Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance

Autor: Jeremy A. Sullivan, Yusuke Tomita, Ewa Jankowska-Gan, Diego A. Lema, Matt P. Arvedson, Ashita Nair, William Bracamonte-Baran, Ying Zhou, Kristy K. Meyer, Weixiong Zhong, Deepali V. Sawant, Andrea L. Szymczak-Workman, Qianxia Zhang, Creg J. Workman, Seungpyo Hong, Dario A.A. Vignali, William J. Burlingham

Publikováno v: Cell Reports, Vol 30, Iss 4, Pp 1039-1051.e5 (2020)

Summary: Interleukin-35 (IL-35) is an immunosuppressive cytokine composed of Epstein-Barr-virus-induced protein 3 (Ebi3) and IL-12α chain (p35) subunits, yet the forms that IL-35 assume and its role in peripheral tolerance remain elusive. We induce

Externí odkaz: https://doaj.org/article/19bc2a5483074d60bb874b0ead25e86d

Dosing Regimens of Intravitreal Aflibercept for Diabetic Macular Edema Beyond the First Year: VIOLET, a Prospective Randomized Trial

Autor: Garweg, J.G., Jana, ?., Carel, H., Tobias, N., Thomas, S., Sergio, L., Sobha, S., Ursula, S., Andreas, W., Fareed, A., David, C., John, D., Michel, G., Jesia, H., Jaroslava, D., Jan, H., Laurent, K., Eric, S., Claudia, D., Karl-Heinz, E., Nicolas, F., Frank, H., Frank, K., Dirk, S., Walter, S., Agnes, K., Andras, P., Andras, S., Attila, V., Balazs, V., Francesco, B., Chiara, E., Edoardo, M., Massimo, N., Enrico, P., Federico, R., Viola, F., Gianni, V., Vilma-Jurate, B., Andrius, C., Ewa, G., Andrzej, G., Jakub, K., Zofia, M., Dorota, R., Marek, R., Bozena, R., Slawomir, T., Tomasz, Z., Miguel, A., Jo??o Castro Sousa, Manuel, F., Jo??o Pereira Figueira, Sara, V., Mikulas, A., Monika, G., Gabriela, P., Katarina, S., Alfredo, A., Lluis Arias Barquet, Anniken, B., Carlos Cava Valenciano, Enrique, C., Laura, S., Justus, G., Ioannis, P., Andrew, L., Martin, M., Deepali, V.

Publikováno v: Garweg, Justus G; Štefanickova, Jana; Hoyng, Carel; Niesen, Tobias; Schmelter, Thomas; Leal, Sergio; Sivaprasad, Sobha (2022). Dosing Regimens of Intravitreal Aflibercept for Diabetic Macular Edema Beyond the First Year: VIOLET, a Prospective Randomized Trial. Advances in therapy, 39(6), pp. 2701-2716. Springer 10.1007/s12325-022-02119-z

INTRODUCTION The purpose was to compare two flexible regimens of intravitreal aflibercept (IVT-AFL) with fixed dosing every 8 weeks, beyond the first year of treatment, in patients with diabetic macular edema (DME). VIOLET was a 100-week, randomized,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbec03ce9fc285fb4715f58e7bf95e6
https://doi.org/10.1007/s12325-022-02119-z

Algorithms and Classification through Machine Learning Methods

Autor: Shrinivas Deshpande, Deepali V. Pande

Publikováno v: Journal of Computer Science Engineering and Software Testing. 6:30-33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02ed9feb469132cb167082fdf9d9ed33
https://doi.org/10.46610/jocses.2020.v06i02.005

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

Autor: Chang Liu, Robert Lafyatis, Qianxia Zhang, David B. Corry, Mengting Liao, Tracy Tabib, Derrick J Callahan, Tao Sun, Wei Chen, Arjun Pennathur, Dario A. A. Vignali, Hiroshi Yano, Zhe Sun, Maria Chikina, Creg J. Workman, James D. Luketich, Tullia C. Bruno, Amanda C. Poholek, Deepali V. Sawant

Publikováno v: Nature Immunology. 20:724-735

Regulatory T cells (Treg cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. Treg cells subvert beneficial anti-tumor immunity by modulating inhibitory receptor expression on tumor-infiltrating lymphocytes (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da7198bb699d845bafaf82266a0c58b3
https://doi.org/10.1038/s41590-019-0346-9

STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets

Autor: Zhiyu Huang, Antony Symons, Laura Sekirov, Boxi Kang, Dan Wolak, Nathan Pierce, Wenjun Ouyang, Jason DeVoss, Deepali V. Sawant, Xian Liu, Zemin Zhang, Kristy Perez, Liangtao Zheng, Julie Y. Huang, Paolo Manzanillo, Dev Bhatt

Publikováno v: The Journal of Experimental Medicine

Single cell RNAseq analyses were performed on T cells from MC38 and CT26 tumor models. PCA-based sub-clustering and STARTRAC analyses revealed fine-tuned T cell subsets and dynamic in tumor. CCR8 was identified as a novel target on Tregs to synergize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430731e8ed0ed8f2fda88039ced175c8
https://doi.org/10.1084/jem.20201329