdeuteroheparin from biosynthetically enriched heparosan precursor obtained from microbial culture in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449a492d5c53e0b0c9001e0c8a810f0c
https://escholarship.org/uc/item/35h705sb
https://escholarship.org/uc/item/35h705sb
Autor:
Robert J. Linhardt, Jonathan S. Dordick, Asher Williams, Mattheos A. G. Koffas, Deepika Vaidyanathan
Publikováno v:
Bioengineering & Translational Medicine
Heparin is an anionic polysaccharide that is widely used as a clinical anticoagulant. This glycosaminoglycan is prepared from animal tissues in metric ton quantities. Animal‐sourced heparin is also widely used in the preparation of low molecular we
Publikováno v:
The Journal of Immunology. 194:145.12-145.12
The ratio of Ag/adjuvant in a vaccine can modulate the immune response as well as side effects. We studied the effects of different doses of CfaEB, a minor-major subunit fusion of the enterotoxigenic E. coli (ETEC) CFA/I fimbriae, given ID with the a