Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Deepak P, Chandrasekharan"'
Autor:
Sam M. Janes, Nicholas McGranahan, Sergio A. Quezada, Yinyin Yuan, Teresa Marafioti, Peter J. Campbell, Christina Thirlwell, Charles Swanton, Jeremy George, Ricky M. Thakrar, Lisa M. Coussens, Courtney Betts, William Larson, Marie-Liesse Asselin-Labat, Claire Marceaux, Bernadette Carroll, Andrew J. Furness, Pascal F. Durrenberger, Sophia Antoniou, David A. Moore, Mary Falzon, Celine Denais, Yeman B. Hagos, Fraser R. Millar, Jake Y. Henry, Kate H.C. Gowers, Robert E. Hynds, Henry Lee-Six, Christodoulos P. Pipinikas, Deepak P. Chandrasekharan, Lukas Kalinke, Rachel Rosenthal, Ayse U. Akarca, Tom Lund, Shan E. Ahmed Raza, Khalid AbdulJabbar, Vitor H. Teixeira, Adam Pennycuick
Immune cell deconvolution from molecular data. Relative proportions of immune cell subtypes are predicted from gene expression data using the Danaher method, and from methylation data using methylCIBERSORT. Differences between progressive and regress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0408e249465611db42368906c8f88642
https://doi.org/10.1158/2159-8290.22536935.v1
https://doi.org/10.1158/2159-8290.22536935.v1
Autor:
Sam M. Janes, Nicholas McGranahan, Sergio A. Quezada, Yinyin Yuan, Teresa Marafioti, Peter J. Campbell, Christina Thirlwell, Charles Swanton, Jeremy George, Ricky M. Thakrar, Lisa M. Coussens, Courtney Betts, William Larson, Marie-Liesse Asselin-Labat, Claire Marceaux, Bernadette Carroll, Andrew J. Furness, Pascal F. Durrenberger, Sophia Antoniou, David A. Moore, Mary Falzon, Celine Denais, Yeman B. Hagos, Fraser R. Millar, Jake Y. Henry, Kate H.C. Gowers, Robert E. Hynds, Henry Lee-Six, Christodoulos P. Pipinikas, Deepak P. Chandrasekharan, Lukas Kalinke, Rachel Rosenthal, Ayse U. Akarca, Tom Lund, Shan E. Ahmed Raza, Khalid AbdulJabbar, Vitor H. Teixeira, Adam Pennycuick
Details of molecular investigations performed on each sample. Clinical and outcome data is also presented. In all cases with a previous history of lung cancer, this was of squamous histology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd5b38f07b3211f8bb49d7c3a31f120
https://doi.org/10.1158/2159-8290.22536941.v1
https://doi.org/10.1158/2159-8290.22536941.v1
Autor:
Sam M. Janes, Nicholas McGranahan, Sergio A. Quezada, Yinyin Yuan, Teresa Marafioti, Peter J. Campbell, Christina Thirlwell, Charles Swanton, Jeremy George, Ricky M. Thakrar, Lisa M. Coussens, Courtney Betts, William Larson, Marie-Liesse Asselin-Labat, Claire Marceaux, Bernadette Carroll, Andrew J. Furness, Pascal F. Durrenberger, Sophia Antoniou, David A. Moore, Mary Falzon, Celine Denais, Yeman B. Hagos, Fraser R. Millar, Jake Y. Henry, Kate H.C. Gowers, Robert E. Hynds, Henry Lee-Six, Christodoulos P. Pipinikas, Deepak P. Chandrasekharan, Lukas Kalinke, Rachel Rosenthal, Ayse U. Akarca, Tom Lund, Shan E. Ahmed Raza, Khalid AbdulJabbar, Vitor H. Teixeira, Adam Pennycuick
Markers used to define cell types in quantitative multiplex immunohistochemistry experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae658ff33e3c7953883b8a63fe19728
https://doi.org/10.1158/2159-8290.22536938
https://doi.org/10.1158/2159-8290.22536938
Autor:
Sam M. Janes, Nicholas McGranahan, Sergio A. Quezada, Yinyin Yuan, Teresa Marafioti, Peter J. Campbell, Christina Thirlwell, Charles Swanton, Jeremy George, Ricky M. Thakrar, Lisa M. Coussens, Courtney Betts, William Larson, Marie-Liesse Asselin-Labat, Claire Marceaux, Bernadette Carroll, Andrew J. Furness, Pascal F. Durrenberger, Sophia Antoniou, David A. Moore, Mary Falzon, Celine Denais, Yeman B. Hagos, Fraser R. Millar, Jake Y. Henry, Kate H.C. Gowers, Robert E. Hynds, Henry Lee-Six, Christodoulos P. Pipinikas, Deepak P. Chandrasekharan, Lukas Kalinke, Rachel Rosenthal, Ayse U. Akarca, Tom Lund, Shan E. Ahmed Raza, Khalid AbdulJabbar, Vitor H. Teixeira, Adam Pennycuick
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c889c181198e05bf5aa948da6e69f5d
https://doi.org/10.1158/2159-8290.22536944.v1
https://doi.org/10.1158/2159-8290.22536944.v1
Autor:
Sam M. Janes, Nicholas McGranahan, Sergio A. Quezada, Yinyin Yuan, Teresa Marafioti, Peter J. Campbell, Christina Thirlwell, Charles Swanton, Jeremy George, Ricky M. Thakrar, Lisa M. Coussens, Courtney Betts, William Larson, Marie-Liesse Asselin-Labat, Claire Marceaux, Bernadette Carroll, Andrew J. Furness, Pascal F. Durrenberger, Sophia Antoniou, David A. Moore, Mary Falzon, Celine Denais, Yeman B. Hagos, Fraser R. Millar, Jake Y. Henry, Kate H.C. Gowers, Robert E. Hynds, Henry Lee-Six, Christodoulos P. Pipinikas, Deepak P. Chandrasekharan, Lukas Kalinke, Rachel Rosenthal, Ayse U. Akarca, Tom Lund, Shan E. Ahmed Raza, Khalid AbdulJabbar, Vitor H. Teixeira, Adam Pennycuick
Gene lists used in this analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524194b93c86bc1d400a1f611f529b41
https://doi.org/10.1158/2159-8290.22536929.v1
https://doi.org/10.1158/2159-8290.22536929.v1
Autor:
Sam M. Janes, Nicholas McGranahan, Sergio A. Quezada, Yinyin Yuan, Teresa Marafioti, Peter J. Campbell, Christina Thirlwell, Charles Swanton, Jeremy George, Ricky M. Thakrar, Lisa M. Coussens, Courtney Betts, William Larson, Marie-Liesse Asselin-Labat, Claire Marceaux, Bernadette Carroll, Andrew J. Furness, Pascal F. Durrenberger, Sophia Antoniou, David A. Moore, Mary Falzon, Celine Denais, Yeman B. Hagos, Fraser R. Millar, Jake Y. Henry, Kate H.C. Gowers, Robert E. Hynds, Henry Lee-Six, Christodoulos P. Pipinikas, Deepak P. Chandrasekharan, Lukas Kalinke, Rachel Rosenthal, Ayse U. Akarca, Tom Lund, Shan E. Ahmed Raza, Khalid AbdulJabbar, Vitor H. Teixeira, Adam Pennycuick
Pathway analysis comparing the illumina and Affymetrix datasets as described in Supplementary Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b59cc88a888e97fb22401037f24d6e
https://doi.org/10.1158/2159-8290.22536926.v1
https://doi.org/10.1158/2159-8290.22536926.v1
Autor:
Sam M. Janes, Nicholas McGranahan, Sergio A. Quezada, Yinyin Yuan, Teresa Marafioti, Peter J. Campbell, Christina Thirlwell, Charles Swanton, Jeremy George, Ricky M. Thakrar, Lisa M. Coussens, Courtney Betts, William Larson, Marie-Liesse Asselin-Labat, Claire Marceaux, Bernadette Carroll, Andrew J. Furness, Pascal F. Durrenberger, Sophia Antoniou, David A. Moore, Mary Falzon, Celine Denais, Yeman B. Hagos, Fraser R. Millar, Jake Y. Henry, Kate H.C. Gowers, Robert E. Hynds, Henry Lee-Six, Christodoulos P. Pipinikas, Deepak P. Chandrasekharan, Lukas Kalinke, Rachel Rosenthal, Ayse U. Akarca, Tom Lund, Shan E. Ahmed Raza, Khalid AbdulJabbar, Vitor H. Teixeira, Adam Pennycuick
Before squamous cell lung cancer develops, precancerous lesions can be found in the airways. From longitudinal monitoring, we know that only half of such lesions become cancer, whereas a third spontaneously regress. Although recent studies have descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a98571a5212598e8738475feb59ae69d
https://doi.org/10.1158/2159-8290.c.6548276.v1
https://doi.org/10.1158/2159-8290.c.6548276.v1
Autor:
Peter J. Campbell, Adam Pennycuick, Inigo Martincorena, Kenichi Yoshida, Andrew Menzies, Tomonori Hirano, Ricky Thakrar, Sarah E. Clarke, Nobuyuki Kakiuchi, Colin R. Butler, Henry Lee-Six, Sam M. Janes, Kathryn Beal, Tim H. H. Coorens, Elizabeth Anderson, Michael R. Stratton, Kate H.C. Gowers, Elizabeth F. Maughan, Robert E. Hynds, Fraser R. Millar, Deepak P. Chandrasekharan
Publikováno v:
Nature. 578:266-272
Tobacco smoking causes lung cancer1–3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6–10, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbd71989032b18cec95132d877481f7c
https://doi.org/10.1038/s41586-020-1961-1
https://doi.org/10.1038/s41586-020-1961-1
Autor:
Christodoulos P. Pipinikas, Ricky Thakrar, Sergio A. Quezada, Vitor H. Teixeira, Sophia Antoniou, Adam Pennycuick, Jeremy George, Lukas Kalinke, Yinyin Yuan, Robert E. Hynds, Henry Lee-Six, Sam M. Janes, Fraser R. Millar, Celine Denais, Shan E Ahmed Raza, Andrew Furness, Jake Y. Henry, Nicholas McGranahan, Ayse Akarca, Christina Thirlwell, Claire Marceaux, Yeman Brhane Hagos, Lisa M. Coussens, Pascal F. Durrenberger, Marie Liesse Asselin-Labat, Peter J. Campbell, Charles Swanton, Khalid AbdulJabbar, Teresa Marafioti, Rachel Rosenthal, Deepak P. Chandrasekharan, Tom Lund, Kate H.C. Gowers, David A Moore, Mary Falzon, Bernadette Carroll, William Larson, Courtney Betts
Before squamous cell lung cancer develops, precancerous lesions can be found in the airways. From longitudinal monitoring, we know that only half of such lesions become cancer, whereas a third spontaneously regress. Although recent studies have descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c77375f391eea8fda27722adc7253b
http://wrap.warwick.ac.uk/139480/7/WRAP-Immune-surveillance-clinical-regression-pre-invasive-squamous-cell-lung-cancer-Raza-2020.pdf
http://wrap.warwick.ac.uk/139480/7/WRAP-Immune-surveillance-clinical-regression-pre-invasive-squamous-cell-lung-cancer-Raza-2020.pdf
Autor:
Inigo Martincorena, Michael R. Stratton, Tomonori Hirano, Deepak P. Chandrasekharan, Adam Pennycuick, Ricky Thakrar, Henry Lee-Six, Sam M. Janes, Nobuyuki Kakiuchi, Colin R. Butler, Sarah E. Clarke, Kate H.C. Gowers, Elizabeth F. Maughan, Elizabeth M. Anderson, Kathryn Beal, Andrew Menzies, Tim H. H. Coorens, Robert E. Hynds, Fraser R. Millar, Kenichi Yoshida, Peter J. Campbell
Publikováno v:
Nature
Summary Tobacco smoking causes lung cancer1–3, driven by the 60+ carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the lung cancer genome have been well documented6–10, but we lack equivalen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983919128feca0284a5e7e16ce961d26
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4090
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4090