Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Deepak K Rajpal"'
Autor:
Johannes M Freudenberg, Zhi Liu, Jennifer Singh, Elizabeth Thomas, Christopher Traini, Deepak K Rajpal, Christopher J Sayed
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284047 (2023)
Hidradenitis suppurativa (HS) is a common, debilitating inflammatory skin disease linked to immune dysregulation and abnormalities in follicular structure and function. Several studies have characterized the transcriptomic profile of affected and una
Externí odkaz:
https://doaj.org/article/5b83f03bcfe14ae9b6f340bcb5246616
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background The Open Targets Platform integrates different data sources in order to facilitate identification of potential therapeutic drug targets to treat human diseases. It currently provides evidence for nearly 2.6 million potential targe
Externí odkaz:
https://doaj.org/article/7215bd07903a4fc9a32ae54218ef2001
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253614 (2021)
BackgroundThe identification of a target-indication pair is regarded as the first step in a traditional drug discovery and development process. Significant investment and attrition occur during discovery and development before a molecule is shown to
Externí odkaz:
https://doaj.org/article/d0c087013a1340469574ab1015671ef4
Autor:
William C Reisdorf, Qing Xie, Xin Zeng, Wensheng Xie, Neetu Rajpal, Bao Hoang, Mark E Burgert, Vinod Kumar, Mark R Hurle, Deepak K Rajpal, Sarah O'Donnell, Thomas T MacDonald, Anna Vossenkämper, Lin Wang, Mike Reilly, Bart J Votta, Yolanda Sanchez, Pankaj Agarwal
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215033 (2019)
Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH). EETs have pleiotropic effects, includin
Externí odkaz:
https://doaj.org/article/38fb9ef315534f3a84f10666efe0bd55
Autor:
Margaret G Ehm, Jennifer L Aponte, Mathias N Chiano, Laura M Yerges-Armstrong, Toby Johnson, Jonathan N Barker, Suzanne F Cook, Akanksha Gupta, David A Hinds, Li Li, Matthew R Nelson, Michael A Simpson, Chao Tian, Linda C McCarthy, Deepak K Rajpal, Dawn M Waterworth
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0186405 (2017)
A phenome-wide association study of variants in genes in the Th17 and IL-17 pathway was performed using self-reported phenotypes and genetic data from 521,000 research participants of 23andMe. Results replicated known associations with similar effect
Externí odkaz:
https://doaj.org/article/6497a762f65945019b80ef4fc6c25ce7
Autor:
Deepak K Rajpal, Jean-Louis Klein, David Mayhew, Joyce Boucheron, Aaron T Spivak, Vinod Kumar, Karen Ingraham, Mark Paulik, Lihong Chen, Stephanie Van Horn, Elizabeth Thomas, Ganesh Sathe, George P Livi, David J Holmes, James R Brown
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145499 (2015)
The gastrointestinal tract microbiome has been suggested as a potential therapeutic target for metabolic diseases such as obesity and Type 2 diabetes mellitus (T2DM). However, the relationship between changes in microbial communities and metabolic di
Externí odkaz:
https://doaj.org/article/91ca66012e4040b69d7532a6cd1d3711
Autor:
Shian-Huey Chiang, W Wallace Harrington, Guizhen Luo, Naphtali O Milliken, John C Ulrich, Jing Chen, Deepak K Rajpal, Ying Qian, Tiffany Carpenter, Rusty Murray, Robert S Geske, Stephen A Stimpson, Henning F Kramer, Curt D Haffner, J David Becherer, Frank Preugschat, Andrew N Billin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134927 (2015)
Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis. Intrac
Externí odkaz:
https://doaj.org/article/6c250288d3cf48f0b41fe25918c4ad63
Autor:
Pu Qin, Pelin Arabacilar, Roberta E. Bernard, Weike Bao, Alan R. Olzinski, Yuanjun Guo, Hind Lal, Stephen H. Eisennagel, Michael C. Platchek, Wensheng Xie, Julius del Rosario, Mohamad Nayal, Quinn Lu, Theresa Roethke, Christine G. Schnackenberg, Fe Wright, Michael P. Quaile, Wendy S. Halsey, Ashley M. Hughes, Ganesh M. Sathe, George P. Livi, Robert B. Kirkpatrick, Xiaoyan A. Qu, Deepak K. Rajpal, Maria Faelth Savitski, Marcus Bantscheff, Gerard Joberty, Giovanna Bergamini, Thomas L. Force, Gregory J. Gatto, Erding Hu, Robert N. Willette
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)
BackgroundThe amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects ge
Externí odkaz:
https://doaj.org/article/1c805dc589c7489c9f517443145877c9
Autor:
Samuel, Lessard, Chunla, He, Deepak K, Rajpal, Katherine, Klinger, Christine, Loh, Tim, Harris, Jennifer, Dumont
Publikováno v:
Frontiers in Medicine. 9
IntroductionUp to 30% of individuals with hemophilia A develop inhibitors to replacement factor VIII (FVIII), rendering the treatment ineffective. The underlying mechanism of inhibitor development remains poorly understood. The My Life, Our Future Re
Publikováno v:
BMC bioinformatics. 23(1)
Background The Open Targets (OT) Platform integrates a wide range of data sources on target-disease associations to facilitate identification of potential therapeutic drug targets to treat human diseases. However, due to the complexity that targets a