Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Deepak Nijhawan"'
Autor:
Yilun Sun, Simone A. Baechler, Xiaohu Zhang, Suresh Kumar, Valentina M. Factor, Yasuhiro Arakawa, Cindy H. Chau, Kanako Okamoto, Anup Parikh, Bob Walker, Yijun P. Su, Jiji Chen, Tabitha Ting, Shar-yin N. Huang, Erin Beck, Zina Itkin, Crystal McKnight, Changqing Xie, Nitin Roper, Deepak Nijhawan, William Douglas Figg, Paul S. Meltzer, James C. Yang, Craig J. Thomas, Yves Pommier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergistically cytotoxic in human CRC cells.
Externí odkaz:
https://doaj.org/article/9bbad19d5fd14d8c895c04b8d779aa1f
Autor:
Yijie Wang, Yan Chen, Chenliang Wang, Mingming Yang, Yanan Wang, Lei Bao, Jennifer E. Wang, BongWoo Kim, Kara Y. Chan, Weizhi Xu, Emanuela Capota, Janice Ortega, Deepak Nijhawan, Guo-Min Li, Weibo Luo, Yingfei Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Replication stress is associated with cancer formation and progression. Here the authors reveal that the macrophage migration inhibitory factor (MIF) functions as 3’ flap nuclease involved in resolving replication stress affecting overall tumor pro
Externí odkaz:
https://doaj.org/article/e6e52889e32e4ede9a3a9d521e8846bc
Autor:
Tabitha C. Ting, Maria Goralski, Katherine Klein, Baiyun Wang, Jiwoong Kim, Yang Xie, Deepak Nijhawan
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1499-1510.e6 (2019)
Summary: Indisulam and related sulfonamides recruit the splicing factor RBM39 to the CRL4-DCAF15 E3 ubiquitin ligase, resulting in RBM39 ubiquitination and degradation. Here, we used a combination of domain mapping and random mutagenesis to identify
Externí odkaz:
https://doaj.org/article/2aa4a5719b314b839b7f24ae8b6afee9
Autor:
Joseph Rosenbluh, Deepak Nijhawan, Zhao Chen, Kwok-Kin Wong, Kenkichi Masutomi, William C Hahn
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26270 (2011)
RMRP is a non-coding RNA that is ubiquitously expressed in both humans and mice. RMRP mutations that lead to decreased RMRP levels are found in the pleiotropic syndrome Cartilage Hair Hypoplasia. To assess the effects of deleting RMRP, we engineered
Externí odkaz:
https://doaj.org/article/7358499a772045a6a22d1d510814526a
Autor:
Thu P. Nguyen, Wentian Wang, Alex C. Sternisha, Chase D. Corley, Hua-Yu Leo Wang, Xiaoyu Wang, Francisco Ortiz, Sang-Kyun Lim, Kalil G. Abdullah, Luis F. Parada, Noelle S. Williams, Samuel K. McBrayer, Jeffrey G. McDonald, Jef K. De Brabander, Deepak Nijhawan
Publikováno v:
Cell Chemical Biology. 30:214-229.e18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd96c829af682763a06a91520f41b37b
https://doi.org/10.1016/j.chembiol.2023.01.005
https://doi.org/10.1016/j.chembiol.2023.01.005
Autor:
Joseph M. Ready, Jose Francisco Calva-Moreno, Richard L. Boriack, Bin Hu, Deepak Nijhawan, Nikhil Madhusudhan, Khushbu Patel, Prashant Mishra
Publikováno v:
ACS Chemical Biology. 15:158-170
Selective toxicity among cancer cells of the same lineage is a hallmark of targeted therapies. As such, identifying compounds that impair proliferation to a subset of non-small lung cancer (NSCLC) cell lines represents one strategy to discover new dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bde9429e886e138bdbdff8c01d8da15
https://doi.org/10.1021/acschembio.9b00734
https://doi.org/10.1021/acschembio.9b00734
Autor:
Jin Zhou, Jeremy M. Simon, Chengheng Liao, Cheng Zhang, Lianxin Hu, Giada Zurlo, Xijuan Liu, Cheng Fan, Austin Hepperla, Liwei Jia, Vanina Toffessi Tcheuyap, Hua Zhong, Roy Elias, Jin Ye, W. Mike Henne, Payal Kapur, Deepak Nijhawan, James Brugarolas, Qing Zhang
Publikováno v:
Molecular cell. 82(16)
Characterized by intracellular lipid droplet accumulation, clear cell renal cell carcinoma (ccRCC) is resistant to cytotoxic chemotherapy and is a lethal disease. Through an unbiased siRNA screen of 2-oxoglutarate (2-OG)-dependent enzymes, which play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4056e6c6f707920d13eb00e5a0bee0de
https://pubmed.ncbi.nlm.nih.gov/35764091
https://pubmed.ncbi.nlm.nih.gov/35764091
Autor:
Yingfei Wang, Emanuela Capota, Bong Woo Kim, Weizhi Xu, Kara Y. Chan, Weibo Luo, Guo Min Li, Deepak Nijhawan, Yanan Wang, Yijie Wang, Lei Bao, Jennifer E. Wang, Mingming Yang, Janice Ortega, Chenliang Wang, Yan Chen
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
How cancer cells cope with high levels of replication stress during rapid proliferation is currently unclear. Here, we show that macrophage migration inhibitory factor (MIF) is a 3’ flap nuclease that translocates to the nucleus in S phase. Poly(AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b307c45fbf426edb48e82ccb8d7c36d5
http://europepmc.org/articles/PMC8134555
http://europepmc.org/articles/PMC8134555
Autor:
Shivendra V. Singh, Paul G. Thomas, Shibiao Wan, Peter J. Murray, Jie Fang, Ravi P. Singh, Melissa Johnson, Ahmed Abu-Zaid, Lee-Ann Van de Velde, Yiping Fan, Qiong Wu, Hongjian Jin, Jun J. Yang, Maria Goralski, Thomas Confer, David Craft, Ruoning Wang, Walter J. Akers, Waise Quarni, Andrew M. Davidoff, Tingting Wang, Deepak Nijhawan
Publikováno v:
Science Advances
Description
Degradation of RBM39 by indisulam leads to exceptional response in high-risk neuroblastoma.
Aberrant alternative pre-mRNA splicing plays a critical role in MYC-driven cancers and therefore may represent a therapeutic vulnerabili
Degradation of RBM39 by indisulam leads to exceptional response in high-risk neuroblastoma.
Aberrant alternative pre-mRNA splicing plays a critical role in MYC-driven cancers and therefore may represent a therapeutic vulnerabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb80e467b4392c9d3e6b6fc3f6f8f56
https://hdl.handle.net/21.11116/0000-0009-95A4-521.11116/0000-0009-95A6-321.11116/0000-0009-95A7-2
https://hdl.handle.net/21.11116/0000-0009-95A4-521.11116/0000-0009-95A6-321.11116/0000-0009-95A7-2
Autor:
Sophie Geboers, Hong Chen, Joseph M. Ready, Prema L. Mallipeddi, Bruce A. Posner, Giomar Rivera-Cancel, Francisco Ortiz, Stephen S. Gonzales, Panayotis C. Theodoropoulos, Deepak Nijhawan, Sukesh Voruganti, Noelle S. Williams, Jacinth Naidoo
Publikováno v:
Journal of medicinal chemistry. 63(17)
A series of N-acyl benzothiazoles shows selective and potent cytotoxicity against cancer cell lines expressing cytochrome P450 4F11. A prodrug form is metabolized by cancer cells into an active inhibitor of stearoyl-CoA desaturase (SCD). Substantial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458b3b8c04c31267e5649f3229fe5966
https://pubmed.ncbi.nlm.nih.gov/32787093
https://pubmed.ncbi.nlm.nih.gov/32787093