Proteomic analysis of Sarcoptes scabiei reveals that proteins differentially expressed between eggs and female adult stages are involved predominantly in genetic information processing, metabolism and/or host-parasite interactions.

Autor: Tao Wang, Robin B Gasser, Pasi K Korhonen, Neil D Young, Ching-Seng Ang, Nicholas A Williamson, Guangxu Ma, Gangi R Samarawickrama, Deepani D Fernando, Katja Fischer

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 12, p e0010946 (2022)

Presently, there is a dearth of proteomic data for parasitic mites and their relationship with the host animals. Here, using a high throughput LC-MS/MS-based approach, we undertook the first comprehensive, large-scale proteomic investigation of egg a

Externí odkaz: https://doaj.org/article/4105faa5812344829b19d54ab30bb242

High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite.

Autor: Pasi K Korhonen, Robin B Gasser, Guangxu Ma, Tao Wang, Andreas J Stroehlein, Neil D Young, Ching-Seng Ang, Deepani D Fernando, Hieng C Lu, Sara Taylor, Simone L Reynolds, Ehtesham Mofiz, Shivashankar H Najaraj, Harsha Gowda, Anil Madugundu, Santosh Renuse, Deborah Holt, Akhilesh Pandey, Anthony T Papenfuss, Katja Fischer

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008720 (2020)

The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity,

Externí odkaz: https://doaj.org/article/12a8e16e28484afd90780687cbffde09

Phylogenetic relationships, stage-specific expression and localisation of a unique family of inactive cysteine proteases in Sarcoptes scabiei

Autor: Deepani D. Fernando, Simone L. Reynolds, Martha Zakrzewski, Ehtesham Mofiz, Anthony T. Papenfuss, Deborah Holt, Katja Fischer

Publikováno v: Parasites & Vectors, Vol 11, Iss 1, Pp 1-12 (2018)

Abstract Background Scabies is worldwide one of the most common, yet neglected, parasitic skin infections, affecting a wide range of mammals including humans. Limited treatment options and evidence of emerging mite resistance against the currently us

Externí odkaz: https://doaj.org/article/912e129cc0c741f7bdc9a6049c2dc684

Evidence that Transcriptional Alterations in Sarcoptes scabiei Are under Tight Post-Transcriptional (microRNA) Control

Autor: Pasi K. Korhonen, Tao Wang, Neil D. Young, Gangi R. Samarawickrama, Deepani D. Fernando, Guangxu Ma, Robin B. Gasser, Katja Fischer

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9719

Here, we explored transcriptomic differences among early egg (Ee), late egg (Le) and adult female (Af) stages of the scabies mite, Sarcoptes scabiei, using an integrative bioinformatic approach. We recorded a high, negative correlation between miRNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e5f544bc92816227737b9faa81f509

An RNA Interference Tool to Silence Genes in Sarcoptes scabiei Eggs

Autor: Deepani D. Fernando, Pasi K. Korhonen, Robin B. Gasser, Katja Fischer

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 873
International Journal of Molecular Sciences, Vol 23, Iss 873, p 873 (2022)

In a quest for new interventions against scabies—a highly significant skin disease of mammals, caused by a parasitic mite Sarcoptes scabiei—we are focusing on finding new intervention targets. RNA interference (RNAi) could be an efficient functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c89db078523b5cc22415cf592b54be3