Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Deepak P Srivastava"'
Neurodevelopmental disorder-associated ZBTB20 gene variants affect dendritic and synaptic structure.
Autor:
Kelly A Jones, Yue Luo, Lynn Dukes-Rimsky, Deepak P Srivastava, Richa Koul-Tewari, Theron A Russell, Lauren P Shapiro, Anand K Srivastava, Peter Penzes
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0203760 (2018)
Dendritic spine morphology and dendritic arborization are key determinants of neuronal connectivity and play critical roles in learning, memory and behavior function. Recently, defects of ZBTB20, a BTB and zinc finger domain containing transcriptiona
Externí odkaz:
https://doaj.org/article/345943e77a21481a809ad06d8ea1f0b6
Autor:
Adam Pavlinek, Dwaipayan Adhya, Alex Tsompanidis, Varun Warrier, Anthony C. Vernon, Madeline Lancaster, Jonathan Mill, Deepak P. Srivastava, Simon Baron-Cohen, Carrie Allison, Rosie Holt, Paula Smith, Tracey Parsons, Joanna Davis, Matthew Hassall, Daniel H. Geschwind, Alexander EP. Heazell, Alice Franklin, Rosie Bamford, Jonathan Davies, Matthew E. Hurles, Hilary C. Martin, Mahmoud Mousa, David H. Rowitch, Kathy K. Niakan, Graham J. Burton, Fateneh Ghafari, Lucia Dutan-Polit, Madeline A. Lancaster, Ilaria Chiaradia, Tal Biron-Shental, Lidia V. Gabis
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 5, Pp 100343- (2024)
Sex differences are widespread during neurodevelopment and play a role in neuropsychiatric conditions such as autism, which is more prevalent in males than females. In humans, males have been shown to have larger brain volumes than females with devel
Externí odkaz:
https://doaj.org/article/696dcf6345f647389e6fcc214263b982
Autor:
Rodrigo R. R. Duarte, Oliver Pain, Matthew L. Bendall, Miguel de Mulder Rougvie, Jez L. Marston, Sashika Selvackadunco, Claire Troakes, Szi Kay Leung, Rosemary A. Bamford, Jonathan Mill, Paul F. O’Reilly, Deepak P. Srivastava, Douglas F. Nixon, Timothy R. Powell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Human endogenous retroviruses (HERVs) are repetitive elements previously implicated in major psychiatric conditions, but their role in aetiology remains unclear. Here, we perform specialised transcriptome-wide association studies that consid
Externí odkaz:
https://doaj.org/article/b450345af2824456a3a8a93c234cbf75
Autor:
Deepak P Srivastava, Kevin M Woolfrey, Kelly A Jones, Charles T Anderson, Katharine R Smith, Theron A Russell, Hyerin Lee, Marina V Yasvoina, David L Wokosin, P Hande Ozdinler, Gordon M G Shepherd, Peter Penzes
Publikováno v:
PLoS Biology, Vol 10, Iss 6, p e1001350 (2012)
The architecture of dendritic arbors determines circuit connectivity, receptive fields, and computational properties of neurons, and dendritic structure is impaired in several psychiatric disorders. While apical and basal dendritic compartments of py
Externí odkaz:
https://doaj.org/article/82bebeeb8c44423d9a906dbfb32001e3
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Externí odkaz:
https://doaj.org/article/9c4a07a84fec41f383db581c73d8b2ee
Autor:
Ciara J. Molloy, Jennifer Cooke, Nicholas J. F. Gatford, Alejandro Rivera-Olvera, Sahar Avazzadeh, Judith R. Homberg, Joanes Grandjean, Cathy Fernandes, Sanbing Shen, Eva Loth, Deepak P. Srivastava, Louise Gallagher
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Multiple molecular pathways and cellular processes have been implicated in the neurobiology of autism and other neurodevelopmental conditions. There is a current focus on synaptic gene conditions, or synaptopathies, which refer to clinical conditions
Externí odkaz:
https://doaj.org/article/ab78ebda8b4e45e686f2ae9356555a2f
Cerebrospinal fluid markers for synaptic function and Alzheimer type changes in late life depression
Autor:
Nikias Siafarikas, Bjørn-Eivind Kirsebom, Deepak P. Srivastava, Cecilia M. Eriksson, Eirik Auning, Erik Hessen, Geir Selbaek, Kaj Blennow, Dag Aarsland, Tormod Fladby
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract To explore markers for synaptic function and Alzheimer disease (AD) pathology in late life depression (LLD), predementia AD and normal controls (NC). A cross-sectional study to compare cerebrospinal fluid (CSF) levels of neurogranin (Ng), Be
Externí odkaz:
https://doaj.org/article/ceac521b63374c52b81ca8b89a686a9d
Autor:
Leonard C. Steg, Gemma L. Shireby, Jennifer Imm, Jonathan P. Davies, Alice Franklin, Robert Flynn, Seema C. Namboori, Akshay Bhinge, Aaron R. Jeffries, Joe Burrage, Grant W. A. Neilson, Emma M. Walker, Leo W. Perfect, Jack Price, Grainne McAlonan, Deepak P. Srivastava, Nicholas J. Bray, Emma L. Cope, Kimberley M. Jones, Nicholas D. Allen, Ehsan Pishva, Emma L. Dempster, Katie Lunnon, Jonathan Mill, Eilis Hannon
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system. However, it is unknown how well they capture age-associated processes, par
Externí odkaz:
https://doaj.org/article/18efbbb134be4d4aa4a20747dc35b350
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/3ac1b75d69cd410eb3d5d881f1d7d849
Autor:
Dwaipayan Adhya, George Chennell, James A. Crowe, Eva P. Valencia-Alarcón, James Seyforth, Neveen A. Hosny, Marina V. Yasvoina, Robert Forster, Simon Baron-Cohen, Anthony C. Vernon, Deepak P. Srivastava
Publikováno v:
Molecular Autism, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract Background The inability to observe relevant biological processes in vivo significantly restricts human neurodevelopmental research. Advances in appropriate in vitro model systems, including patient-specific human brain organoids and human c
Externí odkaz:
https://doaj.org/article/e0a03a9f921846c5843ab324a3db80b9