Výsledky vyhledávání - "Deepak Reddy Gade"

Akademický článek

Novel indole derivatives as hepatitis C virus NS5B polymerase inhibitors: Pharmacophore modeling and 3D QSAR studies

Autor: G. Varun, M. Lokesh, M. Sandeep, Sajad Shahbazi, Deepak Reddy Gade

Publikováno v: Bangladesh Journal of Pharmacology, Vol 9, Iss 3 (2014)

Hepatitis C Virus (HCV) encodes its own RNA dependent RNA polymerase (NS5b) in order to replicate its genome. An efficient pharmacophore was identified, by executing structural analysis of a set of 49 indole-based inhibitors of the HCV NS5B polymeras

Externí odkaz: https://doaj.org/article/5707590ad4b943a5b4cef24541bcd8ae

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DESIGN SYNTHESIS OF NOVEL ACRIDINE TAGGED PYRAZOLE DERIVATIVES AS AURORA KINASE INHIBITORS

Autor: HARATHI PERKA, SATYAVATI D, DEEPAK REDDY GADE, VIVEKANANDA BOYA, RAJENDRA PRASAD VVS

Publikováno v: Asian Journal of Pharmaceutical and Clinical Research. :78-85

Objective: A series of novel synthesis of 5-Substituted-3-phenyl-4,5-dihydro-pyrazole-1-carbothioic acid [4-(9, 10-dihydro-acridin-9-yl)-phenyl]- amide (IV) were synthesized using standard procedures and evaluated for cytotoxic studies. Methods: 9-(4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f66b95dec6501c8f8c65f05cf08c5150
https://doi.org/10.22159/ajpcr.2020.v13i5.36997

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Novel 2,4-disubstituted quinazolines as cytotoxic agents and JAK2 inhibitors: Synthesis, in vitro evaluation and molecular dynamics studies

Autor: Harathi Perka, Rajendra Prasad Vvs, Mani Chandrika Paturi, Deepak Reddy Gade, Siva Jyothi Buggana

Publikováno v: Computational biology and chemistry. 79

Recent studies reported the involvement of JAK2/STAT3 pathway in various solid tumours including breast, ovarian, prostate and lung cancers. Clinical literature also reported the lowered burden in breast and ovarian cancers by targeting JAK2 pathway.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5e5a3c6231ece0155a3533d628ff00
https://pubmed.ncbi.nlm.nih.gov/30785020

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Elucidation of chemosensitization effect of acridones in cancer cell lines: Combined pharmacophore modeling, 3D QSAR, and molecular dynamics studies

Autor: B. S. Sastry, Godefridus J. Peters, Deepak Reddy Gade, V.V.S. Rajendra Prasad, Rajesh Babu Yarlagadda, Amareswararao Makkapati

Publikováno v: Computational Biology and Chemistry, 74, 63-75. Elsevier Ltd
Gade, D R, Makkapati, A, Yarlagadda, R B, Peters, G J, Sastry, B S & Rajendra Prasad, V V S 2018, ' Elucidation of chemosensitization effect of acridones in cancer cell lines: Combined pharmacophore modeling, 3D QSAR, and molecular dynamics studies ', Computational Biology and Chemistry, vol. 74, pp. 63-75 . https://doi.org/10.1016/j.compbiolchem.2018.02.014

Overexpression of P-glycoprotein (P-gp) leads to the emergence of multidrug resistance (MDR) in cancer treatment. Acridones have the potential to reverse MDR and sensitize cells. In the present study, we aimed to elucidate the chemosensitization pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998af819ff45ce6ce91ac89f0ce99d53
https://research.vumc.nl/en/publications/70621673-e62e-4c7e-92d4-1f99ee453b57

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Gedunin abrogates aldose reductase, PI3K/Akt/mToR, and NF-κB signaling pathways to inhibit angiogenesis in a hamster model of oral carcinogenesis

Autor: Geereddy Bhanuprakash Reddy, Siddavaram Nagini, Kranthi Kiran Kishore T., Deepak Reddy Gade, Raghu Ganugula

Publikováno v: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(2)

Aberrant activation of oncogenic signaling pathways plays a central role in tumor development and progression. The aim of this present study was to investigate the chemopreventive effects of the neem limonoid gedunin in the hamster model of oral canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f1f8d1013455e2b1ec6a88afcf0626
https://pubmed.ncbi.nlm.nih.gov/26342697

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Molecular insights of benzodipyrazole as CDK2 inhibitors: combined molecular docking, molecular dynamics, and 3D QSAR studies

Autor: Varun Guttikonda, Sasi Kala Maadwar, Divya Raavi, Deepak Reddy Gade

Benzodipyrazoles have been previously evaluated for their in vitro CDK2 inhibitory activity. In the current investigation, we identified a six-feature common pharmacophore model (AADDRR.33) which is predicted to be responsible for CDK2 inhibition. An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1064bd49fbb150b02783cb98f9f27d98

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Structural insights of JAK2 inhibitors: pharmacophore modeling and ligand-based 3D-QSAR studies of pyrido-indole derivatives

Autor: Pavan Kunala, Divya Raavi, Pavan Kumar K Reddy, Deepak Reddy Gade, Rajendra V V S Prasad

Publikováno v: Journal of receptor and signal transduction research. 35(2)

In this study we have performed pharmacophore modeling and built a 3D QSAR model for pyrido-indole derivatives as Janus Kinase 2 inhibitors. An efficient pharmacophore has been identified from a data set of 51 molecules and the identified pharmacopho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca99beb4b49c537390f4f68b1955079b
https://pubmed.ncbi.nlm.nih.gov/25140764

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Novel indole derivatives as hepatitis C virus NS5B polymerase inhibitors: Pharmacophore modeling and 3D QSAR studies

Autor: M. Sandeep, M. Lokesh, Deepak Reddy Gade, G. Varun, Sajad Shahbazi

Publikováno v: Bangladesh Journal of Pharmacology, Vol 9, Iss 3 (2014)
Bangladesh Journal of Pharmacology, Vol 9, Iss 3, Pp 290-297 (2014)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e480e5269d9de179e64f5bdeaada14b3
https://www.banglajol.info/index.php/BJP/article/view/18894

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