Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Deepali Phadke"'
Autor:
Joy Wang, Deepali Phadke, James E. Dowling, Thomas Engber, Eman Ayyub, Xiaowei Jin, Petter Russell C, Kurt Van Vloten, Jeffrey Vessels, Chang He Xi, Serajul Haque, Gnanasambandam Kumaravel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4809-4813
Potent and selective antagonists of the adenosine A2A receptor often contain a nitrogen-rich fused-ring heterocyclic core. Replacement of the core with an isomeric ring system has previously been shown to improve target affinity, selectivity, and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c938546ec38ee5174c45c51f5b3cbef9
https://doi.org/10.1016/j.bmcl.2005.07.052
https://doi.org/10.1016/j.bmcl.2005.07.052
Autor:
Thomas Engber, Gnanasambandam Kumaravel, Pamela Shields, Xiaowei Jin, Chi Vu, Eman Ayyub, Joy Wang, Deepali Phadke, Bo Peng, Petter Russell C
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4835-4838
Piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine have recently been shown to be potent and selective adenosine A(2a) receptor antagonists. We now demonstrate that potent and selective A(2a) receptor antagonists could still be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2017e2de719481b84ee4a02a2c9b3bcc
https://doi.org/10.1016/j.bmcl.2004.07.048
https://doi.org/10.1016/j.bmcl.2004.07.048
Autor:
Chi Vu, Petter Russell C, Li Sha, Thomas Engber, Bo Peng, Xiaowei Jin, Deborah Pan, Carol Huang, Jennifer Reilly, Gnanasambandam Kumaravel, Stacy Tam, Deepali Phadke
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4831-4834
Piperazine and (R)-2-(aminomethyl)pyrrolidine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine have recently been shown to be potent and selective adenosine A(2a) receptor antagonists. We have replaced the triazolotriazine core structure with two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951f299fe51efd0a01c5da3e154c2656
https://doi.org/10.1016/j.bmcl.2004.07.047
https://doi.org/10.1016/j.bmcl.2004.07.047
Autor:
Jennifer Reilly, Thomas Engber, Xiaowei Jin, Gregg Hetu, Gnanasambandam Kumaravel, Stacy Tam, Deepali Phadke, Carol Huang, Chi Vu, Donna Grant, Deborah Pan, Glenn Smits, Petter Russell C, Bo Peng
Publikováno v:
Journal of medicinal chemistry. 48(6)
The [1,2,4]triazolo[1,5-a]triazine derivative 3, more commonly known in the field of adenosine research as ZM-241385, has previously been demonstrated to be a potent and selective adenosine A2a receptor antagonist, although with limited oral bioavail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e84058ce36c2d930d67a342bc85ec2b
https://pubmed.ncbi.nlm.nih.gov/15771443
https://pubmed.ncbi.nlm.nih.gov/15771443
Autor:
Chi B. Vu, Bo Peng, Gnanasambandam Kumaravel, Glenn Smits, Xiaowei Jin, Deepali Phadke, Thomas Engber, Carol Huang, Jennifer Reilly, Stacy Tam, Donna Grant, Gregg Hetu, Liqing Chen, Jianbo Zhang, Russell C. Petter
Publikováno v:
Journal of medicinal chemistry. 47(17)
The [1,2,4]triazolo[1,5-a]triazine derivative 3, more commonly known in the field of adenosine research as ZM-241385, has previously been demonstrated to be a potent and selective adenosine A2a receptor antagonist, although with limited oral bioavail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72daea27d8a150ec90480e3b56361ef
https://pubmed.ncbi.nlm.nih.gov/15294001
https://pubmed.ncbi.nlm.nih.gov/15294001