Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Deepak Raina"'
Autor:
Deepak Raina, Praveen Agarwal, James Lee, Ajit Bharti, C James McKnight, Pankaj Sharma, Surender Kharbanda, Donald Kufe
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135156 (2015)
Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly expressed in diverse human carcinomas and certain hematologic malignancies. The oncogenic MUC1 transmembrane C-terminal subunit (MUC1-C) functions in part by transducing growth and survival
Externí odkaz:
https://doaj.org/article/58ce5746a4b044f088d440954949e217
Publikováno v:
2023 International Symposium on Medical Robotics (ISMR).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5261e91aeb9b6e566ca33e2ca372e1c3
https://doi.org/10.1109/ismr57123.2023.10130193
https://doi.org/10.1109/ismr57123.2023.10130193
PDF file - 338K, 293T cells were left untreated or treated with G0-203 each day for 4 days. The results (mean plus-minus SD of three replicates) are expressed as the percentage of cell death as determined by trypan blue staining on day 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98853ee9ef8cbecb3ccb66cf376949cc
https://doi.org/10.1158/1541-7786.22509643.v1
https://doi.org/10.1158/1541-7786.22509643.v1
PDF file - 622K, BT474/MUC1shRNA (A) and MCF-7/vector (B) cells were treated with fixed IC50 ratios of (i) GO-203 alone on days 0, 1, 2, 3 and 4, (ii) tamoxifen alone on days 0, 2 and 4 and (iii) the GO-203/tamoxifen combination. For tamoxifen-resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd462c93316129fccd21966da6b676d
https://doi.org/10.1158/1541-7786.22509640
https://doi.org/10.1158/1541-7786.22509640
Supplementary Figure 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Autor:
Donald Kufe, Surender Kharbanda, Jeffrey Supko, Geoffrey I. Shapiro, Takeshi Shimamura, Maroof Alam, Hasan Rajabi, Govind Panchamoorthy, Rehan Ahmad, Michio Kosugi, Deepak Raina
Supplementary Figure 1 from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daf826a44199434d021ef42dac3a1e9
https://doi.org/10.1158/1535-7163.22497087
https://doi.org/10.1158/1535-7163.22497087
PDF file - 542K, A. MCF-7/MUC1-C cells were treated with 10 μM LY294002 (LY) for the indicated times. Lysates were immunoblotted with the indicated antibodies. B. MCF-7/MUC1-C cells were left untreated (Control) or treated with 10 μM LY294002 for 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa49d09c5dbb3364a18e3bf043530c29
https://doi.org/10.1158/1541-7786.22509649
https://doi.org/10.1158/1541-7786.22509649
Autor:
Donald Kufe, Surender Kharbanda, Jeffrey Supko, Geoffrey I. Shapiro, Takeshi Shimamura, Maroof Alam, Hasan Rajabi, Govind Panchamoorthy, Rehan Ahmad, Michio Kosugi, Deepak Raina
Non–small cell lung cancer (NSCLC) cells are often associated with constitutive activation of the phosphoinositide 3-kinase (PI3K) → Akt → mTOR pathway. The mucin 1 (MUC1) heterodimeric glycoprotein is aberrantly overexpressed in NSCLC cells an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::284828317a01282e68084203f80d7085
https://doi.org/10.1158/1535-7163.c.6535491
https://doi.org/10.1158/1535-7163.c.6535491
Autor:
Donald Kufe, Surender Kharbanda, Jeffrey Supko, Geoffrey I. Shapiro, Takeshi Shimamura, Maroof Alam, Hasan Rajabi, Govind Panchamoorthy, Rehan Ahmad, Michio Kosugi, Deepak Raina
Supplementary Figure S2ABCDE from Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca588fa498043bf5a5378dce13b454d
https://doi.org/10.1158/1535-7163.22497084.v1
https://doi.org/10.1158/1535-7163.22497084.v1
Tamoxifen resistance of estrogen receptor-positive (ER+) breast cancer cells has been linked in part to activation of receptor tyrosine kinases, such as HER2, and the PI3K-AKT pathway. Mucin 1 (MUC1) is aberrantly overexpressed in about 90% of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88222ef97087dc65f77e7cadfb8fe67c
https://doi.org/10.1158/1541-7786.c.6539356.v1
https://doi.org/10.1158/1541-7786.c.6539356.v1