Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Deepali V. Sawant"'
Autor:
Jeremy A. Sullivan, Yusuke Tomita, Ewa Jankowska-Gan, Diego A. Lema, Matt P. Arvedson, Ashita Nair, William Bracamonte-Baran, Ying Zhou, Kristy K. Meyer, Weixiong Zhong, Deepali V. Sawant, Andrea L. Szymczak-Workman, Qianxia Zhang, Creg J. Workman, Seungpyo Hong, Dario A.A. Vignali, William J. Burlingham
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1039-1051.e5 (2020)
Summary: Interleukin-35 (IL-35) is an immunosuppressive cytokine composed of Epstein-Barr-virus-induced protein 3 (Ebi3) and IL-12α chain (p35) subunits, yet the forms that IL-35 assume and its role in peripheral tolerance remain elusive. We induce
Externí odkaz:
https://doaj.org/article/19bc2a5483074d60bb874b0ead25e86d
Autor:
Brian Belmontes, Rajkumar Noubade, Sarah A. O’Brien, Hayley Ma, Jason DeVoss, Benjamin M. Alba, Hong Tan, Jason Eng, Melissa Thomas, Kevin Cook, Deepali V. Sawant, Peng Li, Matthew Chun, Jackson G. Egen, Wendy Zhong, Anupurna Kaul, Famke Aeffner, Olivier Nolan-Stevaux, Xiaoting Wang, Markus Muenz
Publikováno v:
Science Translational Medicine. 13
Therapeutic approaches are needed to promote T cell-mediated destruction of poorly immunogenic, "cold" tumors typically associated with minimal response to immune checkpoint blockade (ICB) therapy. Bispecific T cell engager (BiTE) molecules induce re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3186549e7ccd8cfb6494764a71f7cab2
https://doi.org/10.1126/scitranslmed.abd1524
https://doi.org/10.1126/scitranslmed.abd1524
Autor:
Chang Liu, Robert Lafyatis, Qianxia Zhang, David B. Corry, Mengting Liao, Tracy Tabib, Derrick J Callahan, Tao Sun, Wei Chen, Arjun Pennathur, Dario A. A. Vignali, Hiroshi Yano, Zhe Sun, Maria Chikina, Creg J. Workman, James D. Luketich, Tullia C. Bruno, Amanda C. Poholek, Deepali V. Sawant
Publikováno v:
Nature Immunology. 20:724-735
Regulatory T cells (Treg cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. Treg cells subvert beneficial anti-tumor immunity by modulating inhibitory receptor expression on tumor-infiltrating lymphocytes (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da7198bb699d845bafaf82266a0c58b3
https://doi.org/10.1038/s41590-019-0346-9
https://doi.org/10.1038/s41590-019-0346-9
Autor:
Zhiyu Huang, Antony Symons, Laura Sekirov, Boxi Kang, Dan Wolak, Nathan Pierce, Wenjun Ouyang, Jason DeVoss, Deepali V. Sawant, Xian Liu, Zemin Zhang, Kristy Perez, Liangtao Zheng, Julie Y. Huang, Paolo Manzanillo, Dev Bhatt
Publikováno v:
The Journal of Experimental Medicine
Single cell RNAseq analyses were performed on T cells from MC38 and CT26 tumor models. PCA-based sub-clustering and STARTRAC analyses revealed fine-tuned T cell subsets and dynamic in tumor. CCR8 was identified as a novel target on Tregs to synergize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430731e8ed0ed8f2fda88039ced175c8
https://doi.org/10.1084/jem.20201329
https://doi.org/10.1084/jem.20201329
Publikováno v:
Journal of Biological Methods
Bone marrow chimeras represent a key tool employed to understand biological contributions stemming from the hematopoietic versus the stromal compartment. In most institutions, cesium irradiators are used to lethally irradiate recipient animals prior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c5c8959b48a2392f4d5e16043eaff2
http://europepmc.org/articles/PMC7082502
http://europepmc.org/articles/PMC7082502
Autor:
Shan Wang, Aaron S. Rapaport, Yao He, Daniel Lu, Xin Yu, Lynn Wang, Yingjiang Ye, Jackson G. Egen, Xueda Hu, Qiao Fang, Ranran Gao, Lei Zhang, Xianwen Ren, Jessica Orf, Aeryon Kim, Wenjun Ouyang, Qiming Zhang, Deepali V. Sawant, Wei Zhang, Chi-Ming Li, Katarzyna M. Skrzypczynska, Kristy Perez, Zhanlong Shen, Jiajinlong Kang, Ziyi Li, Dev Bhatt, Sarah A. O’Brien, Zemin Zhang, Tao Wang
Publikováno v:
Cell. 181(2)
Summary Single-cell RNA sequencing (scRNA-seq) is a powerful tool for defining cellular diversity in tumors, but its application toward dissecting mechanisms underlying immune-modulating therapies is scarce. We performed scRNA-seq analyses on immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f10ee6281c35f8c27814bd2d55cf91
https://pubmed.ncbi.nlm.nih.gov/32302573
https://pubmed.ncbi.nlm.nih.gov/32302573
Autor:
Deepali V, Sawant, Hiroshi, Yano, Maria, Chikina, Qianxia, Zhang, Mengting, Liao, Chang, Liu, Derrick J, Callahan, Zhe, Sun, Tao, Sun, Tracy, Tabib, Arjun, Pennathur, David B, Corry, James D, Luketich, Robert, Lafyatis, Wei, Chen, Amanda C, Poholek, Tullia C, Bruno, Creg J, Workman, Dario A A, Vignali
Publikováno v:
Nature immunology. 20(6)
Regulatory T cells (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6bae1cee87d188cffc1793a6f651a54
https://pubmed.ncbi.nlm.nih.gov/31011189
https://pubmed.ncbi.nlm.nih.gov/31011189
Autor:
Meghan E. Turnis, Hiroshi Yano, Lawrence P. Andrews, Amy J. Beres, Deepali V. Sawant, Creg J. Workman, Dario A. A. Vignali, Greg M. Delgoffe, Andrea L. Szymczak-Workman, Peter Vogel
Publikováno v:
Immunity. 44:316-329
Summary Regulatory T (Treg) cells pose a major barrier to effective anti-tumor immunity. Although Treg cell depletion enhances tumor rejection, the ensuing autoimmune sequelae limits its utility in the clinic and highlights the need for limiting Treg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1766c8b8b72889e7b016ccb4f59328
https://doi.org/10.1016/j.immuni.2016.01.013
https://doi.org/10.1016/j.immuni.2016.01.013
Publikováno v:
Journal of Interferon & Cytokine Research
Counter-regulation afforded by specialized regulatory cell populations and immunosuppressive cytokines is critical for balancing immune outcome. The inhibitory potential of the established suppressive cytokines, IL-10 and TGFβ, has been well elucida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db92ca0483628f80f41ddf591c45adc
https://doi.org/10.1089/jir.2015.0015
https://doi.org/10.1089/jir.2015.0015
Autor:
Asha Pillai, Meifen Lu, E Shuyu, Jerold E. Rehg, Dario A. A. Vignali, Peter Vogel, Laura J. Janke, Deepali V. Sawant, Dorothy Bush, David M. Gravano
Publikováno v:
Vet Pathol
Only 2 major mast cell (MC) subtypes are commonly recognized in the mouse: the large connective tissue mast cells (CTMCs) and the mucosal mast cells (MMCs). Interepithelial mucosal inflammatory cells, most commonly identified as globule leukocytes (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34ba1e48df060251d10f68f10dfef55
https://pubmed.ncbi.nlm.nih.gov/28494703
https://pubmed.ncbi.nlm.nih.gov/28494703