Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Deepak Shukla"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3692-3701 (2024)
Herpes Simplex Virus 1 (HSV-1) is a member of the alpha-Herpesviridae family, with over 60 % of the global population being seropositive. HSV-1 can cause a range of symptoms, from mild discomfort to severe, life-threatening complications. The emergen
Externí odkaz:
https://doaj.org/article/800e036dc4bc49ac89714ef8064dec1b
Autor:
Xiao-Tang Yin, Alexis Hartman, Nadia Sirajuddin, Deepak Shukla, Anthony St. Leger, Tammie L. Keadle, Patrick M. Stuart
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Reactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosp
Externí odkaz:
https://doaj.org/article/f1ec81674d424adba6b32ee87a214526
Autor:
Deepak Shukla
Publikováno v:
National Journal of Medical Research, Vol 14, Iss 02 (2024)
Externí odkaz:
https://doaj.org/article/3b08f13a77434d1b9397597aa4cf1ebd
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTTank-binding kinase 1 (TBK1) plays a pivotal role as a cellular factor in regulating the immune response against herpes simplex virus type 1 (HSV-1). TBK1’s role in defending against HSV-1 is attributed to its capacity to induce the type I
Externí odkaz:
https://doaj.org/article/a9a62baf4084410c9ef74c7a11451771
Autor:
James Elste, Nicole Cast, Shalini Udawatte, Kabita Adhikari, Shannon Harger Payen, Subhash C. Verma, Deepak Shukla, Michelle Swanson-Mungerson, Vaibhav Tiwari
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 821 (2024)
The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into human embryonic kidney (HEK293T) cells has been shown to be a cholesterol-rich, lipid raft-dependent process. In this study, we investigated if the presence of a cholester
Externí odkaz:
https://doaj.org/article/61b310de6e7f40a98b7a0fdeb26dca2f
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115056- (2023)
Herpes simplex viruses type-1 (HSV-1) and type-2 (HSV-2) are ubiquitous human pathogens causing serious pathologies in the ocular, orofacial and anogenital regions. While current treatments such as nucleoside analogs are effective in most cases, the
Externí odkaz:
https://doaj.org/article/419b5188165d4b979cfa61f124878aca
Autor:
James Elste, Angelica Chan, Chandrashekhar Patil, Vinisha Tripathi, Daniel M. Shadrack, Dinesh Jaishankar, Andrew Hawkey, Michelle Swanson Mungerson, Deepak Shukla, Vaibhav Tiwari
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1030-1040 (2023)
The structural diversity of metazoic heparan sulfate (HS) composed of unique sulfated domains is remarkably preserved among various vertebrates and invertebrate species. Interestingly the sulfated moieties of HS have been known as the key determinant
Externí odkaz:
https://doaj.org/article/56528fbe8e3f401f97c53e9003dfd746
Autor:
Tarun Bhatnagar, Sirshendu Chaudhuri, Manickam Ponnaiah, Pragya D Yadav, R Sabarinathan, Rima R Sahay, Faheem Ahmed, S Aswathy, Pankaj Bhardwaj, Anil Bilimale, M Santhosh Kumar, M. Logaraj, Uday Narlawar, C Palanivel, Prakash Patel, Sanjay K Rai, Vartika Saxena, Arvind Singh, Jeromie WV Thangaraj, Ashwini Agarwal, Yasir Alvi, Amoghashree, P Ashok, Dinesh Babu, Yogesh Bahurupi, Sangita Bhalavi, Priyamadhaba Behera, Priyanka Pandit Biswas, Jaykaran Charan, Nishant Kumar Chauhan, KB Chetak, Lalit Dar, Ayan Das, R Deepashree, Minakshi Dhar, Rahul Dhodapkar, TS Dipu, Mridu Dudeja, Manisha Dudhmal, Ravisekhar Gadepalli, Mahendra Kumar Garg, AV Gayathri, Akhil Dhanesh Goel, H Basavana Gowdappa, Randeep Guleria, Manoj Kumar Gupta, Farzana Islam, Mannu Jain, Vineet Jain, M Lanord Stanley Jawahar, Rajendra Joshi, Shashi Kant, Sitanshu Sekhar Kar, Deepjyoti Kalita, Meenakshi Khapre, Satyendra Khichar, Sarika Prabhakar Kombade, Sunil Kohli, Abhinendra Kumar, Anil Kumar, Deepak Kumar, Kiran G Kulirankal, KV Leela, Triparna Majumdar, Baijayantimala Mishra, Puneet Misra, Sanjeev Misra, Prasanta Raghab Mohapatra, M Narayana Murthy, Dimpal A Nyayanit, Manish Patel, Monika Pathania, Savita Patil, Binod Kumar Patro, Ramniwas Jalandra, Pragati Rathod, Naimesh Shah, Anita Shete, Deepak Shukla, M Shwethashree, Smita Sinha, MN Sumana, Ashish Surana, Anjan Trikha, A Tejashree, Mahalingam Venkateshan, G Vijaykrishnan, Sarita Wadhava, Naveet Wig, Nivedita Gupta, Priya Abraham, Manoj V Murhekar
Publikováno v:
International Journal of Infectious Diseases, Vol 122, Iss , Pp 693-702 (2022)
Objectives: India introduced BBV152/Covaxin and AZD1222/Covishield vaccines in January 2021. We estimated the effectiveness of these vaccines against severe COVID-19 among individuals aged ≥45 years. Methods: We did a multi-centric, hospital-based,
Externí odkaz:
https://doaj.org/article/ae9a4d01bbc948f5903a25216c64b295
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102342- (2023)
Summary: The study of inflammation is of key interest to biomedical research; however, techniques to induce inflammation in vitro are difficult to implement. Here, we present a protocol that optimizes the induction and measurement of NF-kB-mediated i
Externí odkaz:
https://doaj.org/article/2e114cbcf34a46789a34cd7a1e224ed8
Publikováno v:
National Journal of Medical Research, Vol 13, Iss 01 (2023)
Background: Dengue infections caused by the four antigenically distinct dengue virus serotypes (DENV1, DENV2, DENV3, DENV4) of the family Flaviviridae are the most major arboviral diseases in humans in terms of geographic spread, morbidity, and morta
Externí odkaz:
https://doaj.org/article/df1222e80aef49198025b8f9d4345726