Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Deepankar, Gahloth"'
Autor:
Deepankar Gahloth, Graham Heaven, Thomas A. Jowitt, A. Paul Mould, Jordi Bella, Clair Baldock, Philip Woodman, Lydia Tabernero
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract HD-PTP is a tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and cell migration. Central to its role is the specific recruitment of critical endosomal sorting complexes required for transport (E
Externí odkaz:
https://doaj.org/article/fb9b761d30ea4a3cbb093b0b72f678dd
Autor:
James L. Galman, Deepankar Gahloth, Fabio Parmeggiani, Iustina Slabu, David Leys, Nicholas J. Turner
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 6 (2018)
The reductive amination of prochiral ketones using biocatalysts has been of great interest to the pharmaceutical industry in the last decade for integrating novel strategies in the production of chiral building blocks with the intent of minimizing im
Externí odkaz:
https://doaj.org/article/181698b9af354475b2cc0b36ac9adada
Publikováno v:
Gahloth, D, Fisher, K, Payne, K A P, Cliff, M, Levy, C & Leys, D 2022, ' Structural and biochemical characterisation of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase ', Journal of Biological Chemistry, pp. 101771 . https://doi.org/10.1016/j.jbc.2022.101771
The ubiquitous UbiD family of reversible decarboxylases is implicated in a wide range of microbial processes and depends on the prenylated flavin mononucleotide (prFMN) cofactor for catalysis. However, only a handful of UbiD family members have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c34cebc3155e2a1c0847b69ed09453d
https://www.research.manchester.ac.uk/portal/en/publications/structural-and-biochemical-characterisation-of-the-prenylated-flavin-mononucleotidedependent-indole3carboxylic-acid-decarboxylase(1a645aa3-def4-4286-9fcc-5bca1aa0a7f5).html
https://www.research.manchester.ac.uk/portal/en/publications/structural-and-biochemical-characterisation-of-the-prenylated-flavin-mononucleotidedependent-indole3carboxylic-acid-decarboxylase(1a645aa3-def4-4286-9fcc-5bca1aa0a7f5).html
Autor:
Godwin A, Aleku, Annica, Saaret, Ruth T, Bradshaw-Allen, Sasha R, Derrington, Gabriel R, Titchiner, Irina, Gostimskaya, Deepankar, Gahloth, David A, Parker, Sam, Hay, David, Leys
Publikováno v:
Nature chemical biology. 16(11)
The direct C-H carboxylation of aromatic compounds is an attractive route to the corresponding carboxylic acids, but remains challenging under mild conditions. It has been proposed that the first step in anaerobic microbial degradation of recalcitran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79f836bfc8ca83acdbca69e2a4ae567d
https://pubmed.ncbi.nlm.nih.gov/32719558
https://pubmed.ncbi.nlm.nih.gov/32719558
Publikováno v:
Journal of biotechnology. 307
Carboxylic acid reductase (CAR) enzymes are large multi-domain proteins that catalyse the ATP- and NADPH-dependent reduction of wide range of acids to the corresponding aldehydes. This particular reaction is of considerable biotechnological interest.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0387c10b41139b78d4467707611fa1
https://pubmed.ncbi.nlm.nih.gov/31689469
https://pubmed.ncbi.nlm.nih.gov/31689469
Autor:
Stephen A, Marshall, Karl A P, Payne, Karl, Fisher, Deepankar, Gahloth, Samuel S, Bailey, Arune, Balaikaite, Annica, Saaret, Irina, Gostimskaya, Godwin, Aleku, Huanming, Huang, Stephen E J, Rigby, David, Procter, David, Leys
Publikováno v:
Methods in enzymology. 620
The recent discovery of the prenylated FMN (prFMN) cofactor has led to a renewed interest in the prFMN-dependent UbiD family of enzymes. The latter catalyses the reversible decarboxylation of alpha-beta unsaturated carboxylic acids and features widel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::078794f67c40e7afa73e102f1241ef1f
https://pubmed.ncbi.nlm.nih.gov/31072499
https://pubmed.ncbi.nlm.nih.gov/31072499
Autor:
Huan-Ming Huang, David J. Procter, Godwin A. Aleku, Arune Balaikaite, Annica Saaret, Stephen E. J. Rigby, Irina Gostimskaya, Karl A. P. Payne, David Leys, Karl Fisher, Samuel S. Bailey, Stephen A. Marshall, Deepankar Gahloth
The recent discovery of the prenylated FMN (prFMN) cofactor has led to a renewed interest in the prFMN-dependent UbiD family of enzymes. The latter catalyses the reversible decarboxylation of alpha-beta unsaturated carboxylic acids and features widel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::228a1fb4edd16998ea10c817d65ecc15
https://doi.org/10.1016/bs.mie.2019.03.022
https://doi.org/10.1016/bs.mie.2019.03.022
Autor:
Nicholas J. Weise, Fabio Parmeggiani, Deepankar Gahloth, Mark S. Dunstan, Matthew P. Thompson, Nicholas J. Turner, Syed T. Ahmed, David Leys, James L. Galman
Publikováno v:
Advanced Synthesis & Catalysis. 358:3298-3306
A practical and efficient biocatalytic synthesis of aromatic d-amino acids has been developed, based on the reductive amination of the corresponding α-keto acids via a recombinant whole cell system composed of an engineered dehydrogenase and cofacto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26bb3c8220c78cc7c17cdeb5d4cce6a8
https://doi.org/10.1002/adsc.201600682
https://doi.org/10.1002/adsc.201600682
Autor:
Nicholas J. Turner, Mark S. Dunstan, A. Hill, Daniela Quaglia, David Leys, Deepankar Gahloth, Evaldas Klumbys, Nigel S. Scrutton, Michael P. Lockhart-Cairns, Sasha R. Derrington
Publikováno v:
Gahloth, D, Dunstan, M S, Quaglia, D, Klumbys, E, Lockhart-Cairns, M P, Hill, A, Derrington, S R, Scrutton, N S, Turner, N J & Leys, D 2017, ' Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis ', Nature chemical biology, vol. 13, pp. 975-981 . https://doi.org/10.1038/nchembio.2434
Nature chemical biology
Nature chemical biology
Carboxylic acid reductase (CAR) catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes. The enzyme is related to the nonribosomal peptide synthetases, consisting of an adenylation domain fused via a peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391421accf42fd9e5ffac4e4205efe85
https://pure.manchester.ac.uk/ws/files/59204978/18692_3_merged_1496951682.pdf
https://pure.manchester.ac.uk/ws/files/59204978/18692_3_merged_1496951682.pdf
Autor:
Deepankar, Gahloth, Colin, Levy, Graham, Heaven, Flavia, Stefani, Lydia, Wunderley, Paul, Mould, Matthew J, Cliff, Jordi, Bella, Alistair J, Fielding, Philip, Woodman, Lydia, Tabernero
Publikováno v:
Structure(London, England:1993)
Summary Endosomal sorting complexes required for transport (ESCRTs) are essential for ubiquitin-dependent degradation of mitogenic receptors, a process often compromised in cancer pathologies. Sorting of ubiquinated receptors via ESCRTs is controlled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69aa7d4d40734e66b5a7a8b63a17b2fb
https://pubmed.ncbi.nlm.nih.gov/27839950
https://pubmed.ncbi.nlm.nih.gov/27839950