Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Deepali Sachdev"'
Autor:
Kelly Aukes, Cynthia Forsman, Nicholas J Brady, Kristina Astleford, Nicholas Blixt, Deepali Sachdev, Eric D Jensen, Kim C Mansky, Kathryn L Schwertfeger
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185736 (2017)
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in promoting breast cancer growth and progression. While the autocrine effects of FGFR activation in tumor cells have been extensively studied, little is known about th
Externí odkaz:
https://doaj.org/article/0dc75211c3cd4a759daffe9e22067f0b
Autor:
Xin Huang, Haein Park, Joseph Greene, James Pao, Erin Mulvey, Sophia X Zhou, Catherine M Albert, Fred Moy, Deepali Sachdev, Douglas Yee, Christoph Rader, Carl V Hamby, David M Loeb, Mitchell S Cairo, Xianzheng Zhou
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133152 (2015)
Patients with metastatic or recurrent and refractory sarcomas have a dismal prognosis. Therefore, new targeted therapies are urgently needed. This study was designed to evaluate chimeric antigen receptor (CAR) T cells targeting the type I insulin-lik
Externí odkaz:
https://doaj.org/article/4e8779c3a18148f587ae7ab7b4739633
Autor:
Vidhi Khanna, Jayanth Panyam, Arthur A. Decarlo, Deepali Sachdev, Da Yang, Stephen Kalscheuer, Sihan Li, Hyunjoon Kim
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
In recent years, there have been significant advances in the treatment of breast cancer resulting in remarkably high survival rates. However, treatment options for metastatic triple negative breast cancer (TNBC) are quite limited due to a lack of ide
Autor:
Irini Markella Antoniou, Emily J. Gallagher, Anupma Nayak, Zara Zelenko, Deepali Sachdev, Douglas Yee, Derek LeRoith
Publikováno v:
Endocrine-Related Cancer. 23:747-758
Type 2 diabetes (T2D) is associated with increased cancer risk and cancer-related mortality. Data herein show that we generated an immunodeficient hyperinsulinemic mouse by crossing theRag1−/−mice, which have no mature B or T lymphocytes, with th
Publikováno v:
Cancer Research. 80:P5-04
Hormone receptor positive (HR+) breast cancers that express estrogen receptor (ER) can recur 5-20 years after initial diagnosis and treatment, often as bone metastases. More than 30% of patients with early-stage HR+ breast cancer treated with endocri
Publikováno v:
Cancer Research. 75:P1-07
Insulin-like growth factors (IGFs) and insulin acting via the type I IGF receptor (IGF1R) and insulin receptor (IR) respectively regulate biology of estrogen positive (ER+) and triple negative (TN) breast cancer cells. In animal models, inhibition of
Autor:
Naoharu Kobayashi, Deepali Sachdev, Djaudat S. Idiyatullin, Curt Corum, Joseph Weber, Michael Garwood
Publikováno v:
Magnetic Resonance in Medicine. 73:1812-1819
Purpose To evaluate the capability of longitudinal MR scans using sweep imaging with Fourier transformation (SWIFT) to detect breast cancer metastasis to the lung in mice. Methods Mice with breast cancer metastatic to the lung were generated by tail
Publikováno v:
Cancer Research. 71:P5-13
Drugs targeting IGF1R are in clinical trials for breast cancer therapy. To date no suitable biomarkers of response have been identified for this therapy. It is important to select patients with tumors sensitive to disruption of IGF1R signaling. In ad
Autor:
Deepali Sachdev, Katelyn Hoff
Publikováno v:
Cancer Research. 78:2303-2303
Insulin-like growth factors (IGFs) and insulin signaling via the type I IGF receptor (IGF1R) and insulin receptor (IR) respectively, are potent activators of PI3K/Akt/mTOR. Drugs targeting IGF1R and the related IR were tested clinically including in
Publikováno v:
Cancer Research. 78:949-949
Luminal breast cancers account for ~75% of all cases and while adjuvant hormone therapy targeting ERα has significantly improved overall survival for patients with ER+ tumors, acquired resistance remains a major clinical problem. Tamoxifen-resistant